Acute and Chronic respiratory conditions represent a leading cause of death and morbidity in children and adults worldwide. The diagnosis of bronchiolitis and asthmatic exacerbations is based on clinical, and mostly subjective, clinical parameters with moderately accurate prognostic role. Patients undergoing neck radiotherapy need invasive assessments of larynx. A simple biomarker like Voice may facilitate the management of these conditions. Recent studies showed that VOICE may be used as a good and easy biomarker to diagnose and monitor several respiratory and non-respiratory conditions. A prospective study aimed to collected VOICE and other clinical data in adults and children with common acute and chronic respiratory conditions at high impact on healthcare systems will be performed. VOICE-omic data will be linked with clinical findings generating data integration, using artificial intelligence technology to develop a Decision Support Systems to provide the basis for non-invasive personalised early recognition, diagnosis, monitoring and prognosis of patients with these conditions.

开始日期2024-11-30

申办/合作机构

University Hospital Agostino Gemelli

NCT06664528 / Not yet recruitingN/A

Cardiovascular Health and Prognosis in Adult Patients With Cancer Exposed to Cardiotoxic Therapies, an Observational Study

The goal of this observational study is to evaluate the cardiovascular health and prognosis of adult patients with cancer treated with cardiotoxic therapies.
The main purposes of the study are the following:
* Identify the demographic factors related to the onset of cardiotoxicity produced by anticancer drugs.
* Identify any subgroups more likely to develop distant major adverse cardiovascular events (MACE).
* Evaluate the usefulness of clinical, biohumoral and echocardiographic parameters for early diagnosis of cardiotoxicity.
Participants will be monitored during the anticancer treatment via clinical, laboratory and instrumental evaluation according to the recommendation of the current guidelines on Cardio-Oncology (European Society of Cardiology, 2022). Initial follow-up will be 2 years.

开始日期2024-11-15

申办/合作机构

University Hospital Agostino Gemelli

NCT06574386 / Not yet recruitingN/A

Pregnancy in GUCH Patients: Maternal-Foetal-Neonatal Aspects at Mid Term

This study aims to investigate the impact of congenital heart diseases on maternal and foetal-neonatal health, the effect of pregnancy on maternal cardiac health, and the outcome of newborns/children born from Grown-Up Congenital Heart (GUCH) mothers with follow-up at one year, extendable to two.
The main question it aims to answer is:
-Does maternal congenital heart disease affects outcomes of newborn?

开始日期2024-11-01

申办/合作机构

University Hospital Agostino Gemelli

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项与 University Hospital Agostino Gemelli 相关的文献（医药）

2024-12-01·Cellular and Molecular Life Sciences

Glycine-induced activation of GPR158 increases the intrinsic excitability of medium spiny neurons in the nucleus accumbens

Article

作者: Nutarelli, Sofia ; Aceto, Giuseppe ; Pecci, Valeria ; Nardella, Luca ; Colussi, Claudia ; Viscomi, Maria Teresa ; D'Ascenzo, Marcello ; Nanni, Simona ; Bertozzi, Alessia ; Grassi, Claudio

AbstractIt has been recently established that GPR158, a class C orphan G protein-coupled receptor, serves as a metabotropic glycine receptor. GPR158 is highly expressed in the nucleus accumbens (NAc), a major input structure of the basal ganglia that integrates information from cortical and subcortical structures to mediate goal-directed behaviors. However, whether glycine modulates neuronal activity in the NAc through GPR158 activation has not been investigated yet. Using whole-cell patch-clamp recordings, we found that glycine-dependent activation of GPR158 increased the firing rate of NAc medium spiny neurons (MSNs) while it failed to significantly affect the excitability of cholinergic interneurons (CIN). In MSNs GPR158 activation reduced the latency to fire, increased the action potential half-width, and reduced action potential afterhyperpolarization, effects that are all consistent with negative modulation of potassium M-currents, that in the central nervous system are mainly carried out by Kv7/KCNQ-channels. Indeed, we found that the GPR158-induced increase in MSN excitability was associated with decreased M-current amplitude, and selective pharmacological inhibition of the M-current mimicked and occluded the effects of GPR158 activation. In addition, when the protein kinase A (PKA) or extracellular signal-regulated kinase (ERK) signaling was pharmacologically blocked, modulation of MSN excitability by GPR158 activation was suppressed. Moreover, GPR158 activation increased the phosphorylation of ERK and Kv7.2 serine residues. Collectively, our findings suggest that GPR158/PKA/ERK signaling controls MSN excitability via Kv7.2 modulation. Glycine-dependent activation of GPR158 may significantly affect MSN firing in vivo, thus potentially mediating specific aspects of goal-induced behaviors.

