Geneoscopy, Inc.

ST. LOUIS--( BUSINESS WIRE )-- Geneoscopy, Inc ., a life sciences company focused on developing diagnostic tests for the advancement of gastrointestinal health, announced that Erica Barnell, MD, PhD, Geneoscopy’s Chief Medical & Science Officer, will present at two important healthcare conferences, showcasing advancements in colorectal cancer (CRC) screening and early detection. Ca mbridge He althtech Institute’s Early Cancer Surveillance Dx Roundtable Breakout Discussions Topic: “Blood-based Colorectal Cancer Screening Tests – Ready for Prime-Time as a First Line Screening Test?” Date & Time: Aug. 21, 2024, at 9:30 a.m. EDT About: The presentation will shed light on the latest data and perspectives on blood-based CRC screening tests and examine recent clinical trial results. The discussion will review the benefits of blood tests, including higher patient compliance and broader demographic reach, while also addressing the challenges posed by lower sensitivity in detecting stage 1 cancer and pre-cancers compared to standard tests like colonoscopy and at-home, stool-based screening tests. American Co llege of Gastroenterology Virtual Grand Rounds Topic: “What the Practicing GI Clinician Needs to Know About Stool-Based Testing” Date & Time: Aug. 22, 2024, at 12:00 p.m. and 8:00 p.m. EDT (a pre-recorded session will also be available on ACG Education Universe on Aug. 30, 2024) About: In this discussion, Dr. Barnell and Dr. Thomas F. Imperiale, Indiana University School of Medicine and the Regenstrief Institute, will delve into the significance of stool-based testing, covering its use and implications, and role for practicing gastroenterologists. The session will explore the comparative advantages of stool-based tests over blood tests and colonoscopies, examine how sensitivity and specificity rates affect test selection, and discuss key factors influencing the recommendation of stool-based testing to patients. “I am honored to participate in these important discussions alongside leading researchers to help advance the field of gastroenterology and early CRC detection,” Dr. Barnell said. “By exploring the latest in stool-based and blood-based testing, we are paving the way for more accurate, accessible, and patient-friendly screening methods. Our goal is to ensure that patients benefit from these innovations, leading to earlier cancer detection, better treatment outcomes, and ultimately, improved survival rates.” More than 44 million Americans at average risk for CRC remain unscreened despite screening’s vital role in early detection and prevention. Access to reliable options for screening enhances the ability to detect disease early and provides valuable information to guide personalized treatment options. Geneoscopy’s FDA-approved noninvasive CRC screening test, ColoSense™, is the first to use an RNA-based assay, offering a dynamic view of disease activity. About Geneoscopy, Inc. Geneoscopy Inc. is a life sciences company focused on developing diagnostic tests for gastrointestinal health. Leveraging its proprietary, patented stool-derived eukaryotic RNA (seRNA) biomarker platform, Geneoscopy’s mission is to empower patients and providers to transform gastrointestinal health through innovative diagnostics. The company’s FDA-approved ColoSense™ test uses a proprietary RNA-based platform to screen for colorectal cancer and advanced adenomas for average-risk individuals over the age of 45. In partnership with leading universities and biopharmaceutical companies, Geneoscopy is also developing diagnostic tests for treatment selection and therapy monitoring in other GI disease areas. For more information, visit www.geneoscopy.com and follow the company on LinkedIn .

ST. LOUIS--( BUSINESS WIRE )-- Geneoscopy, Inc ., a life sciences company focused on developing diagnostic tests for the advancement of gastrointestinal health, today announced that Chief Executive Officer and Co-founder Andrew Barnell, MBA, will attend the following investor conferences: Canaccord Genuity 44th Annual Growth Conference in Boston Fireside chat on Tuesday, August 13, at 2:00 p.m. ET Morgan Stanley 22nd Annual Global Healthcare Conference in New York City Presentation on Thursday, September 5, at 3:20 p.m. ET Bank of America Healthcare Trailblazers Private Company Conference in Boston on Thursday, September 26 “It’s an honor to present the promising market opportunity of Geneoscopy’s proprietary RNA-based platform,” said Andrew Barnell, CEO and Co-founder of Geneoscopy. “We are proud of our technology’s ability to provide a reliable, scalable, and cost-effective evaluation of RNA biomarkers from stool samples, delivering the ideal platform for developing diagnostic tests to evaluate and improve gastrointestinal health.” Geneoscopy recently received FDA approval for ColoSense™, a noninvasive colorectal cancer (CRC) screening test. Despite the critical importance of early detection and prevention, more than 44 million average-risk Americans remain unscreened. ColoSense stands out as the only CRC screening test that utilizes RNA biomarkers, which are not subject to age-related patterns that can lead to variability in test performance across different age groups – a challenge for methylation-based assays. 1,2 Additionally, Geneoscopy is expanding the use of its proprietary RNA technology to develop diagnostic tests for treatment selection and therapy monitoring for patients with inflammatory bowel disease (IBD). Collaborating with leading pharmaceutical companies and academic institutions, Geneoscopy is striving to deliver promising tools for healthcare providers to aid in predicting and monitoring therapeutic effectiveness for the approximately 3 million Americans who live with IBD. About Geneoscopy, Inc. Geneoscopy Inc. is a life sciences company focused on developing diagnostic tests for gastrointestinal health. Leveraging its proprietary, patented stool-derived eukaryotic RNA (seRNA) biomarker platform, Geneoscopy’s mission is to empower patients and providers to transform gastrointestinal health through innovative diagnostics. The company’s FDA-approved ColoSense™ test uses a proprietary RNA-based platform to screen for colorectal cancer and advanced adenomas for average-risk individuals over the age of 45. In partnership with leading universities and biopharmaceutical companies, Geneoscopy is also developing diagnostic tests for treatment selection and therapy monitoring in other GI disease areas. For more information, visit www.geneoscopy.com and follow the company on LinkedIn . References: Ahlquist DA, Taylor WR, Yab TC, et al. Abstract 3572: Methylated gene marker levels in stool: Effects of demographic, drug, and body mass and other patient characteristics. Cancer Research . 2012;72(8_Supplement):3572-3572. https://doi.org/10.1158/1538-7445.am2012-3572 Ahlquist DA, Taylor WR, Yab TC, Devens ME, Mahoney DW, et al. Aberrantly methylated gene marker levels in stool: effects of demographic, exposure, body mass, and other patient characteristics. J Mol Biomark Diagn. 2012;3:133. doi:10.4172/2155-9929.1000133

