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项与 HLB Cell Co., Ltd. 相关的临床试验

KCT0007653 / RecruitingN/A

A Multicenter, Single-blind, Randomized, Active-controlled, Non-inferiority, Pivotal Study to Evaluate the Safety and Efficacy of HLBLS-200 in Patients Requiring Hemostatic Treatment for Oozing Hemorrhage following Primary Hemostatic Treatment (Suture, Ligature, Vascular Clip, Argon Beam Coagulation, Electrocautery, etc.) during Liver Resection

开始日期2022-07-07

申办/合作机构

HLB Cell Co., Ltd.

KCT0003619 / Withdrawn临床2期

A prospective, open-label study of the safety and efficacy of Hepastem infusion in pediatric patients with urea cycle disorders.

开始日期2020-10-01

申办/合作机构

HLB Cell Co., Ltd.

KCT0003748 / Recruiting临床2期

A Phase 2b study to evaluate safety and efficacy of Lifeliver(Bio Artificaial Liver) in acute or acute-on-chronic liver failure patients waiting emergent liver transplantation.

开始日期2019-10-12

申办/合作机构

HLB Cell Co., Ltd.

100 项与 HLB Cell Co., Ltd. 相关的临床结果

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0 项与 HLB Cell Co., Ltd. 相关的专利（医药）

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12

项与 HLB Cell Co., Ltd. 相关的文献（医药）

2019-11-01·Anticancer Research4区 · 医学

Effect of Tissue Transglutaminase on Steroid Resistance in T-Cell Acute Lymphoblastic Leukemia

4区 · 医学

Article

作者: Yoon, Seung-Hyun ; Han, Eun Hee ; Jung, Hyun Joo ; Jang, In Keun ; Park, Jun Eun

AIMTo improve survival in patients with glucocorticoid-resistant T-cell acute lymphoblastic leukemia (T-ALL), it is critical to develop new therapeutic strategies to overcome steroid resistance.MATERIALS AND METHODSBiochemical and molecular methodologies were used to evaluate whether tissue transglutaminase (TG2) confers steroid resistance in T-ALL.RESULTST-ALL cells were found to express elevated levels of TG2. Models of steroid-adapted subclones of T-ALL cell lines which were notably less sensitive to steroids than the parental cells. The steroid-adapted subclones showed increased TG2 expression and nuclear factor-κB (NF-κB) activity compared to T-ALL parental cells. Inhibition of TG2 suppressed steroid resistance and improved steroid cytotoxicity in steroid-adapted subclones of T-ALL in association with reduced NF-κB activity.CONCLUSIONTG2 may serve as a new target to overcome steroid resistance in T-ALL.

2018-04-01·Stem Cell Reviews and Reports3区 · 医学

Involvement of TLR3-Dependent PGES Expression in Immunosuppression by Human Bone Marrow Mesenchymal Stem Cells

3区 · 医学

Article

作者: Yoo, Keon Hee ; Lee, Whi Hyeong ; Lee, Ji Won ; Kim, Dae Seong ; Lee, Myoung Woo ; Sung, Ki Woong ; Park, Hyun Jin ; Jang, In Keun ; Koo, Hong Hoe

Human mesenchymal stem cells (MSCs) are known for their prostaglandin E₂ (PGE₂)-mediated immunosuppressive function but the precise molecular mechanisms underlying PGE₂ biosynthesis during inflammation have not been completely elucidated. In this study, we have investigated the involvement of PGE₂ pathway members in PGE₂ production by bone marrow (BM)-MSCs in response to inflammatory stimuli, and their role in immunosuppression mediated by BM-MSCs. We found that IFN-γ and TNF-α increased cyclooxygenase (COX)-2 expression but not that of prostaglandin E synthase (PGES), or PGE₂ production. On the other hand, the toll like receptor 3 (TLR3) stimulant poly(I:C) increased expression of both COX-2 and PGES, resulting in a significant increase in PGE₂ levels. This effect was reversed upon COX-2 inhibition with indomethacin or PGES downregulation by siRNA. Reduced PGE₂ levels decreased MSC's capacity to inhibit hPBMC proliferation. In addition, administration of MSCs with inhibited PGES expression into mice with graft-versus-host disease (GVHD) did not reduce mortality. In summary, the present study reveals that upregulation of PGES via TLR3 is critical for BM-MSCs-mediated immunosuppression by PGE₂ secretion via the COX-2/PGE₂ pathway. These results provide a basis for understanding the molecular mechanisms underlying the PGE₂-mediated immunosuppressive properties of MSCs.

2015-04-01·Transplantation Proceedings4区 · 医学

Suppression of T-Cell Proliferation by and B7-H1 Expression on Human Liver-Derived Stem Cells

4区 · 医学

Article

作者: Kim, Y A ; Lee, S H ; Park, H J ; Jang, I K ; Lee, J H ; Lee, S-K ; Yoon, H H ; Lee, D H

BACKGROUNDMany types of stem cells have been widely used for the treatment of liver diseases. The therapeutic effect of stem cells is predominantly based on the immune regulatory properties of these cells.METHODSWe isolated human liver stem cells (HLSCs), which are considered intrahepatic stem cells, and examined their suppression of T-cell proliferation induced by phytohemagglutinin.RESULTSHLSCs inhibited phytohemagglutinin-induced T-cell proliferation not only in direct co-culture but also in indirect co-culture in a cell number-dependent manner. That is, T-cell proliferation was substantially inhibited by cell-to-cell contact regardless of soluble factor(s). B7-H1, a co-inhibitory molecule that relies on cell-to-cell contact, was found to be constitutively expressed at low levels on HLSCs. Furthermore, its expression was upregulated moderately by tumor necrosis factor-α and dramatically by interferon-γ.CONCLUSIONSThese results suggest that HLSCs would have therapeutic effects through T-cell suppression in acute liver diseases.

100 项与 HLB Cell Co., Ltd. 相关的药物交易

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100 项与 HLB Cell Co., Ltd. 相关的转化医学

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