Asian University For Women

This article identifies the first known instance of visual engagement with the iconic anatomical imagery of Andreas Vesalius' De humani corporis fabrica (1543) east of Istanbul. Two skeleton men from the Fabrica provide the design for skeletal sculptures decorating the Dutch cemetery in the colonial port town of Pulicat, in Tamil Nadu, India. We ask what it meant to engage with these iconic images of European anatomy in a seventeenth-century trading port on the Bay of Bengal, both for those who were responsible for their production and for those who passed by the cemetery. This article argues that the visual solutions of the Pulicat sculptures bring into conversation not only medical anatomy and funerary architecture, but also the artistic traditions of Europe and the Deccan, and, most importantly, the somewhat differing early modern European and Indian approaches to visualizing the skeletal structures of human bodies. The Pulicat sculptures can be productively understood as a potential meeting point for the contemplation of the fragile human body from the perspectives of European and Islamicate anatomy, Christian traditions of natural theology and memento mori, as well as South Indian and especially mystic Sufi asceticism.

Kidney Renal Clear Cell Carcinoma (KIRC) is a leading cause of cancer death worldwide, but its early detection remains hindered by a lack of genetic markers. Our study aims to find prospective biomarkers that could serve as prognostic indicators and help in the identification of efficient drug candidates for KIRC treatment. Importantly, this study identifies the hub genes that play a crucial role in KIRC and their impact on male and female patients. The cBioPortal was used to identify frequently mutated genes across seven KIRC studies. Additionally, GSE168845 was employed to identify the differentially expressed genes. The analysis revealed that the titin (TTN) gene was mutated and upregulated in KIRC. Subsequently, differential genes of wild-type TTN versus mutant TTN were identified using TNMplot. The NetworkAnalyst tool was used to conduct KEGG analysis and PPI analysis on these genes. Furthermore, the Kaplan-Meier Plotter was utilized to perform overall survival analysis. Our findings indicated that the TTN gene leads to poorer prognosis in women than in men. We also discovered that the female-specific prolactin signaling pathway plays a significant role in the progression of KIRC. Moreover, our study suggested that the GDF15 gene, involved in the prolactin signaling pathway, has a worse prognosis for KIRC in women than in men. Additionally, mRNA expression analysis showed a negative correlation between GDF15 and MAPK14 in KIRC. Collectively, our research indicates that TTN, GDF15, and MAPK14 can serve as prognostic biomarkers in female KIRC patients, offering prospects for enhanced treatment and patient outcomes in these cancers.

Bangladesh is a well-known epidemic zone for dengue fever. Several epidemiological and geographical factors influence the transmission and severity of dengue infection. This study aimed to determine the epidemiological and geographical factors that contributed to the severity of the dengue outbreak in Bangladesh in 2023. This hospital-based cross-sectional study investigated 1,313 dengue patients admitted to public hospitals in Dhaka, Chattogram and Kishoreganj, Bangladesh, between July and December 2023. Multiple logistic regression analyses were conducted to identify the independent risk factors for severe dengue infection. The average age of respondents was 29.5 years, with individuals aged 20–40 accounting for 59.5%. Of the 1,313 dengue patients, 19.3% (254) were diagnosed with severe dengue infection. Patients with low monthly income and those lacking awareness of dengue’s spread from clogged rooftop water were respectively 2.35 (adjusted odds ratio [aOR] 2.35; P <0.05; 95% CI: 1.08–5.07) and 2.23 (aOR 2.23; P <0.05; 95% CI: 1.20–4.14) times more likely to develop severe dengue. The dengue outbreak has become a serious public health issue in Bangladesh, with factors such as low family income and lack of awareness contributing to the development of severe cases. These findings provide valuable evidence for policymakers to guide and implement preventive measures and raise awareness.