Continuous positive airway pressure (CPAP) is the mainstay of treatment recommended for preterm infants with respiratory distress syndrome in all resource contexts. Many of the available bubble CPAP machines in low- and middle-income contexts mix flows of air and oxygen. These are adjusted by two separate rotameters (flowmeters) and estimate FiO2 delivery. Medical decisions regarding interventions to sick neonates such as need for intubation or surfactant administration are in large part dependant on a reliable estimation of FiO2-delivery. The aim of this study is to evaluate the accuracy of FiO2 delivered by bubble-CPAP machines with separate oxygen and air rotameters in patients at a neonatal intensive care unit (NICU) in Hanoi.

开始日期2024-09-30

申办/合作机构

Karolinska Institutet

[+1]

NCT06606444 / RecruitingN/AIIT

A Single-arm, Prospective Feasibility Study of Placement and Surfactant Administration Through a Preterm Size Laryngeal Mask Airway in Very Low Birth Weight Neonates, with Respiratory Distress Syndrome, At a Level III Neonatal Intensive Care Unit in Hanoi, Vietnam

Surfactant administration via a supraglottic airway device or laryngeal mask airway (SALSA) is a minimally invasive method of instilling surfactant in the trachea during spontaneous breathing and after applying nasal continuous positive airway pressure (nCPAP). However, the procedure has been limited from use in very low birth weight neonates, due to lack of preterm size LMAs, which are now emerging on the market.
The goal of this study is to see if investigators can successfully use a new, smaller laryngeal mask airway (LMA) to place and give surfactant to premature babies with respiratory distress syndrome (RDS) who weigh between 750g and 1500g at birth.
The main objectives of the study are to:
* Check the placement of the new, smaller LMA: This includes evaluating the airway, how long it takes to place the LMA, how many attempts are needed, and the baby's stability during the process.
* Evaluate the administration of surfactant using the new LMA: Investigators will look at how the baby responds clinically, any changes in oxygen needs, how many doses of surfactant are required, the level of respiratory support needed, and whether intubation or mechanical ventilation is necessary.
* Ensure the safety of using the new LMA and administering surfactant: Investigators will monitor the baby's stability during the procedure and watch for any adverse events.
* Assess pain during the procedure: Investigators will evaluate pain levels using a pain scale based on video reviews.
Above objectives of feasibility are to be assessed before proceeding to a large randomize clinical trial assessing effectiveness and safety.

开始日期2024-09-20

申办/合作机构

Karolinska Institutet

[+1]

NCT06358885 / RecruitingN/AIIT

IGHID 12230 - Scaling up the Brief Alcohol Intervention to Prevent HIV Infection in Vietnam: a Cluster Randomized, Implementation Trial (EBAI)

This study is a hybrid type 3, cluster randomized implementation trial to examine effective strategies to scale up the Brief Alcohol Intervention (BAI) in ART clinics in Vietnam. One arm will receive only facilitation for BAI implementation. Facilitation is a flexible strategy that helps clinics to address common barriers, such as counselor skills, competing priorities, and resource deficits. In the other arm, in addition to facilitation, clinic staff, irrespective of their own alcohol use, will be offered the BAI themselves as experiential learning (EBAI) to address their own alcohol-related attitudes and behaviors. Clinic staff responsible for delivering the BAI to patients will also be offered 3 consolidation activities to integrate their own experiences with their delivery of the BAI.

开始日期2024-04-25

申办/合作机构

The University of North Carolina at Chapel Hill

[+5]

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项与 Hanoi Medical University 相关的文献（医药）

2024-12-31·Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization

Transfer learning for deep neural networks-based classification of breast cancer X-ray images

作者: Nguyen, Ngoc Cuong ; Nguyen, Hoang Phuong ; Le, Tuan Linh ; Ha, Manh Toan ; Bui, My Hanh ; Nguyen, Anh

2024-12-31·Future science OA

A consultation and work-up diagnosis protocol for a multicancer early detection test: a case series study.

Article

作者: Phuoc Dang, Ha Huu ; Ly Tran, Thi Huong ; Nguyen, Thanh Xuan ; Phan, Thanh Hai ; Phan, Van Bau ; Jasmine, Thanh Xuan ; Tang, Hung Sang ; Quyen Le, Thi Le ; Nguyen, Duy Sinh ; Tran, Vu ; Do, Thi Thanh-Thuy ; Pham, Nhu Hiep ; Tieu, Ba Linh ; Ha, Nhung Phuong ; Phan, Canh Duy ; Vo, Van Kha ; Pham, Van Dung ; Nguyen, Bao Toan ; Cao, Van Thinh ; Dang Nguyen, Luu Hong ; Le, Huu Linh ; Nguyen, Hoai-Nghia ; Phuong Doan, Thi Kim ; Phan, Thi Van ; Truong, Dinh Kiet ; Le, Minh Chi ; Thuy Pham, Thi Thu ; Nguyen, Lan Hieu ; Nguyen, Van Tung ; Bui, Vinh Quang ; Nhan Nguyen, Pham Thanh ; Nguyen, Huu Nguyen ; Tran, Van Khanh ; Phan, Ngoc Minh ; Truong, Cong Thanh ; Tran, Le Son ; Phan, Minh-Duy ; Nguyen, Huu Thinh ; Nguyen, Si Tuan ; Le, Van Hoi ; Nguyen, Thi Thanh ; Hanh Nguyen, Thi Hue ; Tran, Van Song ; Pham, Nguyen Tuong ; Luong, Thi Lan-Anh ; Tran, Tu Quy ; Huong Nguyen, Giang Thi ; Giang, Hoa ; Bui, Chi Viet ; Huynh, Minh Thien ; Truong, Quang Binh

