Effectiveness of Ayurveda-Based lifestyle Advocacies and Practices on Quality of Life among Children of Ekalavya Model Residential Schools in India - NIL

开始日期2024-10-21

申办/合作机构

Central Council For Research In Ayurvedic Sciences

100 项与 Central Council For Research In Ayurvedic Sciences 相关的临床结果

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109

项与 Central Council For Research In Ayurvedic Sciences 相关的文献（医药）

2025-01-01·Journal of Ethnopharmacology

Evaluation of Anti-arthritic and in-vitro Anti-inflammatory activity of Vaisvanara Churna

Article

作者: Gaidhani, Sudesh N ; Thenmozhi, M. ; Thenmozhi, M ; Ilavarasan, R ; Manikandan, N. ; Gaidhani, Sudesh N. ; Arunadevi, R. ; Kusuma, G ; Manikandan, N ; Ilavarasan, R. ; Kusuma, G. ; Arunadevi, R

ETHNOPHARMACOLOGICAL RELEVANCEVaisvanara Churna used traditionally for the treatment of Amavata (Rheumatoid arthritis), Shotaprasamana (Anti-inflammatory) and as Saraka (Laxative).AIMAim of the study is to evaluate anti arthritic activity and in vitro anti-inflammatory potential of Vaisvanara Churna in experimental animals.MATERIALS AND METHODSIn-vitro anti-inflammatory activity of aqueous extract of Vaisvanara Churna (100-500 μg/ml) was evaluated by using membrane stabilization methods. Anti arthritic activity was evaluated by using 0.1 ml of Complete Freund's Adjuvant (CFA) injected into sub plantar surface of left hind paw of each wistar rat on day 1 followed by treatment with Vaisvanara Churna at various dose levels (450, 900, and 1800 mg/kg b.w) and standard drug Prednisolone (5 mg/kg) for 21 days. The following parameters namely change in the body weight of animals, paw volume, ankle joint thickness were measured at 0, 3, 8, 17 & 21 day intervals and radiographic changes were assessed. In addition to this, response to painful stimuli by application of forced pressure was measured by using Pressure Application Measurement (PAM) method.RESULTSIn-vitro anti-inflammatory activity Vaisvanara Churna exhibited dose dependent membrane stabilizing activity. Treatment with Vaisvanara Churna showed significant (p < 0.05) inhibition of paw edema, reduction in ankle joint thickness and increase in the body weight of wistar albino rats was observed. There is a significant increase (p < 0.001) in the latency of limb withdrawal response, reduction in the organ indices (spleen and thymus) were noted.CONCLUSIONThis study demonstrates that Vaisvanara Churna possesses in vitro anti inflammatory and anti-arthritic potential and supports its folklore use in the treatment of arthritis.

2024-11-01·Microbial Pathogenesis

Immune and microbiome modulatory effects of Limosilactobacillus fermentum NCDC 400 in an immunocompromised mouse model

Article

作者: Nagpal, Ravinder ; Behare, Pradip V ; Nataraj, Basavaprabhu Haranahalli ; Ranveer, Soniya A ; K, Jeevan

The present study was aimed to assess and validate the safety and functional efficacy of an indigenous probiotic strain Limosilactobacillus fermentum NCDC 400 (hereafter, LFN400) in an immunocompromised murine model. The study included four groups; a normal control (NC) group without immune suppression; an experimental model control (MC) with immune suppression induced via intraperitoneal cyclophosphamide (Cy) administration; and two MC groups orally administered with either low dose (LD) or high dose (HD) of LFN400 at dose 10⁸ and 10¹⁰ CFU/mouse/day, respectively, for 15-days. Both control groups received normal saline as placebo control. LFN400 improved specific experimental characteristics including hematological and serum biochemical markers. Compared to MC group, LFN400-fed groups showed markedly (P < 0.05) decreased arrays of detrimental caecal enzymes. We did not observe instances of bacterial translocation of LFN400 from gut to bloodstream or extra-intestinal organs. LFN400 intake significantly (P < 0.05) enhanced spleen cell differentiation, immune and oxidative stress markers, and restored Cy-induced histopathological changes in multiple tissues, including the spleen. There was no genotoxic effect of LFN400 on bone marrow cells. Although not statistically significant, LFN400 feeding moderately increased gut microbiome diversity, supporting the growth of beneficial saccharolytic microorganisms and reducing the presence of pathobionts. The findings demonstrate that the probiotic strain LFN400 possesses in vivo safety and immunomodulatory potency and thus should be considered a potential candidate for future human clinical studies.

2024-09-01·Current Biotechnology

Development of Quality Standard and a Comprehensive Quality Control Study of Bharngyadi Kvatha Churna: An Ayurvedic Formulation

作者: Babu, Gajji ; Kumar, Vijay ; Narasimhaji, Cheemalapati Venkata ; Ghosh, Debomitha ; Ghandi, Yashika ; Bolleddu, Rajesh ; Singh, Ravindra ; Das, Manosi ; Acharya, Rabinarayan ; Dighe, Dattatray ; Marimuthhu, Gokul ; Das, Debajyoti ; Kurra, Siva Durga ; Srikanth, Narayanam ; Rao, Meda M.

Background:Bharngyadi Kvatha Churna (BKC) is an important polyherbal formulation mentioned in the Ayurvedic Formulary of India (AFI) for the treatment of intermittent fever and chronic fever but lacks the presence of standardised quality control parameters.Aims:The aim of the present study was to develop a quality standard of BKC and to carry out a comprehensive quality control study, including the evaluation of physicochemical parameters, safety parameters, elemental content, secondary metabolites, and selected phytochemical analysis.Methods:In HPTLC analysis, piperlongumine was quantified in BKC using a silica gel-coated aluminium plate and developing solvent of toluene: acetone (6:4 v/v). In HPLC analysis, piperine was quantified using acetonitrile: water (80: 20 v/v) mobile phase, and ellagic acid was quantified using water (0.05% KH2PO4): acetonitrile (70: 30 v/v) mobile phase. ICP-OES was used to determine elemental content. The estimation of secondary metabolites like total sugars, tannins, flavonoids, alkaloids, and saponins was also carried out using a UV-Vis spectrophotometer. The volatiles present in the volatile oil of BKC were analysed using the gas chromatography-mass spectrometry technique.Results:The physicochemical parameters namely, loss on drying, total ash, acid-insoluble ash, alcohol- soluble extractive, water-soluble extractive, pH (10% aq. susp.), and volatile oil ranged from 10.56% to 11.06%, 4.67% to 5.76%, 0.73% to 1.78%, 7.56% to 8.2%, 12.04% to 13.06%, 5.87% to 5.96%, and 0.091% to 0.097%, respectively. The amount of piperlongumine in BKC ranged from 0.7688 mg/g to 0.9902 mg/g. The amount of piperine and ellagic acid ranged from 0.1180% to 0.1362% and 0.0016% to 0.0034%, respectively. Oleyl alcohol is the major volatile phytochemical present in BKC.Conclusions:The developed standardised quality control parameters of BKC would aid the herbal industry in developing BKC with requisite quality.

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