Impact of Hippocampal-Avoidance Whole-Brain Radiotherapy on Cognitive Function, Employment Status, and Quality of Life in Working-Age Populations: A Prospective Observational Study - Prospective observational study for hippocampal-avoidance whole-brain radiotherapy

开始日期2024-05-30

申办/合作机构

Aichi Cancer Center Research Institute

JPRN-UMIN000052528 / RecruitingIIT

Phase I trial for lavage cytology tests collected by EUS-FNA for preoperative pancreatic cancer patients. - Phase I trial of EUS-guided lavage cytology tests for preoperative pancreatic cancer patients

开始日期2023-06-02

申办/合作机构

Aichi Cancer Center Research Institute

JPRN-UMIN000052615 / RecruitingIIT

A clinical study of a remote lifestyle support program for cancer patients receiving systemic chemotherapy - A clinical study of a remote lifestyle support program for cancer patients receiving systemic chemotherapy

开始日期2023-06-01

申办/合作机构

Aichi Cancer Center Research Institute

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2,754

项与 Aichi Cancer Center Research Institute 相关的文献（医药）

2024-12-31·OncoImmunology

Candidate tumor-specific CD8 ⁺ T cell subsets identified in the malignant pleural effusion of advanced lung cancer patients by single-cell analysis

Article

作者: Sugita, Yusuke ; Horio, Yoshitsugu ; Clancy, Trevor ; Yamashita, Yoshiko ; Muraoka, Daisuke ; Ishibashi, Hironori ; Demachi-Okamura, Ayako ; Yamaguchi, Rui ; Komuro, Hiroyasu ; Tanaka, Yuki ; Kuroda, Hiroaki ; Matsui, Takuya ; Onoue, Kousuke ; Hashimoto, Kana ; Shinohara, Shuichi ; Sasaki, Eiichi ; Masago, Katsuhiro ; Matsushita, Hirokazu ; Miura, Daiki ; Hamana, Hiroshi ; Takashima, Chieko ; Onoguchi, Kazuhide ; Takahashi, Yusuke ; Tanaka, Ichidai ; Kishi, Hiroyuki ; Okubo, Kenichi ; Yamaguchi, Teppei ; Fukushima, Yasunori ; Nishida, Reina ; Stratford, Richard

Isolation of tumor-specific T cells and their antigen receptors (TCRs) from malignant pleural effusions (MPE) may facilitate the development of TCR-transduced adoptive cellular immunotherapy products for advanced lung cancer patients. However, the characteristics and markers of tumor-specific T-cells in MPE are largely undefined. To this end, to establish the phenotypes and antigen specificities of CD8⁺ T cells, we performed single-cell RNA and TCR sequencing of samples from three advanced lung cancer patients. Dimensionality reduction on a total of 4,983 CD8⁺ T cells revealed 10 clusters including naïve, memory, and exhausted phenotypes. We focused particularly on exhausted T cell clusters and tested their TCR reactivity against neoantigens predicted from autologous cancer cell lines. Four different TCRs specific for the same neoantigen and one orphan TCR specific for the autologous cell line were identified from one of the patients. Differential gene expression analysis in tumor-specific T cells relative to the other T cells identified CXCL13, as a candidate gene expressed by tumor-specific T cells. In addition to expressing CXCL13, tumor-specific T cells were present in a higher proportion of T cells co-expressing PDCD1(PD-1)/TNFRSF9(4-1BB). Furthermore, flow cytometric analyses in advanced lung cancer patients with MPE documented that those with high PD-1/4-1BB expression have a better prognosis in the subset of 57 adenocarcinoma patients (p = .039). These data suggest that PD-1/4-1BB co-expression might identify tumor-specific CD8⁺ T cells in MPE, which are associated with patients' prognosis. (233 words).

2024-10-05·Journal of Epidemiology

Confounding in Epidemiological Studies on Assessment of the Impact of Genetic Factors on Disease Risk: The Problem of Redundant Adjustment

Article

作者: Kasugai, Yumiko ; Koyanagi, Yuriko N. ; Matsuo, Keitaro ; Imoto, Issei ; Oze, Isao ; Taniyama, Yukari ; Ito, Hidemi

2024-10-01·Cytotherapy

Center effect on allogeneic hematopoietic stem cell transplantation outcomes for B-cell acute lymphoblastic leukemia

Article

作者: Hashii, Yoshiko ; Kato, Koji ; Kanda, Junya ; Sato, Atsushi ; Goto, Hideki ; Arai, Yasuyuki ; Yanagisawa, Atsumi ; Ohbiki, Marie ; Kurosawa, Shuhei ; Atsuta, Yoshiko ; Ishimaru, Fumihiko ; Fukuda, Takahiro ; Matsuo, Keitaro ; Ichinohe, Tatsuo ; Yoshimitsu, Makoto ; Ito, Yuri ; Tabuch, Ken ; Onizuka, Makoto

This nationwide study retrospectively examined the center effect on allogeneic hematopoietic stem cell transplantation (allo-HSCT) for adult B-cell acute lymphoblastic leukemia. The cohort analyses were separated into Philadelphia chromosome (Ph)-positive and -negative cases. The patients were divided into low- and high-volume groups according to the number of allo-HSCTs at each facility. The primary endpoint was 5-year overall survival (OS). This study included 1156 low-volume and 1329 high-volume Ph-negative and 855 low-volume and 926 high-volume Ph-positive cases. In Ph-negative cases, 5-year OS was significantly higher in the high-volume centers at 52.7% (95% confidence interval [CI]: 49.9-55.5) versus 46.8% (95% CI: 43.8-49.7) for the low-volume centers (P < 0.01). Multivariate analysis identified high volume as a favorable prognostic factor (hazard ratio [HR]: 0.81 [95% CI: 0.72-0.92], P < 0.01). Subgroup analysis in Ph-negative cases revealed that the center effects were more evident in patients aged ≥40 years (HR: 0.72, 95% CI: 0.61-0.86, P < 0.01) and those receiving cord blood transplantation (HR: 0.62, 95% CI: 0.48-0.79, P < 0.01). In Ph-positive cases, no significant difference was observed between the high and low-volume centers for 5-year OS (59.5% [95% CI: 56.2-62.7] vs. 54.9% [95% CI: 51.3-58.3], P = 0.054). In multivariate analysis, center volume did not emerge as a significant prognostic indicator. This study showed center effects on survival in Ph-negative but not in Ph-positive cases, highlighting the heterogeneity of the center effect in allo-HSCT for B-cell acute lymphoblastic leukemia. Collaborative efforts among transplant centers and further validation are essential to improve outcomes.

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