Elios Therapeutics LLC

Dr. Corrigan brings over three decades of life sciences leadership experience to Silver Creek. SAN FRANCISCO, Feb. 12, 2024 /PRNewswire/ -- Silver Creek Pharmaceuticals, a clinical-stage biotechnology company focused on the selective targeting of naturally-occurring growth factors to promote cell survival and growth, has appointed Mark Corrigan, MD, as President. Continue Reading (PRNewsfoto/SILVER CREEK PHARMACEUTICALS) "We are pleased to welcome Dr. Corrigan to lead Silver Creek through its next phase of growth," said Tim Throsby, Silver Creek's Chairman of the Board. "We are confident that Mark's deep experience in drug development and life sciences leadership will enable the company to continue to advance scp776 and our Smart Growth Factor™ platform, bringing us one step closer to achieving our mission of changing lives by rescuing cells from injury." "The elegance and innovation behind Silver Creek's Smart Growth Factor™ platform is very compelling, and the pre-clinical data around scp776 is equally impressive. I am excited to join the team at a time when the ARPEGGIO study is gaining momentum, and to help guide the organization through this much-anticipated data read-out," said Dr. Corrigan. Dr. Corrigan is an industry veteran with over three decades of life sciences leadership and drug development experience. Dr. Corrigan most recently served as CEO of Tremeau Pharmaceuticals, a non-opioid pain company that he co-founded. Dr. Corrigan previously served as CEO of Correvio Pharma Corp, leading their acquisition by Advanz Pharma in 2021. Prior to that, he served as Executive Vice President, Research and Development, at Sepracor. Prior to joining Sepracor, Dr. Corrigan spent 10 years with Pharmacia & Upjohn, culminating as Vice President of Global Clinical Research and Experimental Medicine. Dr. Corrigan serves as Chairman of the Board of Elios Therapeutics and as a member of the Board of Wave Life Sciences and Trevena Pharmaceuticals. Dr. Corrigan previously served on the Board of Cubist prior to its acquisition by Merck and on the Board of Avanir prior to its acquisition by Otsuka. Dr. Corrigan holds a B.A. and M.D. from the University of Virginia and received specialty training in psychiatry at Maine Medical Center and Cornell University. About scp776 Scp776 is Silver Creek's lead investigational therapy. Scp776 is a first-in-class, targeted fusion protein that harnesses the cell survival function of insulin-like growth factor 1 (IGF-1). Scp776 is currently being evaluated in ARPEGGIO, a Phase II study for the treatment of acute ischemic stroke (NCT05585606). About ARPEGGIO ARPEGGIO (NCT05585606) is a randomized, placebo-controlled Phase II study evaluating the safety and neuroprotective capacity of scp776 in subjects undergoing endovascular thrombectomy for acute ischemic stroke. ARPEGGIO is actively enrolling subjects at multiple centers across the United States. For more information, please visit . About Silver Creek Pharmaceuticals Silver Creek is a clinical-stage biotechnology company headquartered in San Francisco, CA. Silver Creek's Smart Growth Factor™ technology enables the rapid development of targeted therapeutics with broad scope and applicability. Our lead asset, scp776, is a first-in-class, targeted fusion protein that harnesses the cell survival function of IGF-1. For more information about Silver Creek, please visit . Media Contact: Corey MacGregor VP, New Products Planning Silver Creek Pharmaceuticals [email protected] SOURCE Silver Creek Pharmaceuticals, Inc.

