The goal of this observational study is to define digital biomarkers of motor symptoms in Parkinson's disease patients using wearable devices. The main questions it aims to answer is:
* Is there a biomarkers that allows the identification of PD from healthy controls?
* Is there a biomarkers that can identify the severity of the disease?
* Is there a biomarkers with clinical and therapeutic application that can be used in clinical and free living conditions to monitor the evolution of the disease?
Participants have to perform a set of guided exercises related to the MDS-UPDRS guide and daily living tasks, in supervised and unsupervised conditions.

开始日期2024-12-09

申办/合作机构

Universidad Politécnica de Madrid

NCT06172712

/ RecruitingN/AIIT

COPD Exacerbation Modelling Study Using Daily-life Data From Unobtrusive Sensors - the TOLIFE Clinical Study A

This work is a multicentric prospective cohort study designed to improve chronic obstructive pulmonary disease (COPD) treatment and management. The study involves 150 patients diagnosed with COPD who are at risk of exacerbations. These patients are recruited from three tertiary hospitals in Spain, Germany, and Italy. The study will last 18 months, with a 12-month follow-up duration for each patient. The primary objective of this study is to develop and test Artificial Intelligence (AI)-based models that can predict moderate-to-severe COPD exacerbations early on. This will be done by analyzing daily-life data collected from unobtrusive sensors that monitor patients' psycho-physiological and environmental signals. By accurately predicting exacerbations, the study aims to support clinicians in providing more precise, optimized, and personalized treatment to COPD patients. A secondary objective is to train and test AI-based models to estimate the 12-month dynamics of health-related quality of life (HRQoL) in COPD patients. This will involve analyzing data related to the patients' functional exercise capacity, dyspnea (difficulty breathing), and health-related quality of life, as measured by the Clinical COPD Questionnaire (CCQ) score and the COPD Assessment Test (CAT) score.

开始日期2024-05-08

申办/合作机构

Barcelona Institute for Global Health

[+3]

NCT06322446

/ RecruitingN/A

Effects of a Strength Exercise Program on Muscular Health in People With CF Treated With Modulators of the Cystic Fibrosis Transmembrane Conductance Regulator Receptor (CFTR)

Recently, the treatment of Cystic Fibrosis (CF) incorporated new modulators/enhancers of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). It is thus increasingly important to study the side effects of these drugs, their extrapulmonary effects and possible interaction with other drugs and with exercise. For this purpose, a randomized controlled trial is proposed to determine the effects of a telematic exercise intervention on muscle health, in a group of 48 children and adolescents with CF treated with these new generation CFTR modulators. They will be randomly assigned to two groups (exercise and control group). The effect of the intervention will be analysed measuring the variables of muscle health, cardiorespiratory fitness, lung function, body composition, inflammatory biomarkers and miRNAs. After completion of the intervention program, adherence to exercise and clinical evolution after one year will be analysed.

开始日期2024-02-27

申办/合作机构

Universidad Politécnica de Madrid

[+4]

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项与 Universidad Politécnica de Madrid 相关的文献（医药）

2025-12-31·Virtual and Physical Prototyping

The microstructure and mechanical properties of nitinol manufactured by LPBF: differences between Ni-rich and Ti-rich compositions

作者: Zapata Martínez, Rodrigo ; Ordoño, Jesús ; Molina-Aldareguia, Jon ; Li, Muzi ; Contreras-Almengor, Oscar ; Aguilar Vega, Carlos ; Díaz-Lantada, Andrés ; Echeverry-Rendón, M.

2025-07-01·Separation and Purification Technology

Heat integration and process improvement of a batch distillation unit using a gradual feeding strategy: A case study on MIBK-water separation

