Multicenter cohort research evaluating the effectiveness and safety of SGLT-2 inhibitor and DPP-4 inhibitor and metformin combined therapy in type 2 diabetes mellitus based on real-world study

开始日期2024-09-30

申办/合作机构

广州汇民中西医结合医院

ChiCTR2400080630 / SuspendedN/A

The mechanism and clinical empirical study of the regulation of ITA-GATA3 signaling pathway by auricular vagus nerve stimulation in the treatment of chronic insomnia comorbidities dyspepsia in the elderly

开始日期2024-06-01

申办/合作机构

广州汇民中西医结合医院

ChiCTR-IPC-16007832 / Suspended

The Integrated Mechanism of Emotional Center of Treating Perimenopausal Insomnia from Liver by Acupuncture

开始日期2016-02-01

申办/合作机构

广州汇民中西医结合医院

100 项与广州汇民中西医结合医院相关的临床结果

登录后查看更多信息

0 项与广州汇民中西医结合医院相关的专利（医药）

登录后查看更多信息

项与广州汇民中西医结合医院相关的文献（医药）

2019-01-01·Caries Research2区 · 医学

A Membrane-Targeted Peptide Inhibiting PtxA of Phosphotransferase System Blocks Streptococcus mutans

2区 · 医学

Article

作者: Xiang, Shao-Wen ; He, Jian ; Shao, Jun ; Zhao, Wang-Hong ; Wu, Xin-Yu ; Xu, Xiao-Hu

Streptococcus mutans, the primary cause of dental caries, takes up carbohydrates through the phosphoenolpyruvate sugar phosphotransferase system (PTS). This study aimed to identify a novel membrane-targeted antimicrobial peptide (AMP) that could also target the L-ascorbate-specific PtxA component of the S. mutans PTS system. C10-KKWW was identified and selected using virtual screening of a lipopeptide library, a minimum inhibiting concentration (MIC) assay, cytotoxicity assays and a hemolysis assay. Surface plasmon resonance confirmed that C10-KKWW had a high binding affinity for PtxA. Combining with scanning electron microscopy and cell permeability assay, it was shown that the effects of C10-KKWW could be attributed to both membrane and PtxA. Wild type (WT) S. mutans, a ptxA deletion mutant (ΔptxA), and a mutant-complemented strain (CptxA), were cultured consistently in brain heart infusion (BHI) medium, tryptone-vitamin medium supplemented with 15 mM L-ascorbate (TVL), or for 5 h in BHI supplemented with 7.4 mM sodium L-ascorbate. Compared to ∆ptxA, in WT S. mutans and CptxA, C10-KKWW had a stronger MIC (3.9 μg/mL), and distinctively decreased biofilm viability. The extracellular concentrations of L-ascorbate/sodium L-ascorbate were not changed before and after WT treated with C10-KKWW. L-ascorbate-induced operon genes, or other PTS genes, were significantly suppressed by C10-KKWW. In conclusion, C10-KKWW has been developed; it acts through interaction with the bacterial membrane and interferes with L-ascorbate translocation to inhibit S. mutans growth and eradicate its biofilm. C10-KKWW may be especially effective at optimal oral ascorbate levels. A combination of C10-KKWW with sodium L-ascorbate might also be a novel strategy for dental caries treatment.

International Journal of Environmental Research and Public Health

Field Measurements and Analysis of Indoor Environment, Occupant Satisfaction, and Sick Building Syndrome in University Buildings in Hot Summer and Cold Winter Regions in China

Article

作者: Zhu, Wei ; Sun, Yukai ; Chen, Zefeng ; Zhang, Yuhan ; Weng, Jiantao ; Ying, Xiaoyu

Teachers and students work and study in classrooms for long durations. The indoor environment directly affects the health and satisfaction of teachers and students. To explore the performance differences between green buildings, conventional buildings, and retrofitted buildings in terms of their indoor environment, occupant satisfaction, and sick building syndrome (SBS), as well as the correlation between these different aspects, three university teaching buildings were selected in hot summer and cold winter regions in China. These included a green building (GB), a retrofitted building (RB), and a conventional building (CB). Long-term indoor environment monitoring and point-to-point measurements were conducted during the transition season and winter and the indoor environment, satisfaction, and SBS in the three buildings were compared. A sample of 399 point-to-point questionnaires was collected. A subjective-objective indoor environmental quality (IEQ) evaluation model for schools in China was established, covering satisfaction and the indoor environment. The results showed that the compliance rate of the indoor environment in the GB and RB was generally superior to that of the CB. The overall satisfaction was the highest for the GB, followed by the CB, and then the RB. The GB had the highest overall indoor environment quality score, followed by the RB and then the CB. The occurrence of SBS was lowest in the CB, followed by the GB, and then the RB. It was determined that the design of natural ventilation should be improved and that building users should be given the right to autonomous window control and temperature control. To reduce the occurrence of SBS symptoms, attention should be paid to the control of temperature and CO2 concentration. To improve learning efficiency, it suggests reducing indoor CO2 concentrations and improving desktop illuminance. This study provides a reference for improving the indoor environment and health performance of existing university teaching buildings.

Xin Zhongyi

Clinical observation on Jianpibushen decoction combined with western medicine in treatment of osteoporosis

作者: Zhou, Ye ; Qiu, Xiaoming ; Liang, Haiping

Objective: To observe the clin. effect of Jianpibushen decoction combined with western medicine on osteoporosis.Methods: 180 Patients with osteoporosis were divided into 2 groups, each with 90 cases.The control group was treated with alendronate sodium phosphate and salmon calcitonin injection.The study group was treated with Jianpibushen decoction on the basis of the control group.The clin. efficacy and related indicators of the two groups were observedResults: The total effective rate was 94.4% in the study group and 81.1% in the control group, with statistically significant difference between the two groups (P < 0.01).After treatment, the pain scores of both groups decreased (P < 0.05), with a statistically significant difference in the pain scores of the two groups (P < 0.05).After treatment, the differences in ALP, U-Ca/Cr, and U-Hop/Cr of the two groups were statistically significant compared with those before treatment (P < 0.05).After treatment, the differences in ALP, U-Ca/Cr, and U-Hop/Cr were not statistically significant between the two groups (P > 0.05).Conclusion: The self-made Jianpibushen decoction combined with western medicine can significantly improve the clin. symptoms and bone metabolism of patients, which is safe and effective.

100 项与广州汇民中西医结合医院相关的药物交易

登录后查看更多信息

100 项与广州汇民中西医结合医院相关的转化医学

登录后查看更多信息