Impact of Free Walking Exercise on Obstructive Sleep Apnea Patients With Non-alcoholic Fatty Liver on Liver Enzymes, Degree of Exhaustion, and Quality of Sleep

Research evaluating the impact of continuous positive airway pressure (CPAP) & walking exercise on fatigue severity, liver enzymes and sleeping quality in patients with non-alcoholic fatty liver disease who also have obstructive sleep apnea. Forty patients are divided into two groups: twenty patients CPAP and other twenty patients for CPAP and walking program .

开始日期2024-07-12

申办/合作机构

Ahram Canadian University

NCT06475092 / CompletedN/AIIT

Relation Between Muscle Mass, Total Body Fat, Visceral Fat, Waist Hip Ratio and Sleeping Hours in Patient With Nonspecific Back Pain

Objective: To find out if there are a relation between muscle mass, total body fat, visceral fat, waist hip ratio and sleeping hours in patient with nonspecific back pain.
Design: Cross sectional study. Subjects: 30 male and female patients with age ranged from 25 to 40 years old diagnosed as nonspecific low back pain will participate in this study.
Main measures: the Outcome measures will be including the assessment of muscle mass, total body fat, visceral fat, waist hip ratio and sleeping hours.
Results: The results will be analyzed via co relation test.

开始日期2024-06-26

申办/合作机构

Ahram Canadian University

NCT06475079 / Not yet recruitingN/AIIT

Correlation Between BMI and Craniovertebral Angle and Their Impact on Hand Grip Strength and Neck Functional Disability in Egyptian University Student

Objective: To find the relation between cranio-vertebral angle and hand grip strength in university student mobile users.
Design: cross sectional study. Setting: Ahram Candian University Subjects:100 male and female university students with age ranged from 20 to 30 years old will participate in this study.
Intervention: cross sectional study to detect the relation between cranio-vertebral angle and hand grip strength in university student mobile users.
Main measures:
* FHP app (Pyeongtaek, South Korea) mobile application
* Hand dynamometer (the JAMAR® Hydraulic Hand) (Lupton-Smith et al.,2022)
* Mechanical height and weight scale
* Visual Analogue Scale
* Arabic Neck Disability Index Results: The results will be obtained via one-way analyses of variance (ANOVA).

开始日期2024-06-26

申办/合作机构

Ahram Canadian University

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项与 Ahram Canadian University 相关的文献（医药）

2025-01-01·Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

Nano-scale multi-spectroscopic analysis of the anti-fibromyalgia drug pregabalin based on dihydropyridine ring formation with sustainability and whiteness evaluation

Article

作者: Ibrahim Helmy, Marwa ; Nessim, Christine K ; Mahdi, Wael A ; El Hamd, Mohamed A. ; Alshehri, Sultan ; Mahdi, Wael A. ; Nessim, Christine K. ; El Hamd, Mohamed A ; Obaydo, Reem H. ; Obaydo, Reem H ; El-Maghrabey, Mahmoud

This research addresses the challenge of analyzing pregabalin, a primary amine in a zwitterionic structure, which is difficult to evaluate due to its lack of chromatophore. The study introduces a derivatization assessment using Hantzsch's multicomponent organic reaction to enhance the detectability of pregabalin by forming a highly fluorescent dihydropyridine derivative. This process involves the condensation of pregabalin with acetylacetone and formaldehyde, yielding a yellowish-green compound measurable both colorimetrically at 338 nm and fluorimetrically at an emission wavelength of 486 nm (λ_excitation = 408 nm). The reaction conditions were thoroughly optimized to obtain the highest possible sensitivity, reduce reagent and time consumption, and use safe solvents. The developed method displayed high sensitivity and linearity in the concentration ranges of 4.0 - 20.0 µg/mL in colorimetric assay and reached a nano-scale analysis level of 40 - 2000 ng/mL with a detection limit down to 10 ng/mL when adopting the fluorimetric measurement. Both assessments were rigorously evaluated for their performance, adhering to the International Conference on Harmonization (ICH) standards. The accuracy of these methods was confirmed through the recovery rates of real samples, showing 98.9 ± 0.2 % for colorimetric and 98.2 ± 0.7 % for fluorimetric assessment. The excellent sensitivity of the suggested spectrofluorometric approach led to its use in the measurement of PRG in spiked human urine samples, resulting in particularly good recoveries ranging from 95.3 to 102.8 %. Meanwhile, the Need, Quality, Sustainability (NQS) index looks into how necessary the method is, execution quality (evaluated using the RGB 12 algorithm), and how it fits with the Sustainable Development Goals (SDGs), underlining the benefits of employing natural reagents. The developed approach showed superiority in sensitivity and sustainability compared to previous analytical approaches for pregabalin.

