A 12 week, multi-center, double-blind, randomized, placebo-controlled clinical trial for the evaluation of the efficacy and safety of BRB-F on improving liver function

开始日期2015-09-01

申办/合作机构

STR Biotech Co., Ltd.

KCT0002004

/ CompletedN/A

A 4 week, double-blind, randomized, placebo-controlled clinical trial for the evaluation of the efficacy and safety of UL-F on allergic rhinitis

开始日期2015-03-26

申办/合作机构

STR Biotech Co., Ltd.

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2025-02-28·Journal of the Korean Society of Food Science and Nutrition

Effect of Bioprocessed Black Rice Bran on Muscle Strength in a Dexamethasone-Induced Muscle Atrophy C2C12 Model

作者: Song, Tae-Woong ; Song, Aram ; Kim, Sung Phil ; Lee, Ok-Hwan ; Choi, Sun-Il ; Cho, Geun-Hee ; Ko, Da-Hyun

Muscle atrophy caused by aging, obesity, and inflammation has become a prominent global concern, prompting increased interest in developing functional food ingredients to address this issue.This study investigated the efficacy of bioprocessed black rice bran extract, a byproduct of black rice processing, on enhancing muscle strength by treating a dexamethasone-induced muscle atrophy model during the differentiation of C2C12 myotubes with bioprocessed black rice bran (BRB-F-S).To evaluate the cytotoxicity of BRB-F-S, cell viability was measured using the 2,3-bis-(2-methoxy-4-nitro-5-sulphenyl)-(2H)-tetrazolium-5-carboxanilide (XTT) assay.Addnl., the cytoprotective effects of BRB-F-S against dexamethasone-induced muscle atrophy were quant. assessed via relative cell viability and myotube formation.The study results indicated that the BRB-F-S-treated group not only provided statistically significant protection against dexamethasone-induced cytotoxicity but also improved myotube formation.Furthermore, to investigate the mechanisms underlying the effects of BRB-F-S on myotube formation, an anal. of protein expression was carried out which revealed a significant increase in the levels of sirtuin 1, AMP-activated protein kinase alpha, protein kinase B, and mammalian target of rapamycin, which are proteins associated with mitochondrial biogenesis and protein synthesis, while expression levels of forkhead box class O 3a, atrogin1, and muscle RING-finger protein-1, related to protein degradation and the ubiquitin-proteasome system, were significantly reduced.These findings suggest that BRB-F-S could serve as a potential ingredient for health functional foods aimed at improving muscle atrophy.

2025-02-01·Food Science and Biotechnology

Anti-obesogenic effect of standardized Brassica juncea extract on bisphenol A-induced 3T3-L1 preadipocytes and C57BL/6J obese mice

Article

作者: Fu, Xiaolu ; Oh, Geon ; Choi, Sun-Il ; Men, Xiao ; Hwang, Woon Sang ; Hwang, Woon sang ; Han, Xionggao ; Lim, June seok ; Cho, Geun hee ; Cho, Geun Hee ; Im, Ji-Hyun ; Lee, Ok-Hwan ; Lim, June Seok

Bisphenol A (BPA) is a representative obesogen that induces adipocyte differentiation and lipid accumulation by mimicking the action of hormones. Brassica juncea is a plant belonging to the mustard family, and has antioxidant, anti-inflammatory, and anti-obesity effects. However, its efficacy against obesogen-induced obesity requires further investigation. In this study, we investigated the anti-obesogenic effects of Brassica juncea extract (BJE) on BPA-treated 3T3-L1 preadipocytes and C57BL/6J mice. The treatment with BPA and BJE did not have cytotoxic effects in vitro. In addition, BJE inhibited BPA-induced lipid accumulation and suppressed BPA-induced changes in adipocyte differentiation, adipogenesis, and lipolysis protein expression in 3T3-L1 cells. Oral administration of BJE reduced body weight, adipose tissue mass, and adipocyte size in BPA-induced obese C57BL/6 mice. BJE also regulated the expression of proteins involved in adipocyte differentiation, adipogenesis, and lipolysis. These data demonstrate that BJE is a natural functional substance with anti-obesogenic effects.

2024-12-31·Pharmaceutical Biology

Rice bran arabinoxylan compound as a natural product for cancer treatment – an evidence-based assessment of the effects and mechanisms

Review

作者: Kim, Jeanman ; Micalos, Peter S. ; Ooi, Soo Liang ; Pak, Sok Cheon

CONTEXTRice bran arabinoxylan compound (RBAC) is a natural immunomodulator with anticancer properties.OBJECTIVEThis study critically evaluates the available evidence on the biological pathways of RBAC and its effects on cancer treatment.METHODSThis secondary analysis of a scoping review includes studies evaluating the mechanisms of RBAC on healthy or malignant cells, animal models, or humans for cancer prevention or treatment. Data from randomized controlled trials on survival and quality of life outcomes were subjectd to meta analysis.RESULTSThe evidence synthesis was based on 38 articles. RBAC exhibited antitumor properties by promoting apoptosis and restoring immune function in cancer patients to enhance inflammatory and cytotoxic responses to block tumorigenesis. RBAC works synergistically with chemotherapeutic agents by upregulating drug transport. In a clinical trial, combining RBAC with chemoembolization in treating liver cancer showed improved response, reduced recurrence rates, and prolonged survival. RBAC also augments the endogenous antioxidant system to prevent oxidative stress and protect against radiation side effects. In addition, RBAC has chemoprotective effects. Animals and humans have exhibited reduced toxicity and side effects from chemotherapy. Meta analysis indicates that RBAC treatment increases the survival odds by 4.02-times (95% CI: 1.67, 9.69) in the first year and 2.89-times (95% CI: 1.56, 5.35) in the second year.CONCLUSIONRBAC is a natural product with immense potential in cancer treatment. Additional research is needed to characterize, quantify, and standardize the active ingredients in RBAC responsible for the anticancer effects. More well-designed, large-scale clinical trials are required to substantiate the treatment efficacies further.

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