Introduction::Clinical trials indicate that IDegLira is effective in treating type 2 diabetes
mellitus (T2DM). This study aims to assess the efficacy and safety of IDegLira in type 2 diabetes
mellitus (T2DM) comprehensively.
Methods::To identify relevant randomized controlled trials, we searched PubMed, Embase,
Cochrane Library, Web of Science, and ClinicalTrials.gov. Risk Ratios (RR) and 95% Confidence
Intervals (CI) were calculated using the Mantel-Haenszel approach for dichotomous outcomes.
Mean Difference (MD) and 95% CI calculated by the inverse variance approach were applied to
continuous outcomes.
Results::Twelve randomized controlled trials involving 7628 participants were included in this
study. Compared with control groups, IDegLira has a significant hypoglycemic effect in reducing
hemoglobin A1c (MD = −0.66; 95% CI [−0.85, −0.47]; p < 0.00001), fasting plasma glucose (MD
= −0.90; 95% CI [−1.40, −0.41]; p = 0.0003), self-measured plasma glucose (MD = −0.82; 95%
CI [−1.22, −0.42]; p < 0.0001) and achieving the hemoglobin A1c level of < 7.0%(RR = 1.66;
95% CI [1.44, 1.92]; p < 0.00001) or < 6.5% (RR = 2.13; 95% CI [1.76, 2.57]; p < 0.00001).
IDegLira outperforms insulin in achieving the target of HbA1c < 7.0 or < 6.5% without hypoglycemia
and weight gain. Besides, IDegLira did not increase the incidence of adverse events and
serious adverse events.
Discussion::In this section, IDegLira’s benefits on simultaneously achieving glycemic control,
weight loss, and reduced hypoglycemia risk were summarized. The statistical results were carefully
interpreted in conjunction with clinical concerns regarding T2DM complications, adverse effects,
and cost-effectiveness differences. An expanded discussion was conducted on integrating individualized
HbA1c goals as a dual endpoint, without increasing body weight or the risk of hypoglycemia.
Finally, the limitations of the present study are indicated.
Conclusions::IDegLira exhibits a favorable glycemic control effect and acceptable adverse effects
in Type 2 Diabetes Mellitus (T2DM). Superior performance in the target glycemic control, particularly
suitable for T2DM patients who do not reach the target hemoglobin A1c and have comorbid
CVD or obesity.