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项与 Xi'an No.1 Hospital 相关的临床试验

ChiCTR2300070461 / Recruiting早期临床1期IIT

Clinical Outcomes of Allogenic Stromal Lenticule Addition Keratoplasty Combined with Crosslinking in Keratoconus

开始日期2021-10-21

申办/合作机构

Xi'an No.1 Hospital

NCT04881292 / Unknown statusN/AIIT

Reference Values of Carotid Intima-media Thickness and Arterial Stiffness in Chinese Adults Based on Ultrasound Radio Frequency Signal: A Nationwide, Multicenter Study

This study intends to establish the normal reference values of carotid artery intima-media thickness and vascular elasticity of Chinese adults based on ultrasound radio frequency technology through a multi-center large-sample study, which provides important information for the risk prediction and prognosis evaluation of Chinese adults' cardiovascular disease.

开始日期2021-05-01

申办/合作机构

Tangdu Hospital

[+20]

ChiCTR2100043255 / Recruiting早期临床1期IIT

Experimental study on treatment of dry eye in mice with exosomes from human cord blood

开始日期2021-03-15

申办/合作机构

Xi'an No.1 Hospital

100 项与 Xi'an No.1 Hospital 相关的临床结果

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0 项与 Xi'an No.1 Hospital 相关的专利（医药）

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220

项与 Xi'an No.1 Hospital 相关的文献（医药）

2024-12-31·Human Vaccines & Immunotherapeutics

Letter to the editor to ‘Clinical characteristics and risk factors for ZF2001 fully vaccinated inpatients with COVID-19: A retrospective cohort study’

作者: Gao, Jie ; Wang, Yu

2024-12-01·Molecular Biology Reports

The role of ApoE in fatty acid transport from neurons to astrocytes under ischemia/hypoxia conditions

Article

作者: Chen, Hongyan ; Wang, Simin ; Yan, Yinfang ; Zhao, Shaozhi ; Jian, Qiang ; Ji, Yuqiang ; Zhang, Xinwen

BACKGROUNDThe aim of this study was to investigate whether ischemia/hypoxia conditions induce fatty acid transport from neurons to astrocytes and whether this mechanism is affected by ApoE isoforms.METHODS AND RESULTSA neonatal rat model of hypoxic-ischemic brain damage was established. Excessive accumulation of lipid droplets and upregulation of ApoE expression occurred in the hippocampus and cerebral cortex after hypoxia-ischemia, which implied the occurrence of abnormal fatty acid metabolism. Lipid peroxidation was induced in an oxygen-glucose deprivation and reperfusion (OGDR) model of ApoE^-/- primary neurons. The number of BODIPY 558/568 C12-positive particles (fatty acid markers) transferred from neurons to astrocytes was significantly increased with the addition of human recombinant ApoE compared with that in the OGDR group, which significantly increased the efficiency of fatty acid transport from neurons to astrocytes and neuronal viability. However, ApoE4 was found to be associated with lower efficiency in fatty acid transport and less protective effects in OGDR-induced neuronal cell death than both ApoE2 and ApoE3. COG133, an ApoE-mimetic peptide, partially compensated for the adverse effects of ApoE4. FABP5 and SOD1 gene and protein expression levels were upregulated in astrocytes treated with BODIPY 558/568 C12 particles.CONCLUSIONSIn conclusion, ApoE plays an important role in mediating the transport of fatty acids from neurons to astrocytes under ischemia/hypoxia conditions, and this transport mechanism is ApoE isoform dependent. ApoE4 has a low transfer efficiency and may be a potential target for the clinical treatment of neonatal hypoxic-ischemic encephalopathy.

2024-11-01·Combinatorial Chemistry & High Throughput Screening

Network Pharmacology and Molecular Docking Analysis on Mechanisms of Scutellariae Radix in the Treatment of Cerebral Ischemia-reperfusion Injury

Article

作者: Bai, Lu ; Yang, Yang ; Yuan, Wenting ; Hou, Yongqiang ; Duan, Shiwan ; Xu, Mengrong ; Feng, Yue ; Fang, Fei

Background:Multiple brain disorders are treated by Scutellaria Radix (SR), including cerebral ischemia-reperfusion (CI/R). However, more studies are needed to clarify the molecular mechanism of SR for CI/R.Methods:The active substances and potential targets of SR and CI/R-related genes were obtained through public databases. Overlapping targets of SR and CI/R were analyzed using proteinprotein interaction (PPI) networks. GO and KEGG enrichment analyses were performed to predict the pathways of SR against CI/R, and the key components and targets were screened for molecular docking. The results of network pharmacology analysis were verified using in vitro experiments.Results:15 components and 64 overlapping targets related to SR and CI/R were obtained. The top targets were AKT1, IL-6, CAS3, TNF, and TP53. These targets have been studied by GO and KEGG to be connected to a number of signaling pathways, including MAPK, PI3K-Akt pathway, and apoptosis. Molecular docking and cell experiments helped to further substantiate the network pharmacology results.Conclusion:The active compound of SR was able to significantly decrease the apoptosis of HT22 cells induced by OGD/R. This finding suggests that SR is a potentially effective treatment for CI/R by modulating the MAPK and PI3K-Akt pathways.

100 项与 Xi'an No.1 Hospital 相关的药物交易

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100 项与 Xi'an No.1 Hospital 相关的转化医学

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