2024-12-01·Applied Microbiology and Biotechnology

Nanosponge hydrogel of octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl) propanoate of Alcaligenes faecalis

Article

作者: El-Housseiny, Ghadir S ; El-Sayed, Sayed E ; Aboshanab, Khaled M ; Abdelaziz, Neveen A

AbstractOctadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl) propanoate (ODHP) was extracted in a previous study from the culture broth of soil isolate Alcaligenes faecalis MT332429 and showed a promising antimycotic activity. This study was aimed to formulate ODHP loaded β-cyclodextrins (CD) nanosponge (NS) hydrogel (HG) to control skin fungal ailments since nanosponges augment the retention of tested agents in the skin. Box-Behnken design was used to produce the optimized NS formulation, where entrapment efficiency percent (EE%), polydispersity index (PDI), and particle size (PS) were assigned as dependent parameters, while the independent process parameters were polyvinyl alcohol % (w/v %), polymer-linker ratio, homogenization time, and speed. The carbopol 940 hydrogel was then created by incorporating the nanosponges. The hydrogel fit Higuchi’s kinetic release model the best, according to in vitro drug release. Stability and photodegradation studies revealed that the NS-HG remained stable under tested conditions. The formulation also showed higher in vitro antifungal activity against Candida albicans compared to the control fluconazole. In vivo study showed that ODHP-NS-HG increased survival rates, wound contraction, and healing of wound gap and inhibited the inflammation process compared to the other control groups. The histopathological examinations and Masson’s trichrome staining showed improved healing and higher records of collagen deposition. Moreover, the permeability of ODHP-NS-HG was higher through rats’ skin by 1.5-folds compared to the control isoconazole 1%. Therefore, based on these results, NS-HG formulation is a potential carrier for enhanced and improved topical delivery of ODHP. Our study is a pioneering research on the development of a formulation for ODHP produced naturally from soil bacteria.Key points• Octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl) propanoate was successfully formulated as a nanosponge hydrogel and statistically optimized.• The new formula exhibited in vitro good stability, drug release, and higher antifungal activity against C. albicans as compared to the fluconazole.• Ex vivo showed enhanced skin permeability, and in vivo analysis showed high antifungal activity as evidenced by measurement of various biochemical parameters and histopathological examination.

2024-12-01·Bioorganic Chemistry

Unveiling the anticancer potential of novel spirooxindole-tethered pyrazolopyridine derivatives

Article

作者: Elsawi, Ahmed E. ; Alhassan, Noura S. ; Abdel-Aziz, Hatem A ; Ayman, Salsabil ; Zubaidi, Ahmad M ; Al-Karmalawy, Ahmed A. ; Abdel-Aziz, Hatem A. ; Nafie, Mohamed S ; Zubaidi, Ahmad M. ; Nafie, Mohamed S. ; Al-Karmalawy, Ahmed A ; Abdulla, Maha-Hamadien ; Eldehna, Wagdy M. ; Elsawi, Ahmed E ; Elaasser, Mahmoud ; Shahin, Mai I. ; Eldehna, Wagdy M ; Ghabbour, Hazem A ; Alhassan, Noura S ; Shahin, Mai I

In the current medical era, human health is confronted with various challenges, with cancer being a prominent concern. Therefore, enhancing the therapeutic arsenal for cancer with a constant influx of novel molecules that selectively target tumor cells while displaying minimal toxicity toward normal cells is imperative. This study delves into the antiproliferative and EGFR kinase inhibitory activities of newly reported spirooxindole-pyrazolo[3,4-b]pyridine derivatives 8a-h and 10a-h. The inhibitory effects on the growth of human cancer cell lines A-549 (lung carcinoma), Panc-1 (pancreatic carcinoma), and A-431 (skin epidermoid carcinoma) were evaluated, and the SAR has been clarified through analysis. With IC₅₀ values in the single-digit micromolar range, compounds 8b, 8d, 10a-b, and 10d were shown to be the most effective antiproliferative candidates against the studied cancer cell lines. They also exerted negligible cytotoxicity (with selectivity scores between 8.63 and 30.02) against the human lung MRC5 cell line. Additionally, we investigated the potential inhibitory action of compounds 8b, 8d, 10a-b, and 10d on EGFR and VEGFR-2. 10a was this investigation's most effective EGFR inhibitor, with an IC₅₀ value of 0.54 μM. Ultimately, the molecular docking analysis of congener 10a highlighted its effective suppression of EGFR by examining its binding mode and docking score compared to Erlotinib. These findings underscore the potential of spirooxindole-pyrazolo[3,4-b]pyridine derivatives as promising anticancer agents targeting EGFR kinase.

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