Effectiveness of Connective Tissue Graft With and Without Leukocyte Platelet Rich Fibrin on Peri-implant Soft Tissue Thickness Around Delayed Implants in Patients With Thin Gingival Phenotype: A Randomized Controlled Clinical Trial

A stable soft and hard tissues around Osseo-integrated implants are very crucial. Soft tissue thickness around implants is crucial as it prevents peri-implant bone loss and enhance the esthetic outcomes. The treatment of thin tissue phenotype should be improved as the thin tissue phenotype will lead to plaque accumulation. There are some techniques that can increase the thickness of the peri-implant mucosa including connective tissue graft, platelet- rich fibrin and xenogeneic collagen matrix .Leukocyte and Platelet rich fibrin is a second generation platelet concentrate that was introduced by choukroun et al in 2001 after platelet rich plasma. PRF is the first source of autogenous blood derived growth factors harvested without the use of anticoagulants5. It contains various growth factors that are believed to contribute to periodontal regeneration. It promotes neovascularization and accelerated wound closing

开始日期2026-01-16

申办/合作机构

British University of Egypt

NCT06207253

/ Recruiting临床2/3期IIT

The Antimicrobial Potential of Diclofenac Sodium as an Intracanal Medicament During Root Canal Treatment: A Randomized Clinical Trial

The goal of this randomized clinical trial is to evaluate the capability of the material to exert bacterial reduction of diclofenac sodium versus of that calcium hydroxide paste when these materials are used as intracanal medications in permanent molar teeth with chronic apical periodontitis.
The main question[s] it aims to answer are:
• Will the diclofenac sodium (NSAIDs) possess antimicrobial efficacy to be used effectively as an intracanal medicament similar to that of calcium hydroxide in primary endodontic treatment? Participants will be allocated randomly into three equal groups by using computer generated randomization, according to the type of intracanal medication.

开始日期2025-11-01

申办/合作机构

British University of Egypt

NCT07115758

/ Not yet recruitingN/AIIT

The Impact of Vestibular Versus Trapezoidal Flap Design on Immediate Implants : a Randomized Clinical Trial

The vestibular socket therapy was introduced by Elaskary et al that allowed immediate implant placement and total socket rehabilitation at the same time in class 2 compromised sockets , that showed supreme esthetic and functional predictability over 1,2,3 years of follow up, and showed minimal or no post restorative mid facial recession . The Vestibular socket therapy (VST) entails socket augmentation through a minimally invasive vestibular access incision to allow the delivery of the grafting components thus bypass the deleterious effect of the classic mucoperiosteal flap reflection as well as the deleterious effect of the delay approach, regardless of the degree of socket compromise [6-8].

开始日期2025-08-15

申办/合作机构

British University of Egypt

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项与 British University of Egypt 相关的文献（医药）

2026-01-23·MEDICINE

Juvenile rhupus syndrome: A case report of coexistence of JIA and SLE

Article

作者: Ur Rehman, Wajeeh ; Ullah, Naeem ; Kamil, Kamil Ahmad ; Ullah, Zia ; Kashif Habib, Muhammad ; Elalfy, Amal ; Abedeen, Zain Ul

Background::

Juvenile rhupus syndrome is the coexistence of juvenile idiopathic arthritis (JIA) and systemic lupus erythematosus (SLE) in a pediatric patient. It is a rare but clinically significant autoimmune overlap syndrome.

Case::

We present a case of a 10-year-old girl (initially diagnosed with rheumatoid factor-positive polyarticular JIA and being treated with methotrexate) who developed features suggestive of an SLE flare-up and/or methotrexate toxicity, including pallor, non-scarring alopecia, dyspnea, pancytopenia, impaired liver function tests, and restricted mobility in the elbow and knee joints; however, laboratory reports indicated elevated antinuclear antibody and anti-double-stranded DNA antibodies titers, as well as decreased complement levels. After thorough clinical assessment and excluding other potential causes, she fulfilled the 2019 European League Against Rheumatism /American College of Rheumatology criteria for SLE diagnosis, leading to the diagnosis of juvenile rhupus syndrome. Such disease evolution required therapeutic reassessment, and her immunosuppressive regimen was revised.

Conclusion::

Rhupus syndrome is just as significant in children as it is in adults, where it is more commonly reported. Early recognition and adequate therapy are essential for improved clinical outcomes as juvenile rhupus often shows severe systemic involvement and increased morbidity compared to isolated JIA or SLE. Our case contributes to the limited literature on juvenile rhupus and highlights the need for clear diagnostic criteria and management guidelines.

2026-01-01·JOURNAL OF CRANIOFACIAL SURGERY

Digitally Fabricated Interocclusal Wafer Versus Wafer-Less Distal Segment Repositioning for Bilateral Sagittal Split Osteotomy (BSSO) in Skeletal Mandibular Deformities (Randomized Controlled Trial)

Article

作者: Omara, Mohammed ; El-Behairy, Galal ; Morsi, Hesham O. ; Shendy, Mostafa I.

Objective::

This study aimed to compare the accuracy of condylar positioning between 2 computer-guided orthognathic surgical protocols: a waferless screw hole plate locating (WSL-CPD) technique versus an occlusal splint with distal extending arms (OWDA-CPD) approach.

