The investigators plan to conduct an R61/33 hybrid type 2 implementation-effectiveness trial that includes 1) a one-year exploratory R61 phase that will enable the development of the intervention protocol needed for the R33 trial phase including concrete R61 phase milestones; 2) a four-year R33 phase that will include a concurrent implementation evaluation and a randomized control trial.

开始日期2025-11-01

申办/合作机构

Duke University

[+4]

NCT06573476

/ Enrolling by invitationN/AIIT

Addressing Racial Disparities in Opioid Overdose Deaths Using an Open Source Peer Recovery Coach Training and Multimodal Mobile Health Platform

The study aims to adapt an existing Cultural Structural Humility (CSH) training into a video format for peer recovery coaches (PRCs) and refine an AI-driven texting tool to reinforce the training. After refining these tools using user-centered design, a pilot test will be conducted to assess their impact on the uptake of opioid treatment and social services. The study will also evaluate the feasibility and effectiveness of the intervention to inform future large-scale trials.

开始日期2025-03-20

申办/合作机构

Friends Research Institute, Inc.

[+2]

NCT06079840

/ RecruitingN/A

Mindfulness Based Stress Reduction App for African American Caregivers

African American caregivers of people living with HIV/AIDS (PLWHA) have unique needs because they are more likely to experience stressors related to intersecting sources of stigma, discrimination, and caregiving burdens specifically associated with caregiving for PLWHA. The proposed project will enhance and finalize Phase I app development and evaluate its effectiveness in a randomized controlled trial. The project has high public health significance because of its potential to provide an accessible, easy to use mindfulness-based support tool for African American caregivers that could reduce stress, mitigate the harm of intersecting stigmas, and strengthen the caregiver-care recipient relationship.

开始日期2025-03-18

申办/合作机构

Friends Research Institute, Inc.

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项与 Friends Research Institute, Inc. 相关的文献（医药）

2025-04-25·The Journal of Sexual Medicine

(184) ASSESSING SEXUAL FUNCTION AMONG WOMEN RECEIVING MEDICATION FOR OPIOID USE DISORDER IN AN OBSTETRICS AND GYNECOLOGY CLINIC: PRELIMINARY DATA

作者: Terplan, M ; Poland, C ; Stoltman, J ; Burr, E

AbstractIntroductionThere is a significant knowledge gap about sexual function in those assigned female at birth (AFAB) on medication for opioid use disorder (MOUD).ObjectiveThis study seeks to identify trends in sexual function among those AFAB receiving MOUD by utilizing the Female Sexual Function Index (FSFI) in an ambulatory obstetrics and gynecology setting.MethodsPatients at an ambulatory obstetrics and gynecology clinic filled out a survey assessing opioid use history, MOUD regimen, reproductive history, and the FSFI. Participants were eligible if they were older than 18 years, were assigned female at birth, and were currently receiving MOUD. The cutoff for identifying sexual dysfunction in participants was an FSFI score of 26.55.ResultsEight female participants receiving MOUD were approached for the study, and all eight completed the survey (100%) (Table 1). Four participants (50%) were sexually active in the past month. Of the sexually active participants, one was found to have sexual dysfunction and three were not (Table 2). The “desire” domain was the lowest average FSFI domain for sexually active participants (3.15 ± 0.78 out of 6 possible points). Of the four participants who were not sexually active in the past month, two stated lack of desire, one stated lack of desire and having given birth recently, and one stated both lack of desire and discomfort/pain during sexual activity as the reasons for absence of sexual activity in the past month. When asked if they had noticed a change in their sexual function after initiating MOUD, 75% (6/8) of participants reported noticing a severe, moderate, or mild decrease in sexual function overall and 87.5% (7/8) reported intense, moderate, or mild difficulty with arousal after initiating MOUD.ConclusionsLack of sexual desire appears to be a problem in this preliminary sample of women receiving MOUD. Half of the participants surveyed attributed the absence of recent sexual activity to difficulties with sexual desire, and in those who were sexually active, overall sexual function was mostly intact, but desire was still the lowest ranked domain. A larger sample size will allow for better understanding of the role that pregnancy, recent opioid use, and MOUD play in modulating desire as a crucial part of sexual function for those AFAB.DisclosureNo.

2025-04-01·American Journal of Obstetrics and Gynecology

Substance use and use disorders during pregnancy and the postpartum period

Review

作者: Habersham, Leah L ; Townsel, Courtney ; Terplan, Mishka ; Hurd, Yasmin L

Substance use and substance use disorders among pregnant and postpartum individuals have risen dramatically, necessitating enhanced clinician education and intervention strategies. This expert review offers obstetricians and gynecologists a comprehensive overview of substance use during the prenatal and postpartum periods. We discuss the epidemiology, maternal and fetal adverse effects, as well as treatment approaches for major substances: nicotine, cannabis, alcohol, benzodiazepines, stimulants, and opioids. Additionally, we address the ethical and legal implications of substance use during pregnancy and emphasize the importance of equitable and nonstigmatizing care. By integrating evidence-based practices, we aim to support obstetricians and gynecologists in providing optimal care for pregnant and postpartum individuals affected by substance use disorders.

2025-04-01·AIDS and Behavior

PrEP Disparities Among Transgender Feminine, Transgender Masculine, Nonbinary, and Gender Expansive Youth and Young Adults in the United States

Article

作者: Lakshmanan, Swetha ; Flynn, Risa P ; Reback, Cathy J ; Ward, Demi ; Comulada, W Scott ; Horvath, Keith J ; Fehrenbacher, Anne E ; Tapia, Yara ; Swendeman, Dallas T ; Cain, Demetria ; Sullivan, Patrick S ; Polanco, Dianna ; Rusow, Joshua A

AbstractThis study assessed disparities in pre-exposure prophylaxis (PrEP) use among transgender and gender expansive youth and young adults (N = 477) between 15 and 24 years old in the CARES (ATN 149) and TechStep (ATN 160) study protocols within the National Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN). Structural equation modeling was used to test mediation pathways between gender identity and PrEP uptake among the full sample and stratified by sex assigned at birth. Lifetime PrEP uptake was higher among those assigned male at birth (26%) versus assigned female at birth (9%), explained by greater structural and behavioral risks and perceived need for PrEP, especially among trans women. Among those assigned female at birth, PrEP uptake was higher among trans men (12%) than nonbinary participants (6%). Our findings characterize key structural and behavioral drivers of PrEP use and highlight the need to reduce barriers to healthcare for trans youth, particularly in the South.

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