Comparative analysis of diaphragmatic thickness fraction with parasternal muscle thickness fraction by the use of ultrasonography for predicting weaning in adults receiving mechanical ventilation. - NIL

开始日期2024-08-30

申办/合作机构

Government Medical College

100 项与 Government Medical College 相关的临床结果

登录后查看更多信息

0 项与 Government Medical College 相关的专利（医药）

登录后查看更多信息

1,405

项与 Government Medical College 相关的文献（医药）

2024-12-01·Obesity Pillars

Bariatric surgery association with risk of recurrent stroke hospitalization among older stroke survivors with obesity: A national inpatient sample study (2016–2019)

Article

作者: Sunkara, Praveena ; Sundaram, Dakshin Meenashi ; Thompson-Edwards, Ashley ; Vanani, Samir ; Dhavapalani, Dhayashri ; Anand, Dharshana Prem ; Rajarajan, Srinishant ; Babu, Kalaivani ; Vasavada, Advait ; Mahadevan, Arankesh ; Desai, Rupak ; Reyaz, Nafisa ; Garikipati, Sushmitha

Background and aimsThe paucity of large-scale data exploring the effect of prior bariatric surgery on recurrent stroke outcomes in older individuals with obesity who survived a stroke led us to address the gap, with an emphasis on the risk of recurrent stroke and its trends.MethodsRetrospective analysis of the National Inpatient Sample data from 2016 to 2019. Older individuals with obesity who survived a stroke (>65 years) and had a recurrent acute ischemic stroke (AIS) hospitalization, with or without prior bariatric surgery (PBS), were identified using ICD-10 codes. Recurrent stroke trends, demographic characteristics, and comorbidities between the cohorts were compared.ResultsAnalyzing 643,505 older individuals with obesity who survived a stroke, we identified that 11,820 had undergone PBS. Both groups (no PBS vs. PBS) were predominantly female (59.7 % vs. 73.7 %), identified as white (76.5 % vs. 83.8 %), and covered by Medicare (91.7 % vs. 90.7 %). Diabetes, hyperlipidemia, prior myocardial infarction, and peripheral vascular diseases were more common in those without PBS. In contrast, tobacco use disorder, drug abuse, and valvular diseases were more common in those with PBS. There was no significant difference in the prevalence of hypertension between groups.Between 2016 and 2019, recurrent AIS hospitalizations were less frequent in the PBS group (4 %-2.9 %, p = 0.035) while remaining stable in the other group (4.4 %-4.2 %, p = 0.064). The risk of recurrent AIS hospitalization was less frequent in the PBS cohort (aOR: 0.77, 95 % CI: 0.60-0.98).ConclusionPBS in older individuals with obesity who survived a stroke was associated with a 23 % lower risk of recurrent AIS hospitalization with a decreasing trend of prevalence since 2016. These findings could influence clinical practice and contribute to developing secondary prevention strategies for recurrent stroke among these patients.

2024-11-01·Anti-Cancer Agents in Medicinal Chemistry

A Novel Combinatorial Regimen Using Sorafenib and Uttroside B, A US FDA-designated ‘Orphan Drug’, for the Treatment of Hepatocellular Carcinoma

Article

作者: Keerthana, Chenicheri Kizhakkeveettil ; Vijayan, Yadu ; Shifana, Sadiq C. ; Rayginia, Tennyson P. ; Harikumar, Kuzhuvelil B. ; Lankalapalli, Ravi S. ; Induja, D.K. ; James, Shirly ; Anto, Ruby John ; Aiswarya, Sreekumar U. ; Sundaram, Sankar

Introduction:Sorafenib (Sor) is the first-line treatment option in clinics for treating advanced unresectable hepatocellular carcinoma (HCC). However, acquired chemoresistance and adverse side effects associated with Sor monotherapy limit its clinical benefits. We have previously reported the exceptional anti-HCC potential of uttroside B (Utt-B), a furostanol saponin isolated in our lab from Solanum nigrum Linn. leaves. The current study has evaluated the supremacy of a combinatorial regimen of Sor and Utt-B over Sor monotherapy.Methods:MTT assay was used for In vitro cytotoxicity studies. A clonogenic assay was conducted to assess the anti-proliferative effect of the combination. Annexin V/PI staining, confocal microscopy, FACS cell cycle analysis, and Western blotting experiments were performed to validate the pro-apoptotic potential of the combination in HepG2 and Huh7 cell lines. Pharmacological safety evaluation was performed in Swiss albino mice.Results:Our results indicate that Utt-B augments Sor-induced cytotoxicity in HepG2 and Huh7 cells. The combination inhibits the proliferation of liver cancer cells by inducing apoptosis through activation of the caspases 7 and 3, leading to PARP cleavage. Furthermore, the combination does not induce any acute toxicity in vivo, even at a dose five times that of the effective therapeutic dose.Conclusion:Our results highlight the potential of Utt-B as an effective chemosensitizer, which can augment the efficacy of Sor against HCC and circumvent Sor-induced toxic side effects. Moreover, this is the first and only report to date on the chemosensitizing potential of Utt-B and the only report that demonstrates the therapeutic efficacy and pharmacological safety of a novel combinatorial regimen involving Utt-B and Sor for combating HCC.

