Delving into the Latest Updates on Qinzhou No. 1 People's Hospital with Synapse

概览

关联

4

项与 Qinzhou No. 1 People's Hospital 相关的临床试验

Telitacicept Exploratory study of sequential rituximab in the treatment of Sjogren's syndrome with severe thrombocytopenia

开始日期2024-01-19

申办/合作机构

Qinzhou No. 1 People's Hospital

NCT06032819 / Not yet recruitingN/AIIT

Artificial Intelligence for Differentiating Between Brain Hemorrhage and Contrast Extravasation After Mechanical Revascularization in Acute Ischemic Stroke

The goal of this observational study is to use artificial intelligence to differentiate cerebral hemorrhage from contrast agent extravasation after mechanical revascularization in ischemic stroke.
The main question it aims to answer is: Whether artificial intelligence can help differentiate brain hemorrhage from contrast agent extravasation.
Patients with intracranial high-density lesions on CT scans within 24h after mechanical revascularization will be included. Expected to enroll 500 patients. The type of high-density lesion is determined according to dual-energy CT images or follow-up images. Patients will be divided into training group, validation and testing groups by stratified random sampling (6:2:2). After the images and the image labels are obtained, deep learning artificial intelligence will be used to learn the image characteristics and establish a diagnostic model, and the model performance and generalization ability will be evaluated.

开始日期2023-09-01

申办/合作机构

Sun Yat-Sen Memorial Hospital

[+7]

ChiCTR2300072385 / Suspended临床4期IIT

Application of Lactobacillin tablets in the prevention and treatment of oral mucositis during concurrent chemoradiotherapy in nasopharyngeal carcinoma

开始日期2023-07-01

申办/合作机构

Qinzhou No. 1 People's Hospital

100 项与 Qinzhou No. 1 People's Hospital 相关的临床结果

登录后查看更多信息

0 项与 Qinzhou No. 1 People's Hospital 相关的专利（医药）

登录后查看更多信息

10

项与 Qinzhou No. 1 People's Hospital 相关的文献（医药）

2021-12-01·Bulletin of Experimental Biology and Medicine4区 · 医学

Knockdown of Sirt1 Gene in Mice Results in Lipid Accumulation in the Liver Mediated via PGC-1α-Induced Mitochondrial Dysfunction and Oxidative Stress

4区 · 医学

Article

作者: Wang, Y ; Xu, S ; Su, D ; Liu, Y ; Yang, H

The study demonstrated the crucial role of Sirt1 gene in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) related to the influence of Sirt1 on oxidative stress and glycolipid metabolism. The 16-week-old genetically diabetic db/db mice were characterized with downregulated expression of Sirt1 in the liver accompanied by hepatomegaly and a larger size of fat vacuoles in hepatocytes. In db/m mice, silencing Sirt1 gene induced hepatic steatosis and significantly increased serum AST. Additionally, the levels of triglycerides in blood and liver of these mice were elevated. However, all pathological changes in the liver of Sirt1-knockdown db/m mice were less pronounced than in 16-week-old db/db mice. Further experiments showed that oxidative stress and PGC-1α-mediated mitochondrial dysfunction are implicated in pathological changes of lipid metabolism in T2DM-induced NAFLD provoked by Sirt1 silencing. This study showed that down-regulation of Sirt1 expression plays the key role in pathological processes developed during T2DM-induced abnormalities of lipid metabolism in the liver. Thus, up-regulation of Sirt1 expression seems to be a promising strategy in early prevention of T2DM-induced NAFLD.

2020-09-01·European review for medical and pharmacological sciences

Long noncoding RNA AFAP1-AS1 promoted osteosarcoma proliferation and invasion via upregulating BDNF.

Article

作者: Cheng, F-H ; Cai, L ; Zhao, B-M

Since this article has been suspected of research misconduct and the corresponding authors did not respond to our request to prove originality of data and figures, "Long noncoding RNA AFAP1-AS1 promoted osteosarcoma proliferation and invasion via upregulating BDNF, by B.-M. Zhao, F.-H. Cheng, L. Cai, published in Eur Rev Med Pharmacol Sci 2019; 23 (7): 2744-2749-DOI: 10.26355/eurrev_201904_17547-PMID: 31002124" has been withdrawn. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/17547.

2019-04-01·European review for medical and pharmacological sciences

Long noncoding RNA AFAP1-AS1 promoted osteosarcoma proliferation and invasion via upregulating BDNF.

Article

作者: Cheng, F-H ; Cai, L ; Zhao, B-M

OBJECTIVERecently, long noncoding RNAs (lncRNAs) have got much attention for their role in tumor progression. LncRNA AFAP1-AS1 was studied in this research to identify how it affects the development and proliferation of osteosarcoma.PATIENTS AND METHODSThe mRNA expression of AFAP1-AS1 in osteosarcoma cells and tissue samples was detected by quantitative real-time polymerase chain reaction (qRT-PCR). Moreover, cell proliferation assay and Matrigel assay were performed. Furthermore, the underlying mechanism was explored by using qRT-PCR and Western blot assay.RESULTSThe expression level of AFAP1-AS1 was higher in osteosarcoma samples than that in adjacent tissues. In addition, the proliferation and invasion were inhibited after AFAP1-AS1 was downregulated in vitro. Besides, the mRNA and protein expression levels of brain derived neurotrophic factor (BDNF) were reduced after downregulation of AFAP1-AS1. Furthermore, the expression level of BDNF was positively related to the expression of AFAP1-AS1 in osteosarcoma tissues.CONCLUSIONSAFAP1-AS1 could enhance the proliferation and invasion of osteosarcoma cells by upregulating BDNF, which might be a potential therapeutic target in osteosarcoma.

100 项与 Qinzhou No. 1 People's Hospital 相关的药物交易

登录后查看更多信息

100 项与 Qinzhou No. 1 People's Hospital 相关的转化医学

登录后查看更多信息