更新于：2024-11-01

the Germans Trias i Pujol Research Institute (IGTP)

更新于：2024-11-01

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项与 the Germans Trias i Pujol Research Institute (IGTP) 相关的临床试验

NCT05780073 / Recruiting临床2期IIT

Safety and Impact of Dasatinib on Viral Persistence and Inflammation in People With HIV Under Antiretroviral Treatment

The goal of this clinical trial is to evaluate the safety, tolerability and Impact of low dose Dasatinib in People with Human Immunodeficiency Virus (PWH) on suppressive Combined Antiretroviral Therapy (cART),.
The main question it aims to answer are:
How safe and tolerable is Dasatinib administered at low dose
To evaluate the on-target/biological effect of Dasatinib in "in vitro" T-cells activation and its durability after completion of the treatment
To evaluate the effect of Dasatinib on inflammation and immune activation, on the HIV-1 reservoir, and on cluster of differentiation 4 (CD4) and cluster of differentiation 8 (CD8) cell counts.
To characterize Dasatinib concentrations in plasma and its relationships with the observed effects.
Participants will be treated with Dasatinib or matched Placebo once a day for 24 weeks. Suppressive cART will remain unchanged during the entire study. Participants will be followed until week 48, in a total of eleven visits.

开始日期2023-10-16

申办/合作机构

the Germans Trias i Pujol Research Institute (IGTP)

[+3]

EUCTR2022-002688-31-ES / Unknown status临床4期IIT

LEVO-MEMS: COMPARISION OF THE HAEMODINAMIC PROFILE OF DOBUTAMIN AND LEVOSIMENDAN IN THE CURRENT THERAPEUTICAL CONTEXT

开始日期2023-01-25

申办/合作机构

the Germans Trias i Pujol Research Institute (IGTP)

100 项与 the Germans Trias i Pujol Research Institute (IGTP) 相关的临床结果

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0 项与 the Germans Trias i Pujol Research Institute (IGTP) 相关的专利（医药）

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220

项与 the Germans Trias i Pujol Research Institute (IGTP) 相关的文献（医药）

2024-09-17·Environmental Science & Technology

Socioeconomic Inequalities in the External Exposome in European Cohorts: The EXPANSE Project

Article

作者: Dadvand, Payam ; Nobile, Federica ; Ibi, Dorina ; Blay, Natalia ; de Hoogh, Kees ; de Cid, Rafael ; Åström, Christofer ; Vlaanderen, Jelle ; Melén, Erik ; Koppelman, Gerard ; Coloma, Fabián ; Yu, Zhebin ; Saucy, Apolline ; Tonne, Cathryn ; Olmos, Sergio ; Huss, Anke ; de Bont, Jeroen ; Samoli, Evangelia ; Vermeulen, Roel ; Gehring, Ulrike ; Stafoggia, Massimo ; Wolf, Kathrin ; Boer, Jolanda M.A. ; Ljungman, Petter ; Vienneau, Danielle ; Nieuwenhuijsen, Mark ; Peters, Annette ; Dimakopoulou, Konstantina ; Katsouyanni, Klea ; Pickford, Regina

Socioeconomic inequalities in the exposome have been found to be complex and highly context-specific, but studies have not been conducted in large population-wide cohorts from multiple countries. This study aims to examine the external exposome, encompassing individual and environmental factors influencing health over the life course, and to perform dimension reduction to derive interpretable characterization of the external exposome for multicountry epidemiological studies. Analyzing data from over 25 million individuals across seven European countries including 12 administrative and traditional cohorts, we utilized domain-specific principal component analysis (PCA) to define the external exposome, focusing on air pollution, the built environment, and air temperature. We conducted linear regression to estimate the association between individual- and area-level socioeconomic position and each domain of the external exposome. Consistent exposure patterns were observed within countries, indicating the representativeness of traditional cohorts for air pollution and the built environment. However, cohorts with limited geographical coverage and Southern European countries displayed lower temperature variability, especially in the cold season, compared to Northern European countries and cohorts including a wide range of urban and rural areas. The individual- and area-level socioeconomic determinants (i.e., education, income, and unemployment rate) of the urban exposome exhibited significant variability across the European region, with area-level indicators showing stronger associations than individual variables. While the PCA approach facilitated common interpretations of the external exposome for air pollution and the built environment, it was less effective for air temperature. The diverse socioeconomic determinants suggest regional variations in environmental health inequities, emphasizing the need for targeted interventions across European countries.