2024-11-01·Current Drug Targets

Beta-Hydroxybutyrate: A Supplemental Molecule for Various Diseases

Article

作者: Jain, Subheet Kumar ; Shahtaghi, Navid Reza ; Soni, Bindu ; Bakrey, Hossamaldeen ; Bigdelitabar, Samira

:β-hydroxybutyrate (BHB) is a ketone body that serves as an alternative energy source for various tissues, including the brain, heart, and skeletal muscle. As a metabolic intermediate and signaling molecule, BHB plays a crucial role in modulating cellular and physiological processes. Notably, BHB supplementation offers a novel and promising strategy to induce nutritional ketosis without the need for strict dietary adherence or causing nutritional deficiencies. This review article provides an overview of BHB metabolism and explores its applications in age-related diseases. This review conducted a comprehensive search of PubMed, ScienceDirect, and other relevant English-language articles. The main findings were synthesized, and discussed the challenges, limitations, and future directions of BHB supplementation. BHB supplementation holds potential benefits for various diseases and conditions, including neurodegenerative disorders, cardiovascular diseases, cancers, and inflammation. BHB acts through multiple mechanisms, including interactions with cell surface receptors, intracellular enzymes, transcription factors, signaling molecules, and epigenetic modifications. Despite its promise, BHB supplementation faces several challenges, such as determining the optimal dosage, ensuring long-term safety, identifying the most effective type and formulation, establishing biomarkers of response, and conducting cost-effectiveness analyses. BHB supplementation opens exciting avenues for research, including investigating molecular mechanisms, refining optimization strategies, exploring innovation opportunities, and assessing healthspan and lifespan benefits. BHB supplementation represents a new frontier in health research, offering a potential pathway to enhance well-being and extend lifespan.

项与 Government Medical College 相关的新闻（医药）

2024-04-12

·PRNewswire

The Inner Circle acknowledges Tanveer P. Mir, MD, MACP as a Pinnacle Lifetime Member

GLEN COVE, N.Y., April 12, 2024 /PRNewswire/ -- Prominently featured in The Inner Circle, Tanveer P. Mir, MD, MACP is acknowledged as a Pinnacle Lifetime Member for her contributions as a Respected Leader in Medicine and Administration. Dr. Tanveer P. Mir, a highly esteemed professional with a remarkable career in the medical field, has earned accolades for expertise in both medicine and healthcare administration. Her dedication to patient care and her leadership in healthcare institutions have solidified her reputation as a respected figure in the industry. Continue Reading Tanveer P. Mir, MD, MACP Currently serving as the Chairperson at NYC Health + Hospitals/South Brooklyn Health, Ruth Bader Ginsburg Hospital, Dr. Mir oversees various administrative functions of the facility. In addition to her administrative role, she provides clinical care, with a particular focus on in-patient geriatrics, utilizing a comprehensive holistic approach to patient well-being. Dr. Mir's expertise lies in the field of geriatrics, where her knowledge and compassionate care have had a significant impact on the health and well-being of her patients. She is deeply committed to providing the highest quality of care to the elderly population, addressing their unique healthcare needs. Her educational journey began at the Government Medical College in Kashmir, India, where she completed her pre-medical studies and earned her MBBS (Bachelor of Medicine, Bachelor of Surgery) in 1980. She pursued further training by completing her residency in internal medicine at Long Island Jewish Medical Center in New Hyde Park, NY, and subsequently served as Chief Resident at Nassau University Medical Center. Dr. Mir holds board certifications in multiple medical specialties, including internal medicine, geriatric medicine, and hospice and palliative care. These certifications underscore her commitment to excellence and her dedication to providing specialized care to her patients. An active member of professional organizations, Dr. Mir has been honored with the distinction of Master of the American College of Physicians (MACP), a significant achievement in the medical field. She is also affiliated with the American Geriatric Society, further demonstrating her commitment to advancing the field of geriatrics. Throughout her extensive career, Dr. Mir has held pivotal roles in various healthcare institutions, including the North Shore-Long Island Jewish Health System, North Shore University Hospital, Hospice Care Network in Long Island, and Long Island Jewish Medical Center. Her leadership and expertise have made a lasting impact on the organizations she has served. Outside of her professional endeavors, Dr. Mir enjoys gardening, reading, and indulging in interior design. She is also dedicated to community service and has volunteered her time with the local food pantry, demonstrating her commitment to giving back to the community. Dr. Mir has been fortunate to have the guidance and mentorship of esteemed professionals throughout her career. She fondly remembers her mentors, including Faith Fitzgerald, MD, MACP, Steven Kamholz, MD, MACP, and Faroque Khan, MD, who have played pivotal roles in shaping her career. In her personal life, Dr. Mir is happily married to Parvez Mir, MD, and they are proud parents to two daughters and one son. As Dr. Mir looks to the future, she remains dedicated to providing exceptional care to her patients and continuing her leadership in healthcare administration. Her unwavering commitment to patient well-being and her impressive career achievements serve as an inspiration to her colleagues and the broader medical community. Contact: Katherine Green, 516-825-5634, [email protected] SOURCE The Inner Circle