Randomization of Sodium Alginate and Mosapride Citrate for Patients with Gastroesophageal Reflux Disease (GERD) Following Distal Gastrectomy with Billroth I Reconstruction - A Multicenter Comparative Study - Randomization of Sodium Alginate and Mosapride Citrate for Patients with Gastroesophageal Reflux Disease (GERD) Following Distal Gastrectomy with Billroth I Reconstruction - A Multicenter Comparative Study

开始日期2006-10-01

申办/合作机构

Kyosei Pharmaceutical Co., Ltd.

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2006-07-01·Journal of Natural Medicines4区 · 医学

Two fucoidans in the holdfast of cultivated Laminaria japonica

4区 · 医学

Article

作者: Yamamoto, Jynji ; Yamagishi, Takashi ; Ozawa, Tomohiro ; Nishizawa, Makoto ; Yamazaki, Noriyuki

Two fucoidans have been isolated from the holdfast of cultivated Laminaira japonica. One (L-fucoidan) is rich in fucose and sulfate; the other (GA-fucoidan) is rich in uronate. L-fucoidan was found in the fronds of L. japonica (cultivated and wild), L. angustata, and Kjellmaniella crassifolia whereas GA-fucoidan was not detected in these fronds and may be a fucoidan specific to the holdfast. These two fucoidans were proved to have anti-tumor activity against Adenocarcinoma 755-transplanted mice by i.p. and p.o. administration.

2000-06-01·Phycological Research

Guluronate content of alginate in Laminaria japonica and Laminaria angustata fronds in laboratory culture

作者: Motomura, Taizo ; Nishizawa, Makoto ; Tatewaki, Masakazu ; Shinohara, Masashi ; Bando, Hideo ; Nishida, Ryuichi

The guluronate (G) content of alginate in the fronds of Laminaria japonica and Laminaria angustata, cultured in the laboratory from zoospore via gametophyte using PESI medium, was determined by the ¹H-NMR spectroscopic method.The G content of alginates in young fronds cultured in various conditions were shown to exceed 55%.These values were remarkably higher than those in field kelp.The G content increased with extending culture period and at low temperature

1999-01-01·Fisheries science

Relationships between Guluronate Contents in Alginates Determined by <sup>1</sup>H-NMR Spectroscopy and Their Average Molecular Weights

作者: Nishizawa, Makoto ; Aoyama, Takako ; Kamono, Hideki ; Shinohara, Masashi ; Bando, Hideo

The relationships between guluronate content (G%) in alginates determined by ¹H-NMR spectroscopy and their weight average mol. weight (WAMW) were examined to evaluate the reliability of the ¹H-NMR method.The partially hydrolyzed alginates with WAMW of 15k, 30k, 45k, 60k and 100k were prepared from alginates with WAMW of 150∼200k by autoclaving.The G% in the partially hydrolyzed alginates determined by ¹H-NMR spectroscopy were independent on their WAMW, when the G% was less than 70%.The ¹H-NMR spectroscopic method using partially hydrolyzed alginates prepared by hydrolysis in an autoclave might be a convenient and reliable for the determination of G% in alginates.

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