How perinatal factors affect the long-term development of children has always been an issue of much concern. This study is designed to explore the potential impact of maternal neuraxial labor analgesia exposure on offspring neurodevelopment.

开始日期2022-10-14

申办/合作机构

北京大学第一医院

[+2]

NCT04948424

/ CompletedN/AIIT

A Retrospective Observational Study to Describe Anaemia Management, Burden of Disease and Outcomes in Chinese Patients on Peritoneal Dialysis Using a Clinical Database

The overall objective is to describe the epidemiology, health care resource utilisation (HCRU) and selected clinical outcomes in patients initiating PD by anaemia status in real-world setting in China.

开始日期2022-01-01

申办/合作机构

北京大学第一医院

[+16]

NCT03571451

/ RecruitingN/AIIT

A Multi-center Prospective Cohort Study Based on Peritoneal Dialysis Telemedicine-assisted Platform

Increasing the proportion of patients on peritoneal dialysis (PD) may relieve the financial burden caused by the growing number of patients with end-stage renal disease (ESRD). The investigators are developing a PD database in China using peritoneal dialysis telemedicine-assisted