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最高研发阶段临床2期 |
首次获批国家/地区- |
首次获批日期- |
Predictors of Acute Exacerbation in Patients With COPD - an Observational Study (PACE Trial)
Chronic obstructive pulmonary disease (COPD) is a lung disease characterized by respiratory problems and poor airflow with dyspnea and cough being the main symptoms. Acute exacerbations of COPD (AECOPD) are the most important events for patients with COPD that have a negative impact on patients´ quality of life, accelerate disease progression, and can result in hospital admissions and death. It is of major clinical importance to determine predictors of an AECOPD and to identify patients who are at high risk for developing an acute exacerbation and/or to detect the beginning of or prevent an ongoing acute exacerbation as early as possible. Until now, research in the field of AECOPD has gathered and analyzed data only after manifestation of AECOPD until recovery and most of them used a retrospective study design. Therefore, the aim of this prospective trial is to collect clinical data in patients prior to the first visible clinical signs of an AECOPD to investigate potential early predictors of an AECOPD.
100 项与 Fraunhofer Item, Biomedical Research In Endstage And Obstructive Lung Disease Hannover (Breath), German Center For Lung Research (Hannover, Germany) 相关的临床结果
0 项与 Fraunhofer Item, Biomedical Research In Endstage And Obstructive Lung Disease Hannover (Breath), German Center For Lung Research (Hannover, Germany) 相关的专利（医药）
As the team reports in the Investigative Radiology journal, this method shows promise in detecting diseases such as pulmonary emphysema at an earlier stage, than it is currently available. Conventional radiographic procedures generate images based on the absorption of X-rays as they pass through the tissue. The newly developed technique of X-ray dark-field radiography uses new technology to monitor wave changes during tissue transmission to create higher resolution images.
Detailed Images With the aid of this new technique, the team from the HMGU, KUM and TUM around Dr. Ali Önder Yildirim and Prof. Oliver Eickelberg of the Comprehensive Pneumology Center (CPC), which is one of the centers of the German Center for Lung Research (DZL), achieved detailed images of soft tissue.
The study was conducted in cooperation with the Cluster of Excellence Munich-Centre for Advanced Photonics (MAP). The scientists used a small-animal scanner developed by Prof. Franz Pfeifer at the TUM to test X-ray dark-field radiography on a living organism. For their investigations, they evaluated and compared images of the lung. “With X-ray dark-field radiography, structural changes in the lung tissue are visible at an early stage”, Dr. Yildirim from the CPC/HMGU says.
Early Detection of Lung Disease “Early detection of changes in the lung tissue will improve the diagnosis of lung diseases”, explains Dr. Felix Meinel from the Institute of Clinical Radiology at the KUM. The clinical application, in particular the diagnosis of lung diseases such as pulmonary emphysema or pulmonary fibrosis, will now be tested in further studies.
Lung diseases are among the leading causes of death worldwide. Genetics, lifestyle and environmental factors all play a role in their development. The work of the Helmholtz Zentrum München, the German Research Center for Environmental Health, focuses on the major common diseases with the aim of developing new approaches to their diagnosis, treatment and prevention.
100 项与 Fraunhofer Item, Biomedical Research In Endstage And Obstructive Lung Disease Hannover (Breath), German Center For Lung Research (Hannover, Germany) 相关的药物交易
100 项与 Fraunhofer Item, Biomedical Research In Endstage And Obstructive Lung Disease Hannover (Breath), German Center For Lung Research (Hannover, Germany) 相关的转化医学