ST. LOUIS--( BUSINESS WIRE )-- Geneoscopy, Inc ., a life sciences company focused on developing diagnostic tests for the advancement of gastrointestinal health, announced the publication of a peer-reviewed study in Gastro Hep Advances , highlighting the effectiveness of Geneoscopy’s noninvasive, stool-based RNA technology platform in managing Crohn’s disease (CD). The data demonstrates the feasibility to leverage stool-based RNA biomarkers to improve disease monitoring within inflammatory bowel disease (IBD). The study, titled " Noninvasive stool RNA test approximates disease activity in patients with Crohn’s disease ," assessed 102 stool samples from 68 individuals, collected over multiple time points before and after the initiation of advanced therapy. The test demonstrated 83% sensitivity and 80% specificity in distinguishing between active disease and remission. Additionally, a secondary classifier successfully differentiated between mild and moderate disease severity among those with active disease, achieving 89% sensitivity and 95% specificity. “Patients with Crohn’s disease are plagued by unpredictable periods of remission and relapse, necessitating frequent monitoring to assess disease activity and response to therapy,” said Erica Barnell, Chief Medical & Science Officer at Geneoscopy. “Using RNA biomarkers in stool samples to approximate disease activity in CD offers a noninvasive and patient-friendly approach that mitigates the need for physician appointments and uncomfortable procedures like repeated endoscopies. This study demonstrates that Geneoscopy’s technology has the potential to change how we manage and treat CD, enhancing patient outcomes and quality of life.” CD affects more than 1 million individuals in the U.S., 1 often leading to serious complications and requiring surgery for up to 80% of patients. 2 Maintaining long-term remission is crucial to effectively avoid complications, surgery, malignancy, and other side effects. 3-5 Despite advancements in treatment options, accurately evaluating disease severity and predicting therapeutic outcomes remain challenging. Geneoscopy’s platform has the potential to deliver more accurate tracking of disease progression, and provide a cost-effective, convenient way to monitor the disease, reducing healthcare expenses and overall burden. About Geneoscopy, Inc. Geneoscopy Inc. is a life sciences company focused on developing diagnostic tests for gastrointestinal health. Leveraging its proprietary, patented stool-derived eukaryotic RNA (seRNA) biomarker platform, Geneoscopy’s mission is to empower patients and providers to transform gastrointestinal health through innovative diagnostics. The company’s FDA-approved ColoSense™ test uses a proprietary RNA-based platform to screen for colorectal cancer and advanced adenomas for average-risk individuals over the age of 45. In partnership with leading universities and biopharmaceutical companies, Geneoscopy is also developing diagnostic tests for treatment selection and therapy monitoring in other GI disease areas. For more information, visit www.geneoscopy.com and follow the company on LinkedIn . References: Lewis JD, Parlet LE, Funk MLJ, et al. Incidence, Prevalence, and Racial and Ethnic Distribution of Inflammatory Bowel Disease in the United States. Gastroenterol . 2023;165:1197-1205.e2. Cosnes J, Gower-Rousseau C, Seksik P, Cortot A. Epidemiology and natural history of inflammatory bowel diseases. Gastroenterol . 2011;140(6):1785-1794. Ashton JJ, Green Z, Kolimarala V, Beattie RM. Inflammatory bowel disease: long-term therapeutic challenges. Expert Rev Gastroenterol Hepatol . 2019;13(11):1049-1063. Gupta N, Bostrom AG, Kirschner BS, et al. Incidence of stricturing and penetrating complications of Crohn’s disease diagnosed in pediatric patients. Inflamm Bowel Dis . 2010;16(4):638-644. Dubinsky MC, Lin YC, Dutridge D, et al. Serum immune responses predict rapid disease progression among children with Crohn’s disease: immune responses predict disease progression. Am J Gastroenterol . 2006;101(2):360-367.