Delving into the Latest Updates on Pharos University in Alexandria with Synapse

概览

疾病领域	数量

神经系统疾病	1

排名前五的药物类型	数量

小分子化药	1

排名前五的靶点	数量

JNK x mTOR	1

关联

1

项与 Pharos University in Alexandria 相关的药物

Morin hydrate

靶点

JNK x mTOR

作用机制

JNK抑制剂 [+1]

在研机构

Pharos University in Alexandria

原研机构-

在研适应症

亨廷顿舞蹈病

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

9

项与 Pharos University in Alexandria 相关的临床试验

NCT06511336 / Active, not recruiting临床3期IIT

Evaluation of Alkaline Water Effect on Salivary Streptococcus Mutans in Children

This study will be aimed to examine the effect of alkaline water on salivary streptococcus mutans bacteria which is the main cause of dental caries and comparing its effect with chlorohexidine mouthwash on the children aged 10-12. tap water will be used as mouthwash for negative control group.

开始日期2024-07-01

申办/合作机构

Pharos University in Alexandria

NCT06266481 / Recruiting临床2/3期IIT

Topical Dexamethasone Versus Topical Lidocaine Spray to Reduce Post-intubation Sore Throat in Shoulder Arthroscopic Surgeries: A Comparative Study

postoperative sore throat is the most frequent side effects after anaesthesia intubation. Dexamethasone and 10% lidocaine spray used prior to surgery has shown useful in managing these complications at the moment. In order to examine the prophylactic impact of local Dexamethasone and lidocaine on postoperative sore throat, this study was conducted.

开始日期2024-03-01

申办/合作机构

Pharos University in Alexandria

NCT06203535 / Not yet recruitingN/AIIT

Effect of Aerobic Training on Quality of Life in Elderly With Idiopathic Chronic Fatigue

the study was conducted to evaluate the effectiveness of aerobic training for decreasing fatigue severity and increasing quality of life in elderly with idiopathic chronic

开始日期2024-02-10

申办/合作机构

Pharos University in Alexandria

100 项与 Pharos University in Alexandria 相关的临床结果

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0 项与 Pharos University in Alexandria 相关的专利（医药）

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995

项与 Pharos University in Alexandria 相关的文献（医药）

2024-06-01·Sleep and Breathing

Recommendations for future research on sleep paralysis

Letter

作者: Elfakharany, Bahaa ; Amer, Samar Ahmed ; Elsayed, Mohamed E G ; Amer, Basma Ehab ; Mouffokes, Adel ; Khlidj, Yehya ; Moghib, Khaled ; Soni, Nishant Parag ; Alazzeh, Zainab Jamal ; Hefnawy, Mahmoud Tarek

2024-06-01·International Journal of Pharmaceutics: X

Non-invasive caffeinated-nanovesicles as adipocytes-targeted therapy for cellulite and localized fats

Article

作者: Elnaggar, Yosra S R ; Abdelkader, Hamdy ; Abdallah, Ossama Y ; El-Refaie, Wessam M ; Khalil, Lobna M ; Al Fatease, Adel

Caffeine (CAF) is a non-selective adenosine A1 receptor antagonist which predominates in fat cells. When CAF binds to adenosine receptors, it increases cyclic adenosine monophosphate; inhibiting adipogenesis and inducing fat lipolysis. Resveratrol (RSV) is an antioxidant polyphenol possessing different anti-obesity mechanisms. Topical application of both hydrophilic CAF and lipophilic RSV is limited. This study aimed to develop novel caffeinated-resveratrol bilosomes (CRB) and caffeine-bilosomes (CB) that could non-invasively target and deposit in fat cells. RSV bilosomes (RB) were prepared as a non-targeted system for comparison. CRB showed nanosize (364.1 nm ±6.5 nm) and high entrapment for both active compounds. Rats treated topically with CRB revealed a significant decrease (P = 0.039) in body weight. Histological analysis of the excised skin demonstrated a reduction in the subcutaneous fatty layer thickness and a decrease in the size of connective tissue-imbedded fat cells. Kidney histological examination of RB-treated rats showed subcapsular tubular epithelial cells with cytoplasmic vacuolation. This reflects a systemic effect of RSV from the non-targeted RB compared to CRB, which had a targeting effect on the adipose tissue. In conclusion, CAF in CRB significantly enhanced RSV deposition in adipose tissue and assisted its local-acting effect for managing obesity and cellulite.

2024-05-01·Journal of Drug Delivery Science and Technology

Development and characterization of plant derived wastes Nano-formulation loaded in thermo-reversible gel for burn healing: An effort towards Sustainable Development

作者: Awwad, Zeinab M. ; Abou-Taleb, Basant A. ; Ali, Dalia E. ; Mahmoud, Shimaa A. ; Bassam, Samar M.

The duty of research is to suggest solutions to ailments affecting humans.Recently, there has been a demand that these solutions should be environmentally responsible, eco-friendly and coincide with sustainable development goals.From this perspective, the objective of this study was to develop thermo-reversible and healing promoting gel formulations.The gel base incorporated Natural Plant derived Wastes′ ethanolic extracts of either Kiwi peels (KE) or Yucca seeds (YE) (antioxidant, vitamins and anti-inflammatory natural agent) loaded chitosan nanoparticles for enhancement of burn healing performance.Comparative evaluation was done to all formulations to find the best competitor to conventional marketed drug formulations.Both extracts were standardized using HPLC.The lipoid content of YE was investigated using GC-MS, showing a content of 32.78 and 15.7 %of linoleic and pamiticmethyl esters, resp.The nanoparticles characterization and the in-vitro physicochem. characteristics of the final dosage form formulations were assessed, revealing86.65 and 76.6 % entrapment efficiency, 311.4 and 198.1 nm particle size for KE and YE nanoformulations, resp.The efficacy of the formulations was investigated in vivo against the com. burn healing drug Mebo, biochem. parameters and histopathol. were statistically investigated.Reduction in wound area reached 69.12 and 72.01 % on day 12 for KE and YE nanoformulations, resp.The YE encapsulated within chitosan nanoparticles loaded gel showed a promising and a significant healing effect comparable to the most commonly used marketed drug product (Mebo) and possible mechanisms involved in the phases of healing were illustrated.Eco-friendly waste herbal extracts-loaded chitosan nanoparticles in thermo-reversible gel have been successfully developed from the two extracts: Kiwi peels and yucca seeds for burn and wound healing.This confirms the possible use of traditional medicines in advanced formulations to satisfy the future market of pharmaceuticals.

100 项与 Pharos University in Alexandria 相关的药物交易

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100 项与 Pharos University in Alexandria 相关的转化医学

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