作者: Niazi, Saber ; Diaz-Lopez, Jose Antonio ; Nieto-Marquez, Antonio

This work focuses on upgrading a batch distillation unit in terms of energy efficiency and production capacity.Dehydration of Me iso-Bu ketone (MIBK) is performed as a case study.Since the MIBK-water mixture forms a heteroazeotrope, a decanter is applied to facilitate the separation process.The unit performance is evaluated in terms of specific product flow (SPF) and specific energy cost (SEC).Studying the impact of feed quantity in the range of 20 to 80 kg showed that due to the almost equal holdup loss, a larger batch feed quantity results in higher energy efficiency and production performance.Gradual feeding policy with different feeding strategies and locations (i.e., top feeding and bottom feeding) is also assessed in detail and compared with the conventional batch distillation process.Also, three feeding rate profiles (increasing, fixed, and decreasing) with varying feeding durations are evaluated in order to reach the optimal feeding time and profile.Overall, gradual feeding is found to be an efficient approach to upgrade the unit operation in terms of energy efficiency and production rate.Top feeding (also known as batch stripping or inverted batch distillation) has proved to be a more efficient policy for MIBK-water separation over bottom feeding.In addition, the decreasing feed flow rate scenario offers a more efficient operation compared to other feed rate profiles.Accordingly, employing the top feeding policy with a decreasing feed rate profile can lead to a 10% improvement in production rate and energy cost over a conventional batch distillation unit equipped with a decanter.Moreover, based on the gradual feeding approach, a novel and easy-to-apply strategy for heat integration and recovery in the batch distillation process is proposed, and its potential is assessed for different feeding scenarios.The proposed strategy is also found to be significantly effective in process intensification and acceleration.Applying this strategy to a batch distillation unit with top feeding at a fixed feed rate offers over 47% improvement in energy efficiency and production rate compared to a conventional batch distillation unit equipped with a decanter.

2025-06-30·ACM Transactions on Quantum Computing

Forward and Backward Constrained Bisimulations for Quantum Circuits Using Decision Diagrams

作者: Burgholzer, Lukas ; Tschaikowski, Max ; Wille, Robert ; Jimenez-Pastor, Antonio ; Tribastone, Mirco ; Larsen, Kim Guldstrand

Efficient methods for the simulation of quantum circuits on classical computers are crucial for their analysis due to the exponential growth of the problem size with the number of qubits. Here we study lumping methods based on bisimulation, an established class of techniques that has been proven successful for (classic) stochastic and deterministic systems such as Markov chains and ordinary differential equations. Forward constrained bisimulation yields a lower-dimensional model which exactly preserves quantum measurements projected on a linear subspace of interest. Backward constrained bisimulation gives a reduction that is valid on a subspace containing the circuit input, from which the circuit result can be fully recovered. We provide an algorithm to compute the constraint bisimulations yielding coarsest reductions in both cases, using a duality result relating the two notions. As applications, we provide theoretical bounds on the size of the reduced state space for well-known quantum algorithms for search, optimization, and factorization. Using a prototype implementation, we report significant reductions on a set of benchmarks. In particular, we show that constrained bisimulation can boost decision-diagram-based quantum circuit simulation by several orders of magnitude, allowing thus for substantial synergy effects.

项与 Universidad Politécnica de Madrid 相关的新闻（医药）

2023-07-17

·drugs

Superagers Have Faster Movement Speed Than Typical Older Adults

MONDAY, July 17, 2023 -- Superagers exhibit higher grey matter volume cross-sectionally and show slower total grey matter atrophy longitudinally than typical older adults, according to a study published online July 13 in The Lancet Healthy Longevity . Marta Garo-Pascual, from Universidad Politécnica de Madrid, and colleagues characterized the brain structure of superagers and identified demographic, lifestyle, and clinical factors associated with this phenotype in a study involving 64 superagers and 55 typical older adults. Superagers were classified based on scoring at or above the mean values for a 50- to 56-year-old in the Free and Cued Selective Reminding Test and within one standard deviation of the mean or greater for their age and education level in the three nonmemory tests. The researchers found that cross-sectionally, superagers exhibited higher grey matter in the medial temporal lobe, cholinergic forebrain, and motor thalamus. Compared with typical older adults, they also showed slower total grey matter atrophy longitudinally, especially within the median temporal lobe. Faster moving speed and better mental health were the most differentiating factors for superagers in a machine learning classification that included 89 demographic, lifestyle, and clinical predictors. Group differences reflected inherent superager resistance to typical age-related memory loss based on similar concentrations of dementia blood biomarkers in superager and typical older adult groups. "The observed between-group differences are therefore likely to reflect a superager resistance to age-related memory decline, rather than two groups at different points of a dementia-related process," the authors write. Abstract/Full Text Editorial Posted July 2023

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100 项与 Universidad Politécnica de Madrid 相关的转化医学

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