CHESTERBROOK, Pa. , July 20, 2023 (GLOBE NEWSWIRE) -- Trevena, Inc. (Nasdaq: TRVN), a biopharmaceutical company focused on the development and commercialization of novel medicines for patients with central nervous system (CNS) disorders, today announced that Mark Corrigan, M.D. has been appointed to the Company’s Board of Directors, effective July 18 2023. “We are pleased to welcome Mark to Trevena’s Board of Directors,” said Carrie Bourdow, Trevena’s President and CEO. “Mark has over 30 years of experience in the life sciences industry and broad neuroscience expertise. He will be an invaluable member of the Board and guide to the management team as we continue to execute on our corporate strategy and advance our novel S1P receptor modulator, TRV045, for the potential treatment of epilepsy and chronic pain.” “This is a very exciting time for Trevena, a company with the proven ability to take a novel product from initial discovery through development, approval and launch,” said Dr. Corrigan. “Trevena has an innovative pipeline of wholly owned CNS assets, and I am particularly excited about the many near-term milestones, including data readouts from the two proof-of-concept studies for TRV045.” Dr. Corrigan is a highly successful pharmaceutical executive with more than 30 years of industry experience. Dr. Corrigan has served as Chief Executive Officer of Tremeau Pharmaceuticals, a pharmaceutical company that Dr. Corrigan co-founded, since January 2023. Dr. Corrigan has also served on the Board of Directors of Tremeau since April 2017. Prior to his appointment as CEO of Tremeau, Dr. Corrigan served as Chief Executive Officer of Correvio Pharma Corp, a specialty pharmaceutical company, and prior to that as President of Research & Development of Tremeau. Dr. Corrigan serves as Chairman of the Board of Directors of Elios Therapeutics and as a member of the Board of Directors of Nabriva Therapeutics and Wave Life Sciences. In addition, Dr. Corrigan is currently a visiting professor in the Department of Psychiatry at Brigham and Women’s Hospital in Boston, MA. Dr. Corrigan previously served on the Board of Directors of Cubist Pharmaceuticals, a hospital acute care focused company, prior to its approximately $9.5 billion acquisition by Merck. He also served as a member of the Board of Directors and Chair of the Scientific Advisory Committee of Avanir Pharmaceuticals, a CNS focused company, prior to its approximately $3.5 billion acquisition by Otsuka Pharmaceutical. Dr. Corrigan holds a B.A. and M.D. from the University of Virginia and received specialty training in psychiatry at Maine Medical Center and Cornell University. About Trevena Trevena, Inc. is a biopharmaceutical company focused on the development and commercialization of innovative medicines for patients with CNS disorders. The Company has one approved product in the United States, OLINVYK® (oliceridine) injection, indicated in adults for the management of acute pain severe enough to require an intravenous opioid analgesic and for whom alternative treatments are inadequate. The Company’s novel pipeline is based on Nobel Prize winning research and includes three differentiated investigational drug candidates: TRV045 for diabetic neuropathic pain and epilepsy, TRV250 for the acute treatment of migraine and TRV734 for maintenance treatment of opioid use disorder. For more information, please visit www.Trevena.com About TRV045 TRV045 is a novel, selective sphingosine-1-phosphate subtype 1 (S1P1) receptor modulator being developed as a potential treatment for acute and chronic neuropathic pain secondary to diabetic peripheral neuropathy. Through a collaboration with the National Institutes of Health, Trevena is also exploring TRV045 as a potential treatment for epilepsy. S1P receptors are located throughout the body, including the central nervous system, where they are believed to play a role in modulating neurotransmission and membrane excitability. Trevena's discovery efforts have identified a family of compounds that are highly selective for the S1P1 receptor. TRV045 reversed thermal hyperalgesia, a measure of neuropathic pain, in nonclinical models of diabetic peripheral neuropathy and chemotherapy-induced peripheral neuropathy. TRV045 was not associated with lymphopenia and produced no changes in blood pressure, heart rate, or respiratory function at or above pharmacologically active doses in nonclinical studies. TRV045 is an investigational product and is not yet approved by the FDA. Forward-Looking Statements Any statements in this press release about future expectations, plans and prospects for the Company, including statements about the Company’s strategy, future operations, clinical development and trials of its therapeutic candidates and approved product, plans for potential future product candidates and other statements containing the words “anticipate,” “believe,” “estimate,” “expect,” “intend,” “may,” “plan,” “predict,” “project,” “suggest,” “target,” “potential,” “will,” “would,” “could,” “should,” “continue,” and similar expressions, constitute forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including: the status, timing, costs, results and interpretation of the Company’s clinical trials or any future trials of any of the Company’s investigational drug candidates; the uncertainties inherent in conducting clinical trials; expectations for regulatory interactions, submissions and approvals, including the Company’s assessment of discussions with FDA; available funding; uncertainties related to the Company’s intellectual property; uncertainties related to the ongoing COVID-19 pandemic, other matters that could affect the availability or commercial potential of the Company’s therapeutic candidates and approved product; and other factors discussed in the Risk Factors set forth in the Company’s Annual Report on Form 10-K and Quarterly Reports on Form 10-Q filed with the Securities and Exchange Commission (SEC) and in other filings the Company makes with the SEC from time to time. In addition, the forward-looking statements included in this press release represent the Company’s views only as of the date hereof. The Company anticipates that subsequent events and developments may cause the Company’s views to change. However, while the Company may elect to update these forward-looking statements at some point in the future, it specifically disclaims any obligation to do so, except as may be required by law. For more information, please contact: Investor Contact: Dan FerryManaging DirectorLifeSci Advisors, LLCdaniel@lifesciadvisors.com(617) 430-7576 Company Contact: Bob YoderSVP and Chief Business OfficerTrevena, Inc.(610) 354-8840

