Objective To improve the quality standard for Yangyin Qingfei syrup. Methods TLC identification of the seven materials in Yangyin Qingfei syrup and determinations of harpagoside and paeonol by HPLC method were performed. Results The TLC identification methods for Scrophulariae radix, Paeoniae radix alba, Moutan cortex, Glycyrrhizae radix et rhizome were established, and TLC spots were clear, specific and repeatable. Harpagoside and paeonol had a good linearity in the range of 0.04336-0.4336 μg and 0.20112-2.01112 μg with the average recovery of 98.7% and 98.8%, resp. Conclusion The improved quality standard is simple, rapid and accurate compared to the original standard, which could be better for quality control of Yangyin Qingfei syrup.