Delving into the Latest Updates on 上海阳帆医药科技有限公司 with Synapse

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关联

2

项与上海阳帆医药科技有限公司相关的药物

YF-245-13

靶点

DPP-4

作用机制

DPP-4抑制剂

在研机构-

原研机构

上海阳帆医药科技有限公司

在研适应症-

非在研适应症

2型糖尿病

最高研发阶段无进展

首次获批国家/地区-

首次获批日期-

YF-62-80

靶点

SGLT2

作用机制

SGLT2抑制剂

在研机构-

原研机构

上海阳帆医药科技有限公司

在研适应症-

非在研适应症

糖尿病

最高研发阶段无进展

首次获批国家/地区-

首次获批日期-

1

项与上海阳帆医药科技有限公司相关的临床试验

CTR20192047

/ Active, not recruiting临床1期

YF-49-92.MLS在中国健康受试者中单次给药耐受性、药代动力学特征及初步剂量探索的单中心I期临床研究

主要目的：评价中国健康受试者空腹单次口服YF-49-92.MLS的安全性及耐受性。次要目的：评价中国健康受试者空腹单次口服YF-49-92.MLS的药代动力学特征。评价食物对中国健康受试者单次口服YF-49-92.MLS的药代动力学和安全性的影响。

开始日期2019-10-16

申办/合作机构

南京长澳医药科技有限公司

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100 项与上海阳帆医药科技有限公司相关的临床结果

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0 项与上海阳帆医药科技有限公司相关的专利（医药）

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3

项与上海阳帆医药科技有限公司相关的文献（医药）

Zhongguo Yiyao Gongye Zazhi

Synthesis of ethyl 2-[6,7-dihydro-1H-indeno[5,4-b]furan-8(2H)-ylidene]acetate

作者: Chen, Yilang ; Gao, Fei ; Chen, Youxi

1-(2-Bromoethoxy)-3-iodobenzene (4) was prepared from 3-iodophenol and 1,2-dibromoethane.And Et 5-bromo-2-pen enoate (7) was prepared from propylene glycol by reduction with MnO₂, Witting reaction with Et (triphenylphosphoranylidene) acetate and bromonation.Et 2-[6,7-dihydro-1H-indeno[5,4-b]furan-8(2H)-ylidene]acetate, the intermediate of ramelteon, was synthesized from 4 and 7 in the presence of palladium acetate/triphenylphosphine/norbornene with an overall yield of about 51%.

Guangzhou Huagong

Preparation method of (1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine

作者: Wang, Wei ; Wang, Bin-bin

The preparation and optimization of (1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine were studied.(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine was prepared from 3,4-difluoro-bromobenzene via eight steps including Friedel-crafts acylation, stereoselective reduction, cyclization, cyclopropanation, hydrolysis, debromination, amidation and Hoffman elimination.Not only the raw materials and reagents used in the improved process can be found easily in industry, but also the expenses were much lower.It can be found much easier when operating the reaction and purifying and storing the intermediates of each step.The stereo selectivity was higher with fewer wastes, and it was more environmentally friendly.The improved process is more suitable for scale-up of industrial production

Guangzhou Huagong

The synthesis of phenyl-2-amino pyridine derivatives

作者: Zhao, Chuan-sheng

A new route of phenyl-2-amino pyridine derivatives was presented.The desired compound was synthesized through 6 steps which used 1,2,4-trichlorobenzene as starting material and was characterized by ¹H NMR spectra and Ms.Those steps involved Wittig reaction, Staudinger reaction, aza-Wittig reaction, electrocyclic ring-closure of intramol. and 1,3-proton shift, etc.A reasonable reaction mechanism was proposed.The method provided a new way of phenyl-2-amino pyridine derivatives which ware was very difficult to synthesize by coupling.

100 项与上海阳帆医药科技有限公司相关的药物交易

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100 项与上海阳帆医药科技有限公司相关的转化医学

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