Sociedade Potiguar de Educacão e Cultura Ltda. (Sociedade Potiguar de Educacão e Cultura Ltda.)

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5

项与 Sociedade Potiguar de Educacão e Cultura Ltda. 相关的临床试验

NCT02445716

/ Unknown status临床2期IIT

Transdermal Testosterone Nanoemulsion Effects Emergent Loss of Libido in Women: A Randomized, Double-Blind, Placebo-Controlled Trial

This is a double-blind, randomized, placebo-controlled study. Seventy women, aged 35-75 years, with treatment-emergent loss of libido will be randomly allocated to the treatment with a Transdermal nanoemulsion of Testosterone (500mcg) delivering 300 mcg of testosterone/day or an identical placebo nanoemulsion (PLA) for 12 weeks.

开始日期2015-10-01

申办/合作机构

Sociedade Potiguar de Educacão e Cultura Ltda.

[+2]

NCT02582892

/ Completed临床4期IIT

Systemic Vitamin D Supplementation in Menopausal Women With Dental Implants

Vitamin D plays an essential role in calcium homeostasis and is critical for bone formation and remodeling.

开始日期2012-10-01

申办/合作机构

Sociedade Potiguar de Educacão e Cultura Ltda.

NCT02467673

/ Completed临床2期IIT

Nanoparticulate Versus Micronized Steroids Delivery for Transdermal Hormone Replacement Therapy: Effects on Blood Pressure, Insulin and C-reactive Protein and in Postmenopausal Women

The study aims to asses the effects of micronized (MIC) and nanoparticulate (NANO) transdermal hormone therapy (THT) on blood pressure, ultra-sensitive C-reactive protein (CRP), and cardiovascular risk factors in postmenopausal women.

开始日期2012-01-01

申办/合作机构

Sociedade Potiguar de Educacão e Cultura Ltda.

[+2]

100 项与 Sociedade Potiguar de Educacão e Cultura Ltda. 相关的临床结果

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0 项与 Sociedade Potiguar de Educacão e Cultura Ltda. 相关的专利（医药）

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1,101

项与 Sociedade Potiguar de Educacão e Cultura Ltda. 相关的文献（医药）

2025-01-02·Women & Health

Magnesium sulfate versus nifedipine for tocolysis: meta-analysis of randomized controlled trials

Review

作者: de Souza, Amaxsell Thiago Barros ; de Lima Machado, Maria Letícia ; Costa, Ana Paula Ferreira ; Costa, Tatiana Xavier da ; de Medeiros, Kleyton Santos ; Cobucci, Ricardo Ney ; Sarmento, Ayane Cristine Alves ; Martins, Rand Randall ; Vale, Adson José Martins

Preterm labor, defined as contractions occurring every 5-10 minutes with cervical changes before the 37th week of estimated gestation, is a significant cause of perinatal mortality. This meta-analysis aims to evaluate the effectiveness and safety of magnesium sulfate compared to nifedipine in managing preterm labor. The systematic review protocol was registered with PROSPERO (CRD42023422419). Manuscripts published up to September 2024 were systematically searched in databases. Dichotomous data were pooled as odds ratios using a random-effects model with the Mantel-Haenszel method, while continuous data were analyzed as mean ± standard deviation values, mean differences, and standardized mean differences using inverse-variance fixed-effects analysis. Fifteen randomized clinical trials (RCTs) were included, enrolling a total of 2,186 pregnant women. Nifedipine showed a greater effect compared to a 4-gram IV dose of magnesium sulfate. However, the efficacy of these tocolytics in prolonging pregnancy by 48 hours did not significantly differ between nifedipine and a 6-gram IV dose of magnesium sulfate. Additionally, magnesium sulfate was associated with more adverse drug reactions. The moderate certainty of evidence found here requires confirmation in large, adequately powered RCTs.

2025-01-01·American Journal of Obstetrics & Gynecology MFM

Reply to “Letter to Editor Regarding The Role of Pravastatin in Preventing Preeclampsia in High-Risk Pregnant Women: A Meta-Analysis With Trial Sequential Analysis”

Letter

作者: Provinciatto, Henrique ; Barbalho, Maria Esther

2024-12-01·Recent Patents on Nanotechnology

Croton cajucara: Patents and Nanotechnological Advances

Review

作者: da Silva Júnior, Francisco Lopes ; Medeiros Maciel, Maria Aparecida ; Lima, Laís Rocha ; Arcanjo, Daniel Dias Rufino

Abstract:Croton cajucara Benth showed several pharmacological properties such as: antiinflammatory, antinociceptive hypoglycemic, lipid-lowering, antiulcer, antiestrogenic, antitumor, antigenotoxic, antimutagenic, and cardiovascular. The 19-nor-clerodane diterpene transdehydrocrotonin (t-DCTN or DCTN) is the major bioactive constituent extracted from the bark of this Croton. Patents for Croton cajucara Benth in the period 2015 to 2022 comprises 14 published documents. Among them 4 patents are colloidal systems (SM/SNEDDS) loading t-DCTN for pharmacological applications. Patent registrations highlighted the huge promising biotechnological potential of Croton cajucara Benth especially in the phytotherapy field, and the correlation with its bioactive constituents of which t-DCTN showed the foremost results, so this herbal could become an alternative in the treatment of COVID-19. However, investigation of more recently published patents for clerodane diterpenes with similar chemical structure of t-DCTN, who previously showed antiviral property must be carried out and should be searched on several patent data bases.

100 项与 Sociedade Potiguar de Educacão e Cultura Ltda. 相关的药物交易

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100 项与 Sociedade Potiguar de Educacão e Cultura Ltda. 相关的转化医学

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