AUSTIN, Texas, Sept. 29, 2021 /PRNewswire/ -- Elios Therapeutics, LLC , an immuno-oncology company focused on the development and commercialization of next-generation, immune-mediated technologies for the treatment of cancer, today announced the appointment of Michael Caprio, C.P.A., an accomplished business executive, to the Company's Board of Directors. For over three decades, Michael has demonstrated leadership in guiding business strategy for many organizations, including business development, quality control and personnel development. "Michael has exceptional experience in guiding the financial strategy of high-growth and businesses which will be invaluable as we advance our lead vaccine candidates into a Phase III registrational trial and expand our therapeutic platform into other indications," said Buddy Long, chief executive officer of Elios Therapeutics. "On behalf of the leadership team, we are pleased to welcome Michael to our Board of Directors during this important period of growth and evolution for Elios." About Michael Caprio Caprio currently serves as an independent consultant providing financial and litigation expertise after a 32-year career as an audit partner with KPMG, an international accounting and advisory firm. At KPMG, Michael held several leadership positions, including National Industrial Markets Audit Leader, Partner in Charge - Audit of the New England Business Unit, Managing Partner of the Providence, Rhode Island office and Global Lead Partner for several exchange listed companies. Michael has served on the board of directors of professional, philanthropic, and social organizations, including KATANA Safety and the Greater Providence Chamber of Commerce, RI. He has extensive experience in mergers and acquisitions, operating multi-site professional services, SEC Regulations, Initial Public Offerings, private equity, board and investor communications, litigation support, accounting and internal control. Michael is a graduate of the University of Connecticut and is a certified public accountant. "I am delighted to have the opportunity to join the Elios Board at this pivotal time in the Company's life cycle," said Michael Caprio. "Cancer is among the leading causes of death worldwide and Elios has made great strides in advancing its immunotherapy platform of therapeutic cancer vaccines which may transform the way we treat cancer. I look forward to contributing my experience and helping to further the Company's efforts to deliver promising therapeutic options for the cancer community." About Elios Therapeutics, LLC Elios Therapeutics, LLC is an immuno-oncology company focused on the development and commercialization of next-generation, immune-mediated technologies for the treatment of cancer, developing a portfolio of innovative personalized therapeutic cancer vaccines targeting unmet medical needs across a broad range of tumor types. Elios holds exclusive licenses for two lead therapeutic candidates, the TLPLDC (tumor lysate, particle-loaded, dendritic cell) vaccine and TLPO (tumor lysate, particle only) vaccine, personalized therapeutic cancer vaccines that use a proprietary particle delivery system to stimulate the body's immune system to recognize cancer cells as foreign pathogens and fight a patient's specific cancer. Elios is investigating the clinical potential of TLPLDC and TLPO in U.S. Food and Drug Administration clinical trials. For more information, please visit . Forward-Looking Statements This document contains forward–looking statements relating to the Company's strategy, objectives, business development plans and financial position. All statements other than statements of historical facts included in this document, including, without limitation, statements regarding the Company's future financial position, strategy, anticipated investments, costs and results, status and results of clinical trials, size of patient population, plans, outcomes of product development efforts, and objectives of management for future operations, may be deemed to be forward–looking statements. You can identify forward-looking statements by words such as "anticipate," "believe," "could," "estimate," "expect," "intend," "may," "plan," "potential," "predict," "project," "should," "will," "would" or the negative of those terms, and similar expressions that convey uncertainty or future events or outcomes. These forward–looking statements involve known and unknown risks, uncertainties, and other factors that may cause the Company's actual results, performance, or achievements or industry results to be materially different from those contemplated, projected, forecasted, estimated or budgeted, whether expressed or implied, by these forward–looking statements. Given these risks and uncertainties, investors should not place undue reliance on forward–looking statements as a prediction of actual results. None of these forward–looking statements constitutes a guarantee of the future occurrence of such events or of actual results. These statements are based on data, assumptions, and estimates that the Company believes are reasonable. The forward–looking statements contained in this document are made only as of the date hereof. Except as otherwise required by law, the Company expressly disclaims any obligation or undertaking to release publicly any updates of any forward-looking statements contained in this document to reflect any change in its actual results, assumptions, expectations or any change in events, factors, conditions, or circumstances on which any forward–looking statement contained in this document is based. Contacts: Media Relations Melyssa Weible Elixir Health Public Relations +1 (201) 723-5805 mweible@elixirhealthpr.com