Delving into the Latest Updates on Chitkara University with Synapse

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疾病领域	数量

神经系统疾病	1

排名前五的药物类型	数量

小分子化药	1

关联

1

项与 Chitkara University 相关的药物

TMF

靶点-

作用机制-

在研机构

Chitkara University

原研机构-

在研适应症

神经系统铅中毒

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

8

项与 Chitkara University 相关的临床试验

NCT06743633

/ Not yet recruitingN/AIIT

An Observational Study to Explore the Association Between Beta Blocker Use and Depressive Outcomes

An Observational Study to Explore the Association Between β-Blocker Use and Depressive Outcomes

开始日期2025-01-01

申办/合作机构

Chitkara University

CTRI/2023/04/051334

/ Not yet recruitingN/AIIT

A Randomized Control Trial to assess the effectiveness of selfmanagementprogram on Metabolic Syndrome risk reduction among middle and old-aged adults ofthe selected villages of Rajpura, Punjab.

开始日期2023-04-15

申办/合作机构

Chitkara University

CTRI/2018/01/011475

/ Not yet recruitingN/AIIT

EFFECT OF PERCEPTUAL COGNITIVE TRAINING USING VIRTUAL REALITY GAME THERAPY ON PERFORMANCE IN COLLEGIATE FIELD HOCKEY PLAYERS

开始日期2018-02-01

申办/合作机构

Chitkara University

100 项与 Chitkara University 相关的临床结果

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0 项与 Chitkara University 相关的专利（医药）

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9,480

项与 Chitkara University 相关的文献（医药）

2025-12-31·Journal of Taibah University for Science

Integrated microarray analysis of HPV of Mus musculus revealed the proteasome subunit beta type 6 gene as a potential biomarker

作者: Praveen, Mallari ; Gupta, Swanti ; Mujwar, Somdutt

2025-12-31·Artificial Cells, Nanomedicine, and Biotechnology

IRES activation: HK2 and TPI1 glycolytic enzymes play a pivotal role in non-neuronal cell survival under hypoxia

Article

作者: Devi, Sushma ; Hussain, Mahboob-Ul- ; Arora, Poonam ; Rahamathulla, Mohamed ; Banday, Muddasir Sharief ; Kumar, Manish ; Shivanandappa, Thippeswamy Boreddy ; Najar, Imtiyaz Ahmed ; Pasha, Ismail ; Ismail, Rehana ; Ahmed, Mohammed Muqtader

Hypoxia-induced brain damage can cause consciousness, memory failure and death. HK2 and TPI1 were investigated to see how they change hypoxia sensitivity in neurons and non-neurons. Hypoxia sensitivity is determined by the differential overexpression of both important glycolytic enzymes in neuronal and non-neuronal cells. C6 glioma cells expressed greater HK2 and TPI1 protein than neuro 2A cells, which were more sensitive to hypoxia-induced cell death by MTT and lactate dehydrogenase leakage assay. After 48 h of hypoxia, C6 glioma cells displayed substantial protein upregulation of HK2 and TPI1 glycolytic proteins but not mRNA. Hypoxia did not raise HK2 and TPI1 mRNA transcription, pointing at post-transcriptional protein regulation. Using di-cistronic and promoter-less di-cistronic assays, we discovered significant IRES regions in HK2 and TPI1 mRNA's 5'UTR, more active in C6 glioma cells with polypyrimidine tract binding (PTB) protein. We concluded that non-neuronal cells varied in HK2 and TPI1 overexpression, altering their vulnerability to hypoxia-induced cell death. Adjusting HK2, TP1 and PTB levels may prevent hypoxia-induced brain cell death. These results offer new information on glycolytic enzyme modulation under hypoxia, crucial for comprehending cell survival in hypoxic situations. This could affect situations like neurodegenerative illnesses or ischaemic injuries, where hypoxia-induced cell death is crucial.

2025-12-31·Materials Technology

Enhanced mechanical strength and biodegradability of PLA-based bioplastics reinforced with TiO ₂ and graphene oxide

作者: Kanan, Mohammad ; Giri, Jayant ; Saravanan, R. ; Sathish, T.

100 项与 Chitkara University 相关的药物交易

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100 项与 Chitkara University 相关的转化医学

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