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2

项与 Hokuriku University Educational Association 相关的药物

KIL-769

靶点

Kv7.2

作用机制

Kv7.2激动剂

在研机构-

原研机构

Hokuriku University Educational Association

在研适应症-

非在研适应症

排尿障碍

最高研发阶段无进展

首次获批国家/地区-

首次获批日期-

XT-44

靶点

PDE4 x calcium channel

作用机制

PDE4抑制剂 [+1]

在研机构-

原研机构

Hokuriku University Educational Association

在研适应症-

非在研适应症

心脏衰竭

最高研发阶段无进展

首次获批国家/地区-

首次获批日期-

7

项与 Hokuriku University Educational Association 相关的临床试验

JPRN-UMIN000054489 / Recruiting

Factors Predicting Clinical Outcomes in Older Adults Requiring Support and Care - Factors Predicting Clinical Outcomes in Older Adults Requiring Support and Care

开始日期2024-06-01

申办/合作机构

Hokuriku University Educational Association

[+1]

JPRN-UMIN000051811 / Completed

Verification of the effect of training with whole-body vibration on lumbar motor control. - Effects of whole-body vibration training on lumbar motor control

开始日期2023-09-26

申办/合作机构

Hokuriku University Educational Association

[+1]

JPRN-UMIN000053503 / Completed

Immediate effects of lower extremity coordination training using a leg press device on ankle motor control in individuals with chronic ankle instability - Immediate Effects of coordination training with leg press on ankle movements

开始日期2023-09-13

申办/合作机构

Hokuriku University Educational Association

100 项与 Hokuriku University Educational Association 相关的临床结果

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0 项与 Hokuriku University Educational Association 相关的专利（医药）

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1,923

项与 Hokuriku University Educational Association 相关的文献（医药）

2024-01-02·Language Acquisition

Acquisition of overt and covert and : support for the semantic subset principle

作者: Fujiwara, Yoshiki ; Shimada, Hiroyuki

2022-12-01·Journal of Shoulder and Elbow Surgery

The relationship between scapular position and glenohumeral rotational range of motion in high school baseball players

Article

作者: Kanazawa, Yuji ; Higuchi, Takashi ; Tanaka, Yasuaki ; Matsuo, Moemi ; Yokoyama, Shigeki

BACKGROUNDPast research indicated that scapular malposition is related to the glenohumeral internal rotation deficit (GIRD). However, there is no research examining the effect of throwing-related pain on this relationship. This study investigated the relationship between scapular position and range of motion (ROM) and compared the difference in this relationship between with and without throwing-related pain.METHODSForty male baseball players in high school were recruited for this study. The existence and degree of throwing-related pain were obtained from a questionnaire. Participants were divided into 2 groups according to the presence or absence of the pain. Glenohumeral internal and external rotation ROM (abduction internal rotation angle and abduction external rotation angle [ABER], respectively) were measured using a digital inclinometer. The pectoralis minor muscle length was measured using a vernier caliper and scapula index, which indicated the scapular position, measured using a measuring tape. All these measurements were taken on both dominant and nondominant sides. The GIRD and total motion arc (TMA) deficit were calculated from the ROM measurements. Groups were compared using a mixed-model analysis of variance.RESULTSThere was a significant interaction between group and ABER dominance. Other variables were not seen as the interaction effect. There was a significant positive correlation between the scapula index and TMA (r = 0.47, P = .02) and a negative correlation between the scapula index and GIRD (r = -0.65, P < .01) in the dominant side of the pain group. In addition, in the nondominant side of the pain group, the scapula index and ABER were significantly correlated (r = 0.43, P = .04).CONCLUSIONSThe results of this study indicate that the scapular position is associated with the glenohumeral ROM in high school baseball players. In addition, this study demonstrated that the scapular internally rotated position was correlated with the GIRD and TMA deficit in high school baseball players who had throwing-related pain. On the other hand, the scapular externally rotated position was correlated with increased ABER, mainly in the pain-free baseball players or on the nondominant side. These results indicated that the scapular position might affect the glenohumeral rotational ROM in high school baseball players.

2022-07-01·Pharmacology & Therapeutics1区 · 医学

Antiviral therapy for COVID-19: Derivation of optimal strategy based on past antiviral and favipiravir experiences

1区 · 医学

Review

作者: Sakai, Kaoru ; Shiraki, Kimiyasu ; Takemoto, Masaya ; Kaszynski, Richard H ; Matsumoto, Shirou ; Sato, Noriaki

Favipiravir, a broad-spectrum RNA-dependent RNA polymerase inhibitor, inhibits the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at significantly lower concentrations than the plasma trough levels achieved by the dosage adopted for influenza treatment and exhibits efficacy against coronavirus disease 2019 (COVID-19) pneumonia. Although high doses of favipiravir are required due to the molecule being a purine analog, its conversion into the active form in infected cells with active viral RNA synthesis enhances the antiviral specificity and selectivity as a chain terminator with lethal mutagenesis. Another characteristic feature is the lack of generation of favipiravir-resistant virus. COVID-19 pneumonia is caused by strong cell-mediated immunity against virus-infected cells, and the inflammatory response induced by adaptive immunity continues to peak for 3 to 5 days despite antiviral treatment. This has also been observed in herpes zoster (HZ) and cytomegalovirus (CMV) pneumonia. Inflammation due to an immune response may mask the effectiveness of favipiravir against COVID-19 pneumonia. Favipiravir significantly shortened the recovery time in patients with mild COVID-19 pneumonia by 3 days with the start of treatment by the 5th day of symptom onset. Since both CMV and COVID-19 pneumonia are caused by adaptive immunity and prevention of cytomegalovirus pneumonia is the standard treatment due to difficulties in treating refractory CMV pneumonia, COVID-19 pneumonia should be prevented with early treatment as well. In the present study, we have comprehensively reviewed the optimal antiviral therapy for COVID-19 based on clinical trials of favipiravir for the treatment of COVID-19 pneumonia and the concurrently established therapies for other viral infections, particularly HZ and CMV pneumonia. Optimally, antivirals should be administered immediately after COVID-19 diagnosis, similar to that after influenza diagnosis, to prevent COVID-19 pneumonia and complications resulting from microangiopathy.

100 项与 Hokuriku University Educational Association 相关的药物交易

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100 项与 Hokuriku University Educational Association 相关的转化医学

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