Lawson Research Institute

私营公司|Canada

更新于：2025-05-07

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NCT06156176

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Pursuing Reduction in Fatigue After COVID-19 Via Exercise and Rehabilitation (PREFACER): A Randomized Feasibility Trial

Long COVID is a complex condition that affects approximately 1.4 million Canadians following SARS-CoV-2 infection. Fatigue is the most common symptom of Long COVID. This feasibility trial will evaluate a new rehabilitation program called COVIDEx for treating fatigue after COVID-19, and compare its effectiveness to the standard treatment currently used. The experimental treatment group will receive an 8-week multi-modal rehabilitation program with two 50-minute sessions per week. 60 participants will be recruited, randomly assigned to the COVIDEx program or standard of care (SoC) and followed for 24 weeks.

开始日期2025-04-01

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Lawson Research Institute

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100 项与 Lawson Research Institute 相关的临床结果

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0 项与 Lawson Research Institute 相关的专利（医药）

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139

项与 Lawson Research Institute 相关的文献（医药）

2025-09-01·Mitochondrion

Mitochondrial transplantation: Triumphs, challenges, and impacts on nuclear genome remodelling

Review

作者: Castellani, Christina A ; Le, Quinn ; Shin, Elly H ; Barboza, Rachel ; Morin, Amanda ; Singh, Shiva M

Mitochondria are membrane-bound organelles of eukaryotic cells that play crucial roles in cell functioning and homeostasis, including ATP generation for cellular energy. Mitochondrial function is associated with several complex diseases and disorders, including cardiovascular, cardiometabolic, neurodegenerative diseases and some cancers. The risk for these diseases and disorders is often associated with mitochondrial dysfunction, particularly the quantitative and qualitative features of the mitochondrial genome. Emerging results implicate mito-nuclear crosstalk as the mechanism by which mtDNA variation affects complex disease outcomes. Experimental approaches are emerging for the targeting of mitochondria as a potential therapeutic for several of these diseases, particularly in the form of mitochondrial transplantation. Current approaches to mitochondrial transplantation generally involve isolating healthy mitochondria from donor cells and introducing them to diseased recipients towards amelioration of mitochondrial dysfunction. Using such a protocol, several reports have shown recovery of mitochondrial function and improved disease outcomes post-mitochondrial transplantation, highlighting its potential as a therapeutic method for several complex, severe and debilitating diseases. Additionally, the mitochondrial genome can be modified prior to transplantation to target disease-associated site-specific mutations and to reduce the ratio of mutant-to-WT alleles. These promising results may underlie the potential impact of mitochondrial transplantation on mito-nuclear genome interactions in the setting of the disease. Further, we recommend that mitochondrial transplantation experimentation include an assessment of potential impacts on remodelling of the nuclear genome, particularly the nuclear epigenome and transcriptome. Herein, we review these and other triumphs and challenges of mitochondrial transplantation as a potential novel therapeutic for mitochondria-associated diseases.

2025-07-01·Gait & Posture

Linking brain activation to standing balance performance: A systematic review and meta analysis of functional near-infrared spectroscopy literature

Review

作者: Pouliopoulou, Dimitra V ; Krougly, Nellie ; MacRae, Fraser ; Tsikrikis, Konstantinos ; Peters, Sue

BACKGROUNDFunctional Near-Infrared Spectroscopy (fNIRS) holds promise for clinical applications in the field of balance impairment amelioration; however, the relationship between fNIRS metrics and balance performance remains uncertain. We aimed to quantify the correlations between fNIRS-derived brain activation and standing balance performance, and determine variables that influence these associations.METHODSWe systematically reviewed English-language studies, published across PuBMed, PsycINFO, Embase, CINAHL, Ovid Medline, and Web of Science from inception up until July 1, 2024, that assessed standing balance tasks in adults > 18 years old with or without medical diagnosis measured with fNIRS. Pooled correlation coefficients were synthesized using a random effects restricted maximum likelihood model.RESULTSOverall, 17 studies were included with 420 participants. Key factors influencing the identified relationships were brain region and participant diagnosis. We identified moderate correlations between balance performance and cortical activation recorded by fNIRS in the supplementary motor area (SMA) (r = 0.52, 95 % CI = 0.39 0.64), and the prefrontal cortex (PFC) (r = 0.47, 95 % CI=0.32 - 0.60). In the PFC, increased oxygenated haemoglobin (HbO) was negatively associated with balance measures. The reverse relationship was reported in the PFC for individuals with physical and cognitive impairment. In the SMA, HbO was positively associated with balance. Few studies found associations between deoxygenated haemoglobin (HbR) and total hemoglobin (HbT) with balance performance.SIGNIFICANCECurrent evidence supports a relationship between fNIRS measures, specifically HbO, with standing balance performance. This relationship depends on the brain region measured, age, and the diagnosis of the participants. To better understand this relationship, there is a need to report standardized balance performance metrics alongside other metrics of interest to better synthesize data across publications. Improved understanding the neural basis of standing balance with fNIRS will lead to more informed interventions for balance rehabilitation.

2025-05-01·Healthcare Management Forum

From perpetual pilots to sustainable transformation: Scaling up geriatric care

Article

作者: Hiebert, Brad ; Omana, Humberto ; Elliott, Jacobi ; Heckman, George ; Chalmers, Karli ; Kane, Sheri-Lynn

With an ageing population, there is an increasing need to focus on the care of older adults, particularly those who are more medically complex. Frail older adults are more likely to require care from multiple providers across multiple settings. It is well recognized that the current Canadian healthcare system is not well-designed for this complex population. To address the health system challenges, health leaders are rapidly developing and implementing programs to better support the ageing population. Unfortunately, this often means that organizations are implementing and scaling health and social care programs with limited evidence or understanding of the specific context in which it was implemented. Drawing on regional experiences, this article will explore challenges and offer solutions related to the implementation, spread, and scale of healthcare programs for older adults.

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