University Hospital of South Manchester NHS Foundation Trust (University Hospital of South Manchester NHS Foundation Trust)

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项与 University Hospital of South Manchester NHS Foundation Trust 相关的临床试验

Routine usE of Cerebral Oximetry monitorinG iN cardIac SurgEry. A Randomised Controlled Single Centre Study to evaluate the use of neuromonitoring to identify and reduce postoperative complications

开始日期2018-03-01

申办/合作机构

University Hospital of South Manchester NHS Foundation Trust

ISRCTN16431108 / CompletedN/A

Randomised comparison of two remotely delivered diet and physical activity weight loss programmes vs written diet and physical activity advice amongst overweight women attending a Family History Clinic at increased risk of breast cancer: a phase 3 efficacy study

开始日期2017-11-29

申办/合作机构

University Hospital of South Manchester NHS Foundation Trust

EUCTR2016-003921-40-GB / Not yet recruiting临床2期

Open label study of the efficacy and safety of isavuconazole for the treatment of Chronic Pulmonary Aspergillosis - Isavuconazole for CPA

开始日期2017-07-21

申办/合作机构

University Hospital of South Manchester NHS Foundation Trust

100 项与 University Hospital of South Manchester NHS Foundation Trust 相关的临床结果

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0 项与 University Hospital of South Manchester NHS Foundation Trust 相关的专利（医药）

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941

项与 University Hospital of South Manchester NHS Foundation Trust 相关的文献（医药）

2024-09-01·Journal of Orthodontics

The effectiveness of bone anchored maxillary protraction (BAMP) in the management of class III skeletal malocclusion in children aged 11–14 years compared with an untreated control group: A multicentre two-arm parallel randomised controlled trial

Article

作者: Malik, Ovais ; Bayoumi, Sherif ; Mandall, Nicky ; Aleid, Wesam ; Cousley, Richard ; DiBiase, Andrew ; Waring, David ; Nute, Spencer ; Dyer, Fiona ; Bhatt, Vyomesh ; Goodger, Nicholas ; Bassett, Paul ; Atkins, Simon ; Caldwell, Susi ; Littlewood, Simon ; Chambers, Paul ; Bates, Claire ; Campbell, Sarah Jayne ; Curran, Edith

Objective: To evaluate the effectiveness of bone anchored maxillary protraction (BAMP) in the management of class III skeletal malocclusion in children aged 11–14 years compared with an untreated control group in terms of perceived need for orthognathic surgery, skeletal and dental change, and psychological impact. Design: A multicentre two-armed parallel randomised controlled trial. Setting: Six UK hospital orthodontic units. Methods: A total of 57 patients were randomly allocated into either the BAMP group (BAMPG) (n = 28) or a no treatment control group (CG) (n = 29). Outcomes: Data collection occurred at registration (DC1),18 months (DC2) and 3 years (DC3), where skeletal and dental changes were measured from lateral cephalograms and study models. Oral Aesthetic Subjective Impact Score (OASIS) and Oral Quality of Life (OHQOL) questionnaires were used to assess the psychological impact of treatment. Results: The mean age was 12.9 ± 0.7 years and 12.6 ± 0.9 years in the BAMPG and CG, respectively. At DC2, the BAMPG achieved a class III ANB improvement of +0.6° compared with −0.7° in the CG ( P = 0.004). The overjet improvement was +1.4 mm for the BAMPG and −0.2 mm for the CG ( P = 0.002). There was no evidence of any other group differences for the other skeletal or dental cephalometric outcomes ( P > 0.05) or the questionnaire data (OASIS P = 0.10, OHQOL P = 0.75). At DC2, the 18-month follow-up, 22% of the BAMPG achieved a positive overjet. At the 3-year follow-up (DC3), fewer participants in the BAMPG were perceived to need orthognathic surgery (48%) compared with 75% of participants in the CG ( P = 0.04), with an odds ratio of 0.31 (95% confidence interval = 0.10–0.95). Conclusion: The BAMP technique did not show any social or psychological benefits; however, the skeletal class III improvement in ANB and the overjet change were sufficient to reduce the perceived need for orthognathic surgery by 27% compared with the CG.

2024-05-01·A46. DIAGNOSIS AND MONITORING OF ILD

Impact of Instilled Saline Volume on Adequate Bronchoalveolar Lavage Sample in Interstitial Lung Disease Diagnosis

作者: Yioe, V. ; Bowes, K.S.P. ; Johnston, J. ; Montero, A. ; Callum, J. ; Stanel, S. ; Greaves, M. ; Rivera Ortega, P. ; Hayton, C.

2024-03-25·Materials Testing

Pull-out strength of screws in long bones at different insertion angles: finite element analysis and experimental investigations

作者: Shoaib, Amer ; Gepek, Engin ; Bayam, Levent ; İyibilgin, Osman ; Drampalos, Efstathios

AbstractDifferent types of plates are available to allow insertion of screws for internal fixation of long bone fractures. The aim of the study was to determine the effect of the insertion of screws at different angles on a long bone to the pull-out strength. Using 3D printed bone models, we tested the pull-out strength of screws in long bones at insertion angles between 0 and 40° with both finite element analysis and on printed models experimentally and compared the results. Test samples and cortical screws used were modeled with SolidWorks software and analyzed with Ansys software. As the screw insertion angle increases, the pull-out forces on the test specimens increase from 61.14 ± 3.5 N at 0° to 273 ± 6.8 N at 40° with an exception of a small drop between 15 and 20° from 235.4 ± 6.2 to 233 ± 6.9 N. Both methods showed an increase in the pull-out strength of screws as the insertion angle increases. This might be applicable in the clinical practice of bone fixation. Further studies on plate and screw fixation are needed to complement the findings.

100 项与 University Hospital of South Manchester NHS Foundation Trust 相关的药物交易

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100 项与 University Hospital of South Manchester NHS Foundation Trust 相关的转化医学

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