Article
作者: Arvieux, Cédric ; Maincent, Gilles ; Tamalet, Catherine ; Sanchez, Ventzislava Petrov ; Poizot-Martin, Isabelle ; Clifford, Gary ; Hoyeau, Nadia ; Henno, Sébastien ; Combes, Jean-Damien ; Laude, Hélène ; Falguières, Michael ; Ferry, Tristan ; Del Grande, Jean ; Etienney, Isabelle ; Marchand, Lucie ; Reynes, Jacques ; Le Breton, Frédérique ; Hoyau, Nadia ; Zaegel-Faucher, Olivia ; Tattevin, Pierre ; Pirel, Marion ; Landon, Marine ; Pialoux, Gilles ; Lesage, Anne-Carole ; Canestri, Ana ; Fischer, Hugues ; Andrianiaina, Haingo Njatonirina ; Flejou, Jean-Francois ; Piroth, Lionel ; Darragh, Teresa M ; Radenne, Sylvie ; Didelot, Jean-Michel ; Clifford, Gary M ; Siproudhis, Laurent ; Costes-Martineau, Valérie ; Alberts, Catharina J ; Ressiot, Emmanuelle ; Lion, Annie ; Heard, Isabelle ; Patey, Olivier
Abstract:We assessed cumulative detection and determinants of anal high-grade squamous intraepithelial lesions (HSILs) in men who have sex with men living with human immunodeficiency virus and who underwent 3 visits over 2 years, with cytology and high-resolution anoscopy, within the ANRS-EP57-APACHES study. The cumulative HSIL detection rate was 33% (134 of 410), of which 48% HSILs were detected at baseline. HSIL detection varied considerably by center (from 13% to 51%). The strongest HSIL determinants were baseline human papillomavirus 16 (adjusted odds ratio, 8.2; 95% confidence interval, 3.6–18.9) and p16/Ki67 (4.6 [2.3–9.1]). Repeated annual cytology and high-resolution anoscopy improved HSIL detection but did not fully compensate for between-center heterogeneity.