â??PRESCRIPTION PATTERNS AND DRUG USE IN THE OPHTHALMOLOGY OUTPATIENT DEPARTMENT IN A TERTIARY CARE TEACHING HOSPITAL OF GUJARAT: A PROSPECTIVE OBSERVATIONAL STUDYâ??

开始日期2021-10-09

申办/合作机构

Sumandeep Vidyapeeth University

CTRI/2021/04/032785 / CompletedN/AIIT

Effect of Physical Exercise on Fitness and Quality of Life in Adults with Epilepsy

开始日期2021-04-15

申办/合作机构

Sumandeep Vidyapeeth University

100 项与 Sumandeep Vidyapeeth University 相关的临床结果

登录后查看更多信息

0 项与 Sumandeep Vidyapeeth University 相关的专利（医药）

登录后查看更多信息

112

项与 Sumandeep Vidyapeeth University 相关的文献（医药）

2024-04-01·Journal of Datta Meghe Institute of Medical Sciences University

Comparative Evaluation of Cephalometric Parameters in Different Kinds of Vertical and Different Kinds of Horizontal Facial Patterns – A Cephalometric Study

作者: Goje, Santosh Kumar ; Basu, Sanjana

AbstractIntroduction:An individual can have a vertical, horizontal, or an average growth pattern, usually associated with an increased, decreased, or normal lower anterior facial height (LAFH), respectively. Irrespective of the growth pattern determined cephalometrically, the individual might have acceptable facial proportions. The treatment plan varies for such individuals.Materials and Methods:One hundred cephalograms with normal/increased and decreased clinical LAFH were included in this study. The sample was divided into four groups; 1A and 1B; 2A and 2B. Cephalometric parameters were compared among the vertical growers with increased and normal LAFH (1A and 1B); and horizontal growers with decreased and normal LAFH (2A and 2B) using an unpaired t-test.Results:Statistically significant differences were found between the two variants of vertical and horizontal growers. Cephalometrically hyperdivergent individuals (Group A) showed two variants; clinically normal and increased LAFH. Similarly, hypodivergent group (Group B) had both variants.Conclusions:The cephalometric parameters alone might not always be indicative of the true growth pattern of the individual. The clinical LAFH is a better parameter to determine the facial pattern and must be considered during orthodontic treatment planning.

2023-12-01·European Journal of Pharmaceutics and Biopharmaceutics

Oral self-nanoemulsifying drug delivery systems for enhancing bioavailability and anticancer potential of fosfestrol: In vitro and in vivo characterization

Article

作者: Sabei, Fahad Y ; Bhagwat, Durgacharan A ; Salawi, Ahmad ; Alsalhi, Abdullah ; Galatage, Sunil T ; Manjappa, Arehalli S ; Trivedi, Rahul

PURPOSEThe objective of the current research work was to fabricate a fosfestrol (FST)-loaded self-nanoemulsifying drug delivery system (SNEDDS) to escalate the oral solubility and bioavailability and thereby the effectiveness of FST against prostate cancer.METHODS3² full factorial design was employed, and the effect of lipid and surfactant mixtures on percentage transmittance, time required for self-emulsification, and drug release were studied. The optimized solid FST-loaded SNEDDS (FSTNE) was characterized for in vitro anticancer activity and Caco-2 cell permeability, and in vivo pharmacokinetic parameters.RESULTSUsing different ratios of surfactant and co-surfactant (Km) a pseudo ternary phase diagram was constructed. Thirteen liquid nano emulsion formulations (LNE-1 to LNE-13) were formulated at Km = 3:1. LNE-9 exhibited a higher % transmittance (99.25 ± 1.82 %) and a lower self-emulsification time (24 ± 0.32 s). No incompatibility was observed in FT-IR analysis. Within 20 min the solidified FST loaded LNE-9 (FSTNE) formulation showed almost complete drug release (98.20 ± 1.30 %) when compared to marketed formulation (40.36 ± 2.8 %), and pure FST (32 ± 3.3 %) in 0.1 N HCl. In pH 6.8 phosphate buffer, the release profiles are found moderately higher than in 0.1 N HCl. FSTNE significantly (P < 0.001) inhibited the PC-3 prostate cell proliferation and also caused apoptosis (P < 0.001) compared to FST. The in vitro Caco-2 cell permeability study results revealed 4.68-fold higher cell permeability of FSTNE than FST. Remarkably, 4.5-fold rise in bioavailability was observed after oral administration of FSTNE than plain FST.CONCLUSIONSFSTNE remarkably enhanced the in vitro anticancer activity and Caco-2 cell permeability, and in vivo bioavailability of FST. Thus, FST-SNEDDS could be utilized as a potential carrier for effective oral treatment of prostate cancer.

2023-10-01·Journal of Datta Meghe Institute of Medical Sciences University

Comparative Evaluation of Skeletal and Dental Effects of Mini-Implant Assisted and Corticopuncture-Facilitated Rapid Palatal Expansion in Adults: A Randomized Clinical Study

作者: Goje, Santosh Kumar ; Basu, Sanjana

AbstractIntroduction:Conventional rapid maxillary expansion (RME) in adults is difficult due to increased skeletal maturity of the midpalatal suture. Surgically assisted rapid palatal expansion (SARPE) treatment is recommended for adults with strongly consolidated sutures but has lesser acceptance due to its invasive nature. Mini-implant-assisted rapid palatal expansion (MARPE) produced dentoalveolar side effects along with some skeletal effects in adults while being highly successful in adolescents and young adults. A lesser invasive technique combined with a purely bone-borne-rapid-maxillary-expansion appliance (BBRME) is suggested in this study to achieve maximum skeletal effects and minimize the dentoalveolar side effects of expansion in adults with completely fused midpalatal sutures as an alternative to SARPE.Aim:This study aims to evaluate and compare skeletal and dental effects of mini-implant assisted, and corticopuncture-facilitated rapid palatal expansion in adults.Material and Methods:A randomized clinical study was performed on 18 patients (mean age 20.77 years) who were randomly divided into two groups: Group A (Corticopuncture-facilitated BBRME) and Group B (conventional MARPE). Pretreatment (T0) and postexpansion (T1) skeletal and dental effects of both the groups were analyzed using cone-beam computed tomography imaging.Results:A student’s paired t-test was used to evaluate the difference in expansion achieved between the two groups (T1-T0). Group A (BBRME with corticopunctures) showed increased transverse widths at the basal bone, nasal base, and jugal processes. Group B (conventional MARPE) showed increased inclination of the posterior teeth indicating dental tipping. Both groups were successfully treated with their respective protocols but dentoalveolar side effects were significantly less in group A (BBRME) suggesting a better prognosis in BBRME group.Conclusions:Greater skeletal changes were seen in group A (BBRME) (P < 0.05*) than in group B. Group B (MARPE) showed more dental side effects like dental tipping and lesser skeletal expansion. Corticopuncture-facilitated bone-borne RME (BBRME) is a viable and efficient method of maximizing skeletal expansion in adults with fully obliterated midpalatal sutures.

100 项与 Sumandeep Vidyapeeth University 相关的药物交易

登录后查看更多信息

100 项与 Sumandeep Vidyapeeth University 相关的转化医学

登录后查看更多信息