Tremor occurs in up to 55% of dystonia patients, which is known as dystonic tremor syndrome (DTS). Tremor can be present in the body part affected by dystonia (dystonic tremor, DT), or an unaffected body part (tremor associated with dystonia, TAWD). DTS can be treated with botulinum neurotoxin (BoNT) injections, but BoNT is effective in only about 60-70% of patients. It is unknown which patients benefit most from BoNT treatment. We aim to explore the associations between clinical and pathophysiological tremor characteristics and BoNT efficacy. To do so, we will measure clinical, electrophysiological, ultrasonographic and (functional) magnetic resonance imaging ((f)MRI) characteristics before the start of BoNT treatment and measure BoNT efficacy after three three-monthly BoNT sessions.

开始日期2024-07-01

申办/合作机构

Radboud University Medical Center

[+2]

NCT05477459 / Not yet recruiting临床2期IIT

Efficacy and Safety of Minidosing Lysergic Acid Diethylamide (LSD) for Chronic Cluster Headache: a Randomized Placebo-controlled Study

This study aims to investigate the efficacy and safety of LSD 25μg every 3 days for 3 weeks versus placebo in the treatment of chronic cluster headache (cCH).
It is a 3-week double-blind placebo-controlled intervention study, preceded by a 4-week baseline observation period and followed by a 5-week post-treatment observation period.
Primary objective: to evaluate the efficacy of LSD 25μg every 3 days for 3 weeks in cCH.
Additional objectives:
To evaluate the safety of LSD 25μg every 3 days for 3 weeks in cCH.
To explore the exposure-response relationship of 25μg LSD in cCH.
To assess the effect of treatment with 25μg LSD on hypothalamic functional connectivity in patients with cCH, using resting state functional magnetic resonance imaging (rsMRI).
To explore cost-effectiveness of treatment with LSD in cCH.
To evaluate the efficacy of LSD on health-related quality of life.

开始日期2024-01-01

申办/合作机构

Radboud University Medical Center

[+3]

NCT05675007 / CompletedN/A

The Effects of a Colon-delivered Multivitamin Supplement on Brain Functioning and Its Relation With Immunometabolic and Intestinal Markers in Ageing: the COMBI Study

COMBI is a multi-center, randomized controlled trial among 70 older adults at risk of cognitive decline. The main goal is to investigate the effect of a 6-week colon-delivered multivitamin supplementation on the gut-brain axis in older adults, by assessing changes in brain function as well as intestinal changes compared to placebo.

开始日期2022-12-05

申办/合作机构

F.C. Donders Centre for Cognitive Neuroimaging

[+1]

100 项与 F.C. Donders Centre for Cognitive Neuroimaging 相关的临床结果

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0 项与 F.C. Donders Centre for Cognitive Neuroimaging 相关的专利（医药）

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183

项与 F.C. Donders Centre for Cognitive Neuroimaging 相关的文献（医药）

2015-05-01·The American Journal of Geriatric Psychiatry2区 · 医学

White Matter Integrity and Depressive Symptoms in Cerebral Small Vessel Disease: The RUN DMC Study

2区 · 医学

Article

作者: Anil M. Tuladhar ; Frank-Erik de Leeuw ; Ewoud J. van Dijk ; Karlijn F. de Laat ; Ingeborg W.M. van Uden ; Indira Tendolkar ; David G. Norris ; Anouk G.W. van Norden

OBJECTIVEDepressive symptoms are common in elderly with cerebral small vessel disease (SVD). As not every individual with SVD experiences depressive symptoms, other factors might play a role. We therefore investigated the white matter (WM) integrity of the white matter tracts in elderly with depressive symptoms, independent of global cognitive function, by applying the tract-based spatial statistics (TBSS).DESIGNProspective cohort study with cross-sectional baseline data.SETTINGRadboud University Nijmegen Medical Centre, The Netherlands.PARTICIPANTS438 individuals aged between 50-85 years, with SVD without dementia.MEASUREMENTSDiffusion tensor imaging parameters and depressive symptoms, assessed with the Center for Epidemiologic Studies Depression Scale.RESULTSCompared with non-depressed participants (N = 287), those with depressive symptoms (N = 151) had lower fractional anisotropy in the genu and body of the corpus callosum, bilateral inferior fronto-occipital fasciculus, uncinate fasciculus, and corona radiata. These differences disappeared after adjustment for white matter hyperintensities (WMH) and lacunar infarcts. Mean-, axial- and radial diffusivity were higher in these areas in participants with depressive symptoms. After additional adjustment for WMH and lacunar infarcts, the changes observed in radial diffusivity also disappeared. Adding global cognition as confounding variable altered the diffusion parameters only slightly.CONCLUSIONThis study indicates that elderly with depressive symptoms show a lower WM integrity, independent of global cognitive function, and that the presence of SVD is mostly responsible, affecting the fronto-subcortical regions and hereby disrupting the neural circuitry involved in mood regulation.

2012-01-01·Experimental Semiotics

Exploring the cognitive infrastructure of communication

作者: Peter Hagoort ; Stephen C. Levinson ; Roger Newman-Norlund ; Sarah Newman-Norlund ; Jan Peter De Ruiter ; Matthijs L. Noordzij ; Ivan Toni

Human communication is often thought about in terms of transmitted messages in a conventional code like a language. But communication requires a specialized interactive intelligence. Senders have to be able to perform recipient design, while receivers need to be able to do intention recognition, knowing that recipient design has taken place. To study this interactive intelligence in the lab, we developed a new task that taps directly into the underlying abilities to communicate in the absence of a conventional code. We show that subjects are remarkably successful communicators under these conditions, especially when senders get feedback from receivers. Signaling is accomplished by the manner in which an instrumental action is performed, such that instrumentally dysfunctional components of an action are used to convey communicative intentions. The findings have important implications for the nature of the human communicative infrastructure, and the task opens up a line of experimentation on human communication.

2011-01-01·Cortex2区 · 心理学

Spatial coding and invariance in object-selective cortex

2区 · 心理学

Article

作者: Hubert Fonteijn ; Thomas Carlson ; Frans A.J. Verstraten ; Hinze Hogendoorn

The present study examined the coding of spatial position in object selective cortex. Using functional magnetic resonance imaging (fMRI) and pattern classification analysis, we find that three areas in object selective cortex, the lateral occipital cortex area (LO), the fusiform face area (FFA), and the parahippocampal place area (PPA), robustly code the spatial position of objects. The analysis further revealed several anisotropies (e.g., horizontal/vertical asymmetry) in the representation of visual space in these areas. Finally, we show that the representation of information in these areas permits object category information to be extracted across varying locations in the visual field; a finding that suggests a potential neural solution to accomplishing translation invariance.

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100 项与 F.C. Donders Centre for Cognitive Neuroimaging 相关的转化医学

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