Materials and Methods::

Twenty-four patients requiring mandibular orthognathic surgery (class II or III deformities) were randomly allocated into 2 groups (n=12 each). Group I underwent a waferless protocol utilizing 3D-printed osteotomy and screw hole locating guides, while group II received an occlusal splint with distal extensions for condylar positioning. Preoperative and postoperative cone-beam computed tomography (CBCT) scans were used to assess condylar displacement in linear (anteroposterior, mediolateral, vertical) and angular (rotational) dimensions. Statistical analysis was performed using the Mann-Whitney U test.

Results::

No statistically significant differences were observed between the 2 groups in linear or angular condylar deviations. Median linear deviations in the WSL-CPD group were 0.45 mm (mediolateral), 0.3 mm (anteroposterior), and 0.35 mm (vertical), while the OWDA-CPD group showed 0.35 mm, and 0.2 mm, respectively (all P values>0.05). Angular deviations were also comparable, with median rotational changes below 1 degree in both groups.

Conclusion::

Both waferless and occlusal splint-based condylar positioning techniques demonstrated similar accuracy in maintaining condylar position postoperatively. The findings suggest that either method can be effectively utilized in orthognathic surgery, with no significant superiority of one approach over the other. Further standardization in measurement protocols is recommended to enhance future comparative studies.

2026-01-01·Oral Surgery Oral Medicine Oral Pathology Oral Radiology

Long noncoding RNA DQ786243 and miRNA146a as potential salivary biomarkers for selected oral potentially malignant disorders: a diagnostic accuracy study

Article

作者: Shaker, Olfat ; Baz, Safaa ; Hafed, Layla ; Shalaby, Rania ; Afifi, Salsabeel ; Ibrahim, Sally ; Kotb, Ali Aw ; ElRefai, Sahar

OBJECTIVE:

Assess the diagnostic accuracy of salivary long noncoding RNA (lncRNA) DQ786243 and miRNA-146a as potential biomarkers for differentiating oral lichen planus (OLP) and oral leukoplakia (OL), both belonging to oral potentially malignant disorders (OPMDs), from healthy controls.

STUDY DESIGN:

Forty-five subjects were enrolled in a consecutive manner and allocated into 3 groups. Group I: 20 participants suffering from OLP. Group II: 15 patients with OL. Group III: 10 healthy controls. Expression of DQ786243 and miRNA146a in saliva was measured using quantitative real-time polymerase chain reaction. Reference standard was histopathological examination of OLP and OL.

RESULTS:

The greatest elevation of DQ8786243 and miRNA146a fold change (FC) occurred in OLP patients, especially erosive type, followed by OL group, whereas it was the lowest in healthy controls. Sensitivity and specificity of salivary DQ8786243 were 97.14% and 100%, respectively, at a cut point of 1.8 FC, delineating the difference between disease and control. Concerning miRNA146a, at a cut point of 1.4 FC, sensitivity and specificity were 94.29% and 100%, respectively.

CONCLUSIONS:

LncRNA DQ786243 and miRNA146a could be promising salivary biomarkers in the detection of OPMDs, especially OLP and OL. Salivary expression of both markers was the highest in erosive OLP.

项与 British University of Egypt 相关的新闻（医药）

2022-10-20

·NS Medical Devices

Swansea University to develop AI-based diagnostic tool for faster test results

Researchers at the British university have developed a proof of concept for a new diagnostic tool that could deliver health test results in two minutes using a fingertip sample The new diagnostic tool can deliver health test results in two minutes because of the use of AI and ML. (Credit: Swansea University) Scientists at the UK-based Swansea University are developing a new artificial intelligence (AI)-based diagnostic tool to speed up the process of biomarkers detection in biofluids. The researchers have developed a proof of concept for the new diagnostic platform that could deliver health test results in two minutes using a fingertip sample. According to the university, the test can enable faster test results for health issues like cardiovascular disorders, Alzheimer’s, and joint quality. Swansea University claimed that the diagnostic tool may revolutionise the healthcare industry because of the application of a form of AI and machine learning (ML). The ML can help in producing test results within minutes, said the university. Project lead Francesco Del Giudice said: “Existing technologies for the measurements of macromolecules in biofluids are limited; they require a long turnaround time, or require complex protocols, thus calling for alternative, more suitable, methodologies aimed at such measurements. “In our research, we looked at whether we could rapidly detect different concentration of macromolecules in solution at different temperatures using only 100 mL of sample (equivalent to 2 drops of blood). “The key innovation is the fact of providing a result within 2 minutes, which is a leap forward compared to standard testing that can take several hours.” Swansea University said that the proteins found in biofluids such as synovial fluid, saliva, and blood plasma serve as significant biomarkers for the identification of a number of medical disorders. It stated further that the specially created diagnostic tool has been engineered to detect the concentration of the proteins to aid in diagnosing and tracking disease development. According to the researchers, there is potential for at-home diagnostic kits in the future in which self-screening and self-monitoring options could be available and hospital wait times might be significantly reduced, Swansea University noted.

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