Comparative analysis of the effect of calorie free sweeteners and probiotics on the oral microbial concentration in children: a randomised controlled trial - NIL

开始日期2024-10-04

申办/合作机构

Saveetha Engineering College

CTRI/2024/07/071754 / Not yet recruitingN/A

Comparative study of an Application for Anaesthetist for Drug dose and toxic dose calculation Versus Conventional Methods for Pediatric Drug Dose Calculation in general anesthesia - A Randomized Controlled Trial - NIL

开始日期2024-09-01

申办/合作机构

Saveetha Engineering College

CTRI/2024/08/071768 / Not yet recruiting临床4期

Comparing Child Acceptance Silver Diamine Fluoride versus Sodium Varnish for Pediatric Dental Treatment

开始日期2024-08-29

申办/合作机构

Saveetha Engineering College

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1,416

项与 Saveetha Engineering College 相关的文献（医药）

2024-12-01·Recent Advances in Drug Delivery and Formulation

Optimizing Microfluidic Channel Design with High-Performance Materials for Safe Neonatal Drug Delivery

Article

作者: ARCHANA, T ; Nachammai, N. ; Praveenkumar, S. ; Archana, T.

Introduction:Designing the microfluidic channel for neonatal drug delivery requires proper considerations to enhance the efficiency and safety of drug substances when used in neonates. Thus, this research aims to evaluate high-performance materials and optimize the channel design by modeling and simulation using COMSOL multiphysics in order to deliver an optimum flow rate between 0. 3 and 1 mL/hr.Methods:Some of the materials used in the study included PDMS, glass, COC, PMMA, PC, TPE, and hydrogels, and the evaluation criterion involved biocompatibility, mechanical properties, chemical resistance, and ease of fabrication. The simulation was carried out in the COMSOL multiphysics platform and demonstrated the fog fluid behavior in different channel geometries, including laminar flow and turbulence. The study then used systematic changes in design parameters with the aim of establishing the best implementation models that can improve the efficiency and reliability of the drug delivery system. The comparison was based mostly on each material and its appropriateness in microfluidic usage, primarily in neonatal drug delivery. The biocompatibility of the developed materials was verified using the literature analysis and adherence to the ISO 10993 standard, thus providing safety for the use of neonatal devices. Tensile strength was included to check the strength of each material to withstand its operation conditions. Chemical resistance was also tested in order to determine the compatibility of the materials with various drugs, and the possibility of fabrication was also taken into consideration to identify appropriate materials that could be used in the rapid manufacturing of the product.Results:The results we obtained show that PDMS, due to its flexibility and simplicity in simulation coupled with more efficient channel designs which have been extracted from COMSOL, present a feasible solution to neonatal drug delivery.Conclusion:The present comparative study serves as a guide on the choice of materials and design of microfluidic devices to help achieve safer and enhanced drug delivery systems suitable for the delicate reception of fragile neonates.

2024-12-01·Recent Advances in Electrical & Electronic Engineering (Formerly Recent Patents on Electrical & Electronic Engineering)

Solar and Wind-based Renewable DGs and DSTATCOM Allotment in Distribution System with Consideration of Various Load Models Using Spotted Hyena Optimizer Algorithm

作者: Yuvaraj, Thangaraj ; Balamurugan, Pottukkannan ; Babu, Nudhurupati Venkata Phanendra ; Joly, Maheswaran ; Suresh, Thirukoilur Dhandapani

Background:This article presents a novel strategy that utilizes the nature-inspired Spotted Hyena Optimizer Algorithm (SHOA) to optimize the placement of solar and wind-based renewable distributed generation (RDG) and distribution static compensators (DSTATCOMs) in radial distribution systems (RDS).Methods:The proposed technique aims to determine the optimal locations of DSTATCOM and RDGs based on the loss sensitivity factor (LSF), while the appropriate sizes are determined using the newly developed SHOA. To facilitate efficient load flow calculations, a fast and effective backward/forward sweep algorithm (BFSA) is employed.Results:The primary objective of this method is to minimize overall power losses within the system. The effectiveness of the optimization approach based on SHOA is demonstrated through extensive simulations conducted on a standard IEEE 33-bus test system with diverse load models.Conclusion:The results of the simulations and comparisons of multiple case studies clearly indicate that the allocation of DSTATCOMs leads to significant reductions in power losses and improvements in voltage profiles.

2024-12-01·Recent Advances in Electrical & Electronic Engineering (Formerly Recent Patents on Electrical & Electronic Engineering)

Mitigation of the Impact of Incorporating Charging Stations for Electric Vehicles Using Solar-based Renewable DG on the Electrical Distribution System

作者: Yuvaraj, Thangaraj ; Balamurugan, Pottukkannan ; Suresh, Thirukoilur Dhandapani ; Selvi, Selvaraj

Background:The utilization of electric vehicles (EVs) is on the rise, which has led to significant challenges for the radial distribution system (RDS). This research aimed to investigate the impact of electric vehicle charging stations (EVCS) on power loss, voltage stability, and reliability within the RDS. Solar-based renewable distributed generation (SRDG) offers a range of benefits in mitigating the impact of EVCS on the distribution system. To simulate the integration of EV charging loads and assess their effects on the RDS, the study has employed the widely used IEEE 69-bus system as a test platform.Methods:A novel approach utilizing the cuckoo search algorithm (CSA) is presented in this article to determine the optimal locations for EVCS and SRDG.Results:The study has examined the potential power losses resulting from additional EV loads and explored strategies to optimize charging rates and minimize resistive losses. Voltage stability has been assessed by analyzing the voltage drop caused by high charging loads, and the efficiency of voltage regulation devices and control strategies has been evaluated. Moreover, the paper has discussed the reliability implications of EV charging, including localized overloads and the possibility of outages.Conclusion:Overall, this research has enhanced our understanding of the challenges associated with integrating EVCS into the RDS and offered potential solutions to address these challenges.

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