2024-09-01·AIDS and Behavior

Determinants of Repeating an HIV Test Among Gay, Bisexual, and Other Men Who have Sex with Men, and Transgender People Who Use an Online-Requested Self-Sampling Program and Attending Community-Based Testing Venues in Spain (2018–2021)

Article

作者: Rius Gibert, Cristina ; Agustí, Cristina ; Fernàndez-López, Laura ; Alonso, Lucia ; Aceiton Cardona, Jordi ; Alarcón Gutiérrez, Miguel ; Martínez-Riveros, Héctor ; Montoro-Fernández, Marcos ; Casabona, Jordi ; Díaz, Yesika

Our aims were: (1) to characterize gay, bisexual and other men who have sex with men (GBMSM) and transgender (TG) populations using internet-based self-sampling services in the TESTATE project or attending community-based STI/HIV voluntary counselling and testing (CBVCT) services as alternative strategies to formal HIV testing within the Spanish national health system, and (2) to identify factors associated with repeat use of the same screening strategy from November 2018 to December 2021. Demographic, health, and behavioral characteristics of users using complementary strategies were analyzed. We developed a cross-sectional study, with descriptive analysis, HIV cascade, and a multivariate logistic model to identify factors associated with participants' repeated use of the same screening strategy. We included 9939 users, of whom 94.1% were GBMSM (n = 9348) and 5.9% TG (n = 580), with a high representation of migrants. Reactive results were 3.4% (n = 340), with 3.0% in GBMSM (n = 277/9348) and 10.7% in TG (n = 63/591). 73.8% (n = 251) were confirmed HIV positive and 76.7% (n = 194) were linked to health services. Users repeated the online screening strategy more than CBVCT (44.3% vs. 31.8%), but TG population used face-to-face community services more (8.4% vs. 0.6%). Factors influencing the repetition of the online self-sampling strategy included older age, non-migrant status, and recent HIV testing. In the CBVCT strategy, factors included older age, TG identity, non-migrant status, condom use during the last sexual encounter, and recent HIV testing. In conclusion, both CBVCT and online-requested self-sampling at home are important alternatives to the health system for the provision of HIV testing to GBMSM and TG.

2024-08-16·The Journal of Infectious Diseases

Analysis of a Large Severe Acute Respiratory Syndrome Coronavirus 2 (Alpha) Outbreak in a Catalan Prison Using Conventional and Genomic Epidemiology

Article

作者: Márquez, P ; Soler, L ; Moruno, M A ; Martínez, D ; Varoucha, A C ; Noguera-Julian, Marc ; Fontan, J ; Prat, E ; Riquelme, M ; Sánchez, A ; Cruz, E ; Blanco, Ignacio ; Caraballo, V ; Sánchez, M ; Moreno, E A ; Casañ, C ; Panisello Yagüe, D ; Gómez, S ; Guerrero-Murillo, M ; Aranda, A ; Alvo, J ; Puig, P ; Fernández-Náger, Juan ; Armenteros, B ; Santalucía, J ; Giménez, M ; Egido, R M ; Guillament, M ; Azqueta, J ; Clarà, G ; Fernández-Recio, Juan ; Martin, A ; Parra, N ; Infante, J A ; Martínez, J ; Conill, V ; Rastrollo, L ; Díaz, M R ; González, V ; Encarnación, R ; Moreno, M ; Puertolas, A ; Cardona, P J ; Rodríguez, F J ; Sánchez-Roig, Montserrat ; Porras, M ; Huguet, S ; Verú, M ; Sala, I ; Muñoz, I ; Galvany, R ; Alonso, T ; Chouldry, G ; Vallès, Xavier ; Bordoy, Antoni E ; Garcia, M ; Ramos, M ; Puig, A ; Gallego, C ; Marco, Andrés ; Pedrerol, M ; Saludes, Verónica ; Pale, A M ; Jiménez, A G ; Fuentes, M ; Escamilla, M ; Arguelles, M J ; Latorre, C ; Martró, Elisa ; Balcázar, E P ; Garcia, B ; González, M

AbstractEnforcing strict protocols that prevent transmission of airborne infections in prisons is challenging. We examine a large severe acute respiratory syndrome coronavirus 2 outbreak in a Catalan penitentiary center in February–April 2021, prior to vaccination deployment. The aim was to describe the evolution of the outbreak using classical and genomic epidemiology and the containment strategy applied. The outbreak was initially detected in 1 module but spread to 4, infecting 7 staff members and 140 incarcerated individuals, 6 of whom were hospitalized (4.4%). Genomic analysis confirmed a single origin (B.1.1.7). Contact tracing identified transmission vectors between modules and prevented further viral spread. In future similar scenarios, the control strategy described here may help limit transmission of airborne infections in correctional settings.

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100 项与 the Germans Trias i Pujol Research Institute (IGTP) 相关的转化医学

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