预约演示
更新于：2025-10-30
Siemens AG
更新于：2025-10-30
概览
关联
NCT07221058
Adaptive Radiation BOost for Rectal Cancer: a Phase I Dose Escalation Study (ARBOR)
NCT06995053
Image-Guidance With Triggered Beam Hold To Implanted Fiducial Markers or Hypersight for Stereotactic Body Radiotherapy for Prostate Cancer (ILLUSION)
NCT07175077
7T Brain MRI Scan for Micro-brain Metastasis (microBM) Detection for Patients With Small-cell Lung Cancer (SCLC), Who Decline Prophylactic Cranial Irradiation (PCI)
100 项与 Siemens AG 相关的临床结果
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2026-03-01Journal of Stomatology Oral and Maxillofacial Surgery
Comparative evaluation of photon-counting detector CT and cone-beam CT in the assessment of simulated mandibular trauma
Article
作者: Sandhu, Sameena ; Mergen, Victor ; Flohr, Thomas ; Burian, Egon ; Essig, Harald ; Kessler, Peter ; Alkadhi, Hatem ; Demmert, Tristan T ; Stadlinger, Bernd ; Al-Haj Husain, Adib ; Wagner, Maximilian Eberhard Hermann
INTRODUCTION:
This ex vivo study aimed to compare photon-counting detector computed tomography (PCD-CT) and cone-beam computed tomography (CBCT) at matched standard- and low-dose radiation levels for evaluating perioperative imaging parameters relevant to mandibular fracture stabilization with osteosynthesis plates.
MATERIAL AND METHODS:
Thirty-three osteosynthesis fixations were performed on six porcine mandibles with simulated fractures in the angle, body, and parasymphysis regions. Three types of plate systems (titanium microplates, titanium reconstruction plates, and bioresorbable copolymers) were used, each with varying plate thicknesses. Three blinded observers independently evaluated overall image quality, artifact severity, fracture line visibility, and visualization of peri‑osteosynthesis structures using 5-point visual analog scales. Descriptive statistics and inter-reader agreement (Krippendorff's alpha) were calculated.
RESULTS:
PCD-CT consistently demonstrated superior overall image quality, reduced artifact severity, and better visualization of fracture lines and peri‑osteosynthetic structures compared to CBCT, particularly using low-dose settings. Bioresorbable plates caused no artifacts in either modality. Inter-observer agreement was good to excellent across all parameters (Krippendorff's α = 0.72-1.0).
CONCLUSION:
PCD-CT outperformed CBCT in visualizing mandibular fracture stabilization with various osteosynthesis materials, particularly under low-dose conditions, demonstrating high reliability among observers. These findings indicate that PCD-CT may offer diagnostic advantages in the perioperative setting; however, further clinical studies are needed to confirm its role in imaging oral and maxillofacial trauma.
2026-01-01Clinical and Translational Radiation Oncology
First-in-human e-Flash radiotherapy using a modified conventional C-arm linear accelerator
Article
作者: Ramelyte, Egle ; Smith, Wendy ; Guckenberger, Matthias ; Psoroulas, Serena ; Mangana, Joanna ; von der Grün, Jens ; Vilalta, Marta ; Tanadini-Lang, Stephanie ; Dal Bello, Riccardo ; Tirpak, Lena ; Krayenbuehl, Jerome ; Fesslmeier, Debra ; Sharma, Ricky A ; Balermpas, Panagiotis
Background:
The FLASH effect is considered being the widening of the therapeutic window at (ultra-)high dose rates due to sparing of normal tissues while preserving tumor response. Our goal was to provide first data on the safety in treating a patient using a conventional linear accelerator converted to deliver 9 MeV UHDR electron beams in the research setting.
Material & methods:
A conventional Varian TrueBeam linac was converted in the research setting to become capable of delivering 9 MeV UHDR electron beams. A phase I trial protocol was approved by the local authorities (NCT06549439). One patient with ≥ 1 melanoma (sub)-cutaneous lesion(s) was treated with 3x 9 Gy. The first two fractions were applied via e-Flash and the third via conventional electrons.
Results:
Here we present the experience of the first patient treated with e-Flash in a modified conventional linac. The e-Flash fractions were successfully delivered according to the protocol. The film in-vivo dosimetry confirmed correctness of the delivered dose. A good tumor response without severe or unexpected toxicity was observed up to six weeks after treatment.
Conclusion:
We demonstrate first-in-human application of e-Flash delivered by a modified conventional linear accelerator. Conversion of conventional linacs into e-Flash systems will accelerate testing Flash radiotherapy in clinical trials.
2026-01-01CLINICA CHIMICA ACTA
Demonstrating commutability of an existing certified reference material for use with an end-user measurement procedure that was not included in the original commutability assessment
Article
作者: Panteghini, Mauro ; Miller, W Greg ; Fauskanger, Pernille Kjeilen ; Lyle, Alicia N ; Rej, Robert ; Deprez, Liesbet ; Budd, Jeffrey ; Weykamp, Cas ; Sandberg, Sverre ; Keller, Thomas ; Barczak, Elizabeth ; Delatour, Vincent ; Johansen, Jesper V ; MacKenzie, Finlay ; Greenberg, Neil ; Camara, Johanna E
Commutability assessment of a certified reference material (CRM) intended for use as a secondary calibrator should be performed by the CRM producer at the time the material is originally prepared. Assessment typically includes several in-vitro diagnostic (IVD) measurement procedures (MPs) in common use in medical laboratories. Due to logistical constraints, it is usually not possible to include all existing IVD-MPs in a commutability assessment. In addition, a new IVD-MP (IVD-MPn) may be introduced into the market after a commutability assessment was performed for a given CRM. Here we provide a recommendation how to assess commutability of an existing CRM for use with an IVD-MPn that was not included in the original commutability assessment. The study design follows the same principles as a full commutability assessment, but it includes only the IVD-MPn and fewer additional comparator MP(s) for which the CRM's commutability with clinical samples was previously demonstrated. When no reference measurement procedure (RMP) is available, or when the logistics make an RMP difficult to use, other IVD-MP(s) that were part of the original commutability assessment for the CRM should be used as comparator MP(s). When selecting a comparator IVD-MP, its performance must be carefully considered and its selectivity for the measurand should be equivalent to that of the IVD-MPn. The CRM should have had negligible noncommutability bias with the comparator IVD-MP in the original commutability assessment. When the existing CRM meets the commutability criterion for IVD-MPn, the CRM can be used in the calibration hierarchy of the IVD-MPn.
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