2024-11-01·Journal of the Neurological Sciences

Racial and ethnic differences in access to care and treatment in patients with suspected acute stroke: A retrospective, observational, cohort study

Article

作者: Di Giovanni, Jacopo ; Frisullo, Giovanni ; Calabresi, Paolo ; Bellavia, Simone ; Gasbarrini, Antonio ; Covino, Marcello ; Carbone, Luigi ; Broccolini, Aldobrando ; Franceschi, Francesco ; Monforte, Mauro ; Scala, Irene ; Rizzo, Pier Andrea

BACKGROUNDData regarding unequal diagnostic and therapeutic access in patients with acute stroke based on ethnicity and race are inconclusive in Europeans. The objectives of our study were to evaluate the effect of race/ethnicity on access to acute stroke care and treatments and outcomes.METHODSIn this retrospective cohort study, we enrolled adult patients admitted to the emergency department of a comprehensive stroke center for suspected stroke. Based on race/ethnicity, patients were divided into two main groups: Western European Whites (WEW) and non-Western European Whites (nWEW). We also divided the nWEW group into four subgroups based on the Office of Management and Budget classification of human races and ethnicities (White-Others, Hispanic, Asian, Black). Univariate comparisons and logistic regression analyses were also performed.RESULTS9167 patients were enrolled in the study: 582 in the nWEW and 8585 in the WEW group. Patients with ischemic stroke in the nWEW group were significantly younger than those in the other group (p < 0.001). Once adjusted for possible confounders, belonging to the nWEW group was found to be an independent predictor of a lower likelihood of receiving revascularization treatments (p = 0.006), regardless similar onset-to-door times. There were no differences in stroke outcomes and prevalence of stroke mimic diagnosis between the groups.CONCLUSIONSRacial/ethnic disparities in healthcare represent a challenging issue, even in universal healthcare systems, that should be addressed promptly through education campaigns of healthcare personnel and implementation measures, such as integrating readily available interpreter staff for medical emergencies.

2024-11-01·Neurological Sciences

Thrombectomy in ischemic stroke patients with tandem occlusion in the posterior versus anterior circulation

Article

作者: Besana, Michele ; Semeraro, Vittorio ; Sacco, Simona ; Napoletano, Rosa ; Filizzolo, Marco ; Calzoni, Andrea ; Mannino, Marina ; Lazzarotti, Guido Andrea ; Critelli, Adriana ; Tassinari, Tiziana ; Lafe, Elvis ; Romano, Daniele ; Russo, Monia ; La Spina, Paolino ; Toni, Danilo ; Casetta, Ilaria ; Naldi, Andrea ; Zini, Andrea ; Capasso, Francesco ; Invernizzi, Paolo ; Cavallini, Anna ; Franchini, Enrica ; Vallone, Stefano ; Cavasin, Nicola ; Pedicelli, Alessandro ; Cappellari, Manuel ; Fainardi, Enrico ; Amistà, Pietro ; Scoditti, Umberto ; Sepe, Federica ; Mandruzzato, Nicolò ; Simonetti, Luigi ; Filauri, Pietro ; Cariddi, Lucia Princiotta ; Malfatto, Laura ; Rizzo, Annalisa ; Diomedi, Marina ; Petruzzellis, Marco ; Cerrato, Paolo ; Saletti, Andrea ; Comai, Alessio ; Pracucci, Giovanni ; Boero, Giovanni ; Ruggiero, Maria ; Giannini, Nicola ; Castellan, Lucio ; Giossi, Alessia ; Sallustio, Fabrizio ; Nencini, Patrizia ; Bigliardi, Guido ; Giorgianni, Andrea ; Biraschi, Francesco ; Tassi, Rossana ; Menozzi, Roberto ; Tessitore, Agostino ; Florio, Francesco ; Zimatore, Domenico Sergio ; De Vito, Alessandro ; Bracco, Sandra ; Inchingolo, Vincenzo ; Saia, Valentina ; Lozupone, Emilio ; Gallesio, Ivan ; Pavia, Marco ; Mangiafico, Salvatore ; Frisullo, Giovanni ; Longoni, Marco ; Da Ros, Valerio ; Valletta, Francesco ; Boghi, Andrea ; Bergui, Mauro ; Nicolini, Ettore

BACKGROUNDMechanical thrombectomy (MT) was found to be beneficial in acute ischemic stroke patients with anterior tandem occlusion (a-TO). Instead, little is known about the effectiveness of MT in stroke patients with posterior tandem occlusion (p-TO). We aimed to compare MT within 24 h from last known well time in ischemic stroke patients with p-TO versus a-TO.METHODSWe conducted a cohort study on prospectively collected data of patients registered in the Italian Registry of Endovascular Treatment in Acute Stroke (IRETAS) who were treated with MT within 24 h from last known well time for acute ischemic stroke with p-TO (n = 275) or a-TO (n = 1853).RESULTSAfter adjustment for unbalanced pre-procedure variables (year 2015-2021, age, sex, NIHSS score, ASPECTS, and time strata for puncture groin) and pre-stroke mRS score as pre-defined predictor, p-TO was significantly associated with lower probability of mRS score 0-2 (OR 0.415, 95% CI 0.268-0.644) and with higher risk of death (OR 2.813, 95% CI 2.080-3.805) at 3 months. After adjustment for unbalanced procedural and post-procedure variables (IVT, general anesthesia, TICI 3, and 24-h HT) and pre-stroke mRS score as pre-defined predictor, association between p-TO and lower probability of mRS score 0-2 (OR 0.444, 95% CI 0.304-0.649) and association between p-TO and with higher risk of death (OR 2.971, 95% CI 1.993-4.429) remained significant.CONCLUSIONSMT within 24 h from last known well time in ischemic stroke patients with p-TO versus a-TO was associated with worse outcomes at 3 months.

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