The emergence of multicancer early detection (MCED) tests holds promise for improving early cancer detection and public health outcomes. However, positive MCED test results require confirmation through recommended cancer diagnostic imaging modalities. To address these challenges, we have developed a consultation and work-up protocol for definitive diagnostic results post MCED testing, named SPOT-MAS. Developed through circulating tumor DNA (ctDNA) analysis and in line with professional guidelines and advisory board consensus, this protocol standardizes information to aid general practitioners in accessing, interpreting and managing SPOT-MAS results. Clinical effectiveness is demonstrated through a series of identified cancer cases. Our research indicates that the protocol could empower healthcare professionals to confidently interpret circulating tumor DNA test results for 5 common types of cancer, thereby facilitating the clinical integration of MCED tests.

2024-12-31·Health Psychology and Behavioral Medicine

Associations of COVID-19-related fear with kidney disease quality of life and its subscales among hemodialysis patients as modified by health literacy: a multi-hospital survey

Article

作者: Duong, Tuyen Van ; Hoang, Trung A ; Phan, Dung T ; Nguyen, Lien T H ; Nguyen, Thao T P ; Ha, Tung H ; Do, Binh N ; Tran, Tu T ; Trieu, Nga T ; Do, Thinh V ; Pham, Linh V ; Nguyen, Dung H ; Nguyen, Kien T ; Dang, Loan T ; Le, Lan T H ; Nguyen, Hoi T ; Nguyen, Hoang C ; Pham, Minh D ; Trinh, Manh V

BackgroundReceiving hemodialysis treatment makes end-stage renal disease (ESRD) patients highly vulnerable amidst the COVID-19 pandemic. Hence, their kidney disease quality of life (KDQOL) is affected. We aimed to examine the association between fear of COVID-19 (FCoV-19) and KDQOL, and the effect modification of Health literacy (HL) on this association.Material and MethodsA survey was conducted at 8 hospitals from July 2020 to March 2021 on 972 patients. Data collection includes socio-demographic factors, clinical parameters, HL, digital healthy diet literacy (DDL), hemodialysis diet knowledge (HDK), FCoV-19, suspected COVID-19 symptoms (S-COVID-19-S), and KDQOL.ResultsHigher HL scores B = 0.13 (95% CI = 0.06-0.21, p = 0.001) and HDK scores B = 0.58 (95% CI = 0.31-0.85, p = 0.001) were associated with higher KDQOL scores. Whereas, S-COVID-19-S B = -6.12 (95% CI = -7.66 to - 4.58, p = 0.001) and FCoV-19 B = -0.91 (95% CI = -1.03 to - 0.80, p = 0.001) were associated with lower KDQOL scores. Notably, higher HL scores significantly attenuate the negative impact of FCoV-19 on overall KDQOL and the kidney disease component summary.ConclusionsIn hemodialysis patients, FCoV-19 and S-COVID-19-S were associated with a lower KDQOL. Health literacy significantly mitigates the negative impact of FCoV-19 on KDQOL. Strategic public health interventions to improve HL are suggested to protect patient's KDQOL during the pandemic.

项与 Hanoi Medical University 相关的新闻（医药）

2023-05-12

·Healthcare IT News

Lululab launching AI beauty research centre with Yonsei Cancer Center

South Korean AI beauty service startup Lululab has tied up with Yonsei Cancer Center's Scar Laser and Plastic Surgery Center to take their research partnership on the use of AI to treat skin diseases to a new level. The organisations recently signed a memorandum of understanding to set up a Skin AI Beauty Research Center. According to a press statement, the research centre will serve as Lululab's bedrock of AI solutions for diagnosing skin diseases optimised for hospitals. It plans to market its technology to its overseas clients, which make up 90% of its client base. The facility will also be utilising Lululab's own AI-powered skin analysis tool for conducting research on various skin diseases, such as scar, atopy, and acne, and on the development of skin disease solutions. Lululab will also make use of its own AI-based customer relationship management system, which links skin analysis reports and treatment information to medical devices. WHY IT MATTERS Through the research centre, Lee Joo-hee, its upcoming head, said a predictive model to determine the potential effects of scarring and cosmetic treatments will be developed. He expects the technology to be applied to clinical practice soon. THE LARGER CONTEXT The latest MOU builds on Lululab's existing partnership with Yonsei University Severance Hospital where they jointly worked on a skin diseases database and AI-based tools for analysing skin diseases, including atopy, psoriasis, and vitiligo. Some of those AI tools are said to be ready for commercialisation. Outside South Korea, Lululab has another research partnership with Hanoi Medical University in Vietnam to co-develop similar AI-based skin disease analysis solutions, enabling the precise diagnosis of various skin diseases in the country.

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