Delving into the Latest Updates on Saint Vincent's Catholic Medical Centers with Synapse

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1

项与 Saint Vincent's Catholic Medical Centers 相关的药物

SV BR 1 GM cancer vaccine ( BriaCell Therapeutics)

靶点

CSF-3R

作用机制

CSF-3R激动剂

在研机构

BriaCell Therapeutics Corp.

原研机构

Wiseman Research Initiatives LLC

在研适应症

乳腺癌 [+1]

非在研适应症

卵巢上皮癌

最高研发阶段临床3期

首次获批国家/地区-

首次获批日期-

100 项与 Saint Vincent's Catholic Medical Centers 相关的临床结果

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0 项与 Saint Vincent's Catholic Medical Centers 相关的专利（医药）

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26

项与 Saint Vincent's Catholic Medical Centers 相关的文献（医药）

2011-06-01·The Journal of invasive cardiology4区 · 医学

Prospective, randomized, placebo-controlled evaluation of esomeprazole in coronary artery disease patients. EPAC: esomeprazole prevention of atypical chest pains.

4区 · 医学

Article

作者: Liuzzo, John ; Ambrose, John ; Agarwal, Saurabh ; Korabathina, Ravi ; Deshmukh, Srmiti ; Das, Sajal ; Devoe, Mary ; Coppola, John

BACKGROUNDCoronary artery disease (CAD) patients experience chest pain (CP) from cardiac and non-cardiac etiologies.OBJECTIVEProton pump inhibitor (PPI) treatment of CAD patients with atypical CP would result in less CP, as well as fewer emergency room (ER) visits for CP, medical evaluations, and hospitalizations.METHODSA randomized, prospective, placebo-controlled trial in patients with a history of severe CAD, without current ischemia, and not receiving acid reducing therapy. Patients received esomeprazole 40 mg or placebo daily added to standard cardiac medications for 6 months. The primary endpoint was percentage of patients experiencing CP.RESULTSIn 162 patients randomized, 78 received esomeprazole and 84 received placebo. Esomeprazole significantly reduced the primary endpoint of patients experiencing CP (24.4% versus 54.8%; p < 0.001). The absolute number of CP episodes and CP days was also significantly reduced. Fewer patients experienced the combined endpoint of doctor office/ER visits for CP (19.2% versus 48.8%; p < 0.001), mainly due to significantly fewer office visits for CP (14.1% versus 39.3%; p < 0.001). ER visits for CP trended less with esomeprazole (12.8% versus 22.6%; p = 0.10), as did hospitalizations for CP (14.1% versus 20.2%; p = 0.30). However, the study lacked statistical power to reach these secondary endpoints.CONCLUSIONSConcomitant esomeprazole therapy in CAD patients without active ischemia but with a history of atypical CP reduces number of patients with further CP symptoms and medical office visits for CP. Larger studies are needed to further evaluate PPI treatment on ER CP visits and hospitalizations in this patient population.

2010-11-11·Blood1区 · 医学

Evidence of dysregulation of dendritic cells in primary HIV infection

1区 · 医学

Article

作者: Larsson, Marie ; Dibben, Oliver ; Hu, Nan ; Qin, Li ; Siegal, Frederick ; Subedi, Abhignya ; Valentine, Fred ; Shianna, Kevin V. ; Nadas, Arthur ; Margolis, David ; Shah, Kokila ; Fellay, Jacques ; Bhardwaj, Nina ; Taylor, Elizabeth ; Markowitz, Martin ; Hutt, Richard ; O'Brien, Meagan ; Borrow, Persephone ; Shodell, Michael ; Lifson, Jeffrey ; Garmon, Donald ; Sabado, Rachel Lubong ; Marmor, Michael ; Stacey, Andrea

AbstractMyeloid and plasmacytoid dendritic cells (DCs) are important mediators of both innate and adaptive immunity against pathogens such as HIV. During the course of HIV infection, blood DC numbers fall substantially. In the present study, we sought to determine how early in HIV infection the reduction occurs and whether the remaining DC subsets maintain functional capacity. We find that both myeloid DC and plasmacytoid DC levels decline very early during acute HIV in-fection. Despite the initial reduction in numbers, those DCs that remain in circulation retain their function and are able to stimulate allogeneic T-cell responses, and up-regulate maturation markers plus produce cytokines/chemokines in response to stimulation with TLR7/8 agonists. Notably, DCs from HIV-infected subjects produced significantly higher levels of cytokines/chemokines in response to stimulation with TLR7/8 agonists than DCs from uninfected controls. Further examination of gene expression profiles indicated in vivo activation, either directly or indirectly, of DCs during HIV infection. Taken together, our data demonstrate that despite the reduction in circulating DC numbers, those that remain in the blood display hyperfunctionality and implicates a possible role for DCs in promoting chronic immune activation.

2009-12-01·Coronary Artery Disease4区 · 医学

Transradial cardiac catheterization and percutaneous coronary intervention: a review

4区 · 医学

Review

作者: Coppola, John T ; Shah, Umang H ; Elgharib, Nader Z

Campeau in 1989 and subsequently Kiemeneij and Laarman in 1993 successfully attempted diagnostic cardiac catheterization and percutaneous coronary intervention (PCI), respectively, using the radial artery. Since then, the technique has evolved significantly with improvement in catheters and operators gaining experience in transradial (TR) procedures. Short recovery time, less bleeding complications, and enhanced patient satisfaction made the TR approach a preferred route to perform cardiac catheterization and PCIs in an increasing number of countries. As operators become more comfortable with this approach, they are using it to perform increasingly complex procedures such as rotational atherectomy and opening chronic total occlusions. Despite its increasing acceptance due to the advantages it offers, TR access was used only in about 1.32% of patients who underwent PCI in the US in a report by Rao et al. In this review, we summarize the advantages and disadvantages of the TR approach trying to identify the possible causes of it not being adopted in US.

100 项与 Saint Vincent's Catholic Medical Centers 相关的药物交易

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100 项与 Saint Vincent's Catholic Medical Centers 相关的转化医学

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