The aim of the current intervention study is to determine the effectiveness of taurine containing eye drops (available under brand name VIZILOTON) to prevent the progression of grade I and II senile cataract.
This study could answer:
* Dose continuous use of taurine-containing eye drops could prevent further deterioration of vision in mild cases of cataract?
* The acceptance/ compliance of participants to taurine-containing eye drops.
* Could long-term use of taurine-containing eye drops cause adverse effect(s)?
Participants will:
* Take taurine-containing eye drops (VIZILOTON eye drops) 4 times a day for one year.
* Visit eye clinic every 3 months for assessment and visual examination.
* Keep notes for their symptoms and their adherence to treatment.

开始日期2023-07-10

申办/合作机构

University of Anbar

NCT04569825

/ Unknown status早期临床1期IIT

Effect of Nasal Steroid in the Treatment of Anosmia Due to COVID-19 Disease

Background: Anosmia is a debilitating common symptom of COVID-19. The therapeutic effect of systemic steroid for the treatment of anosmia has been studied with various findings of its efficacy. However, the effect of local steroid was not assessed before.
Objective: To estimate the efficacy of local steroid in the treatment of anosmia in COVID-19 patients.

开始日期2020-08-01

申办/合作机构

University of Anbar

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项与 University of Anbar 相关的文献（医药）

2025-12-31·Energy Sources, Part A: Recovery, Utilization, and Environmental Effects

Numerical simulation of heat transfer improvement of a new designed artificially roughened solar air heater using triangular ribs with semi-circular nooks

作者: Ahmed, Hamdi ; Laouedj, Samir ; Zina, Boucif ; Filali, Abdelkader ; Benamara, Nabil

The present study represents a computational anal. of two-dimensional air flow in a new designed configuration of a solar air heater (SAH).The shape of the installed ribs along the absorber plate is a combination of triangular and semi-circular nooks with variable height of three ribs simultaneously.The objective is to optimize the Thermo-Hydraulic Efficiency Parameter (THEP) of the SAH by characterizing the values of roughness height (e) and pitch (P) of the considered ribs which provides the optimum patterns.Various (e) and (P) values for varied Reynolds number (Re) between 3,800 and 18,000 are investigated.An imposed constant heat flux is considered, and governing equations describing the flow and heat transfer are solved numerically with the selected RNG k-ε for the turbulence modeling.The obtained results indicate that the THEP strongly depends on the different investigated geometric parameters and Re numberThe obtimum THEP value of 1.93 could be obtained for the case C1 and Re number of 5,000.

2025-05-01·Journal of Molecular Structure

Synthesis, characterization, molecular docking, and computational study of novel spirothiazolidinone compounds

作者: Mahdi, Omar J. ; Bichan, Mustafa J. ; Mukhlif, Mohammed G.

An essential component in the formation of organic mols. is cyclohexanone.This makes cyclohexanone a good choice for use in organic synthesis because the carbonyl group is very reactive and has a prochiral center.Constructing a spiroheterocyclic framework for organic chemists has always been challenging because it typically involves synthetic design based on specific techniques.The acid-catalyzed condensation of aromatic amines and cyclohexanone produced several Schiff bases.We synthesized novel spirothiazolidinone derivatives from these bases by cyclizing them with thioglycolic acid (TGA) in an inert anhydrous solvent.We employed FTIR, ¹H NMR, and mass spectroscopy to analyze and describe the synthesized compounds after recrystallizationFurthermore, we conducted a theor. anal. using Gaussian software to investigate the effects of the para-substituted amine on the structure of the resultant product, applying d. functional theory (DFT) using the B3LYP method and cc-pVTZ basis set to estimate global reactivity descriptors.Finally, in silico docking simulation with a flexible approach has been used to predict their biol. activity on angiotensin-converting enzyme (ACE).The findings demonstrated the interaction of these compounds with the ACE′s amino acid residue and were compared to the reference medication lisinopril.

2025-05-01·Journal of Molecular Modeling

Investigation impact of (Ni, Cu) co-doping on the electronic, optical, magnetic, and I-V characteristics of GaP nanosheets

Article

作者: Nawaf, Sameer ; Al-Jobory, Alaa A ; Motlak, Moaaed

CONTEXTThe impact of the combination of transition metals on the electronic, optical, magnetic, and I-V characteristics of GaP nanosheet was carried out by first-principles density functional theory (DFT) with nonequilibrium green's function calculations. The band energy results of the GaP structure showed a semiconductor feature with a direct band gap of 1.29 eV. The electronic structures and the density of Ni- and Cu-doped states and (Ni-Cu) co-doped GaP were investigated. It exhibited that the impurity states are crucial in their impact on modifying the electronic properties of the system as the electron transfer rate can be enhanced. On the other hand, a pristine and Cu-doped GaP nanosheet represents a nonmagnetic semiconductor due to the polarized DOS in both spins' directions displaying similarity. At the same time, the polarized DOS of Ni-doped GaP nanosheet displays a ferromagnetic phase. For (Ni-Cu) Co-doped GaP nanosheet, the resulting material shows the total density of states for both spin states is different and implies the presence of magnetic moments. The optical results showed that the Cu-doped GaP displays a shift in the absorption edge compared to pristine GaP. Also, the co-doped system displays a smoother absorption spectrum with reduced intensity in the peak region, indicating a combined effect of both dopants. The Ni-doped GaP displays the highest conductivity with the current reaching around ± 100,000 nA. This suggests that Ni has a more significant effect in enhancing charge transport.METHODSDensity functional theory (DFT) with a nonequilibrium green's function approach was utilized to calculate the electronic, optical, magnetic, and I-V characteristics of the GaP nanosheet. The results of the electronic, optical, and magnetic properties were evaluated by applying the SIESTA package. I-V characteristics were evaluated by using the quantum transport code "GOLLUM."

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