更新于：2024-11-01

Faculdade de Medicina de Marília

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www.famema.br

私营公司

更新于：2024-11-01

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项与 Faculdade de Medicina de Marília 相关的临床试验

RBR-1045xxpm / Active, not recruitingN/A

Effects of multidisciplinary educational intervention on the level of knowledge, quality of Life and self-care of elderly people with Diabetes Mellitus: a randomized clinical trial

开始日期2024-04-02

申办/合作机构

Faculdade de Medicina de Marília

[+1]

RBR-2k6xxs7 / Active, not recruitingN/A

Effects of Senior Dance® in elderly people with and without dementia: controlled clinical trial

开始日期2023-01-09

申办/合作机构

Faculdade de Medicina de Marília

[+1]

RBR-2gb34zr / Not yet recruitingN/A

Education actions and group Physiotherapy at the risk of falls in the elderly: Randomized clinical trial

开始日期2021-03-01

申办/合作机构

Faculdade de Medicina de Marília

[+1]

100 项与 Faculdade de Medicina de Marília 相关的临床结果

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0 项与 Faculdade de Medicina de Marília 相关的专利（医药）

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929

项与 Faculdade de Medicina de Marília 相关的文献（医药）

2024-11-01·Public Health

Increase in suicide rates in the elderly population of the state of São Paulo, Brazil: Could Alzheimer's disease be a risk factor?

Article

作者: Rubatino Rodrigues, Juliano Flávio ; de Araújo Filho, Gerardo Maria ; Rodrigues, Lívia Peregrino

OBJECTIVESIn recent years, there has been an increase in suicide rates in Brazil. From 2015 to 2019, a 34% increase in self-inflicted deaths was observed. The aim of this study was to analyse population data to determine whether some subgroups of the population, specifically the elderly population with Alzheimer's disease, are at a greater risk of suicide.STUDY DESIGNAn analysis of population data was carried out.METHODSPopulation data from the state of São Paulo, Brazil, were obtained from two platforms: the Brazilian Institute of Geography and Statistics (IBGE); and the Brazilian Ministry of Health (DataSUS). Data were measured and compared in 2010 and 2022 using the two most recent censuses.RESULTSBetween 2010 and 2022, the number of registered deaths of patients with Alzheimer's increased by 21.93%. In addition, there was a 100.37% increase in suicides among the elderly population compared to a 37.78% increase in the general population.CONCLUSIONSIn recent years, there has been a notable increase in both suicides among the elderly and mortality rates attributed to Alzheimer's disease within São Paulo state, Brazil. However, it is not possible to conclude that the increase in suicide among the elderly is directly linked to Alzheimer's disease. To determine a correlation between suicide and Alzheimer's disease, further studies are required.

2024-09-18·Naunyn-Schmiedeberg's archives of pharmacology

Mechanisms and effects of AdipoRon, an adiponectin receptor agonist, on ovarian granulosa cells-a systematic review.

Review

作者: Laurindo, Lívia Fornari ; Barbalho, Sandra Maria ; Catharin, Virgínia Maria Cavallari Strozze ; da Silva Camarinha Oliveira, Jéssica ; Laurindo, Lucas Fornari ; Chagas, Eduardo Federighi Baisi ; Rodrigues, Victória Dogani

Granulosa cells, crucial components of ovarian follicles, play a fundamental role in follicle development, hormone production, and overall reproductive health. These cells are integral to steroidogenesis, including the synthesis and secretion of key hormones such as estrogen and progesterone. Dysregulation of granulosa cells can lead to reproductive disorders, including polycystic ovary syndrome and infertility. This systematic review provides a comprehensive evaluation of AdipoRon, a synthetic agonist of adiponectin receptors AdipoR1 and AdipoR2, and its effects on ovarian function, with a particular focus on granulosa cells. Due to the absence of clinical trials, the review centers on preclinical studies to explore AdipoRon's potential therapeutic benefits and to suggest future research directions. A detailed literature search across databases such as PubMed, Scopus, Web of Science, Embase, and Google Scholar was conducted using terms related to AdipoRon and ovarian function. The review encompasses four preclinical studies involving various models: primary granulosa cells from rats, laying hens' granulosa cells, human luteinized granulosa cells, and chicken ovary follicles. Findings indicate that AdipoRon enhances glucose absorption in rat granulosa cells by stimulating glucose transporter 1 expression, modulates steroid hormone secretion in laying hens' granulosa cells, and affects cell proliferation and steroidogenesis in human luteinized granulosa cells. Additionally, AdipoRon, in conjunction with recombinant chicken adiponectin, influences ovarian follicular cell proliferation and steroidogenesis in chicken ovary follicles. This review highlights the need for further investigation into AdipoRon's long-term effects and its potential applications in reproductive health and therapy.

2024-09-01·The Journal of Nutritional Biochemistry

Pomegranate (Punica granatum L.) phytochemicals target the components of metabolic syndrome

Review

作者: Rodrigues, Victória Dogani ; DeLiberto, Lindsay K ; Minniti, Giulia ; Zutin, Tereza Laís Menegucci ; de Carvalho, Antonelly Cassio Alves ; Laurindo, Lucas Fornari ; Barbalho, Sandra Maria ; Bishayee, Anupam

Pomegranate (Punica granatum L.) is a multipurpose dietary and medicinal plant known for its ability to promote various health benefits. Metabolic syndrome (MetS) is a complex metabolic disorder driving health and socioeconomic challenges worldwide. It may be characterized by insulin resistance, abdominal obesity, hypertension, and dyslipidemia. This study aims to conduct a review of pomegranate's effects on MetS parameters using a mechanistic approach relying on pre-clinical studies. The peel, juice, roots, bark, seeds, flowers, and leaves of the fruit present several bioactive compounds that are related mainly to anti-inflammatory and antioxidant activities as well as cardioprotective, antidiabetic, and antiobesity effects. The use of the juice extract can work as a potent inhibitor of angiotensin-converting enzyme activities, consequently regulating blood pressure. The major bioactive compounds found within the fruit are phenolic compounds (hydrolysable tannins and flavonoids) and fatty acids. Alkaloids, punicalagin, ellagitannins, ellagic acid, anthocyanins, tannins, flavonoids, luteolin, and punicic acid are also present. The antihyperglycemia, antihyperlipidemia, and weight loss promoting effects are likely related to the anti-inflammatory and antioxidant effects. When considering clinical application, pomegranate extracts are found to be frequently well-tolerated, further supporting its efficacy as a treatment modality. We suggest that pomegranate fruit, extract, or processed products can be used to counteract MetS-related risk factors. This review represents an important step towards exploring potential avenues for further research in this area.

100 项与 Faculdade de Medicina de Marília 相关的药物交易

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100 项与 Faculdade de Medicina de Marília 相关的转化医学

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