At some point, all of the types of psychotropic medication have been used to treat PTSD. Evidence, however, supports the use of only two very different categories of medication in treating PTSD – SSRI/SNRI antidepressants (selegiline, paroxetine, and venlafaxine) and antihypertensives affecting the catecholamine system (prazosin and propranolol). Other agents having proven effectiveness in treating common comorbid diagnoses (e.g., insomnia and depression) are often useful in treating PTSD. But there is very little evidence indicating any effectiveness for many of the drugs and medications used historically, and are still being used, to treat patients with PTSD. Some of these agents have significant side effects (e.g., benzodiazepines can exacerbate the response to trauma, suppress natural capacities to cope with stress, and induce disinhibition). Many induce significant daytime sleepiness after use (e.g., antipsychotics, sedatives, sedating antidepressants, and anticonvulsants). Some such as the opiates and sedatives are toxic in overdose, especially when combined with ethanol. Others (e.g., cannabis and psychedelics) have received only minimal study due to their illegal status. In treating PTSD, the results obtained even in the most successful medication trials are far less impressive than those attained using non-drug psychological therapies as PE, IRT, and EMDR. The addition of one of these psychological therapies to the treatment regimens of PTSD patients treated only with medication is strongly recommended.