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1

项与 Selectide Corp. 相关的药物

SEL-2711

靶点

factor Xa

作用机制

factor Xa抑制剂

在研机构-

原研机构

Selectide Corp.

在研适应症-

非在研适应症

血栓栓塞

最高研发阶段无进展

首次获批国家/地区-

首次获批日期-

100 项与 Selectide Corp. 相关的临床结果

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0 项与 Selectide Corp. 相关的专利（医药）

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56

项与 Selectide Corp. 相关的文献（医药）

1999-07-01·Expert Opinion on Therapeutic Patents

Factor Xa inhibitors

作者: Al-Obeidi, F. ; Ostrem, J. A.

A review with 129 referencesFactor Xa is a key enzyme in the production of thrombin from its precursor prothrombin and is an important target for antithrombotic drug development.The patient literature for the last four to five years illustrates a variety of peptide and non-peptide Factor Xa inhibitors, including small proteins isolated from natural sources, rationally designed peptides and peptidomimetics based on substrate cleavage sites, and non-peptide small mols. derived from screening and rational design.This report reviews the status of the patent literature in the field of Factor Xa inhibitors through 1998.

1998-05-01·The Journal of Organic Chemistry

Solid-Phase Synthesis of Heterocycles Containing an 1-Acyl-3-oxopiperazine Skeleton

作者: Weichsel, Aleksandra ; Vojkovský, Tomáš ; Pátek, Marcel

A new acetal-type linker was synthesized by attachment of bromoacetaldehyde di-Et acetal to the TentaGel OH resin.Transformation of the resulting bromoacetal resin into the corresponding aminoacetals, followed by acylation with a number of amino acids provided solid phase-bound peptoid-aldehyde dialkyl acetals.Subsequent acylation with a number of acyl components containing different nucleophilic centers afforded polymer-bound products in nearly quant. overall yields.Upon treatment with formic acid, new bi-, tri-, and tetracyclic derivatives of 1-acyl-3-oxopiperazines were obtained via a tandem N-acyliminium ion cyclization-nucleophilic addition reaction sequence.General availability of amines and amino acids enhances the utility of these reactions for the construction of large combinatorial libraries of peptidomimetics and heterocycles bearing one or two heteroatoms.

1996-10-01·Molecular Diversity3区 · 化学

Library generation through successive substitution of trichlorotriazine

3区 · 化学

Article

作者: Michal Lebl ; Magda Stanková

The decreasing reactivity of tri-, di- and monochlorotriazine was utilized for the solid-phase construction of a combinatorial library with three randomized positions, using 20 amino acids and 50 amines as building blocks. The first chlorine atom was selectively substituted by coupling a large excess of trichlorotriazine to the support-bound amino acid, thus avoiding simultaneous substitution of the second chlorine. The second and third diversity positions were selectively introduced by coupling amines at different temperatures. Mixtures of model compounds were synthesized and analyzed, showing the correct representation of all expected components. A library composed of 12,000 compounds was generated using this method.

100 项与 Selectide Corp. 相关的药物交易

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100 项与 Selectide Corp. 相关的转化医学

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