A review.This article elucidates how mutagenesis was employed to make an anti-methicillin-resistant Staphylococcus aureus (MRSA) drug.The com. applications of pathways engineering are discussed.The growth in antibiotic resistance has promoted an urgent need for new antibacterial agents of genuinely new classes.The study of pathogen genomes has yielded a wealth of new target information.Thus, pathway engineering is definitely important in the development of promising natural lead structures into new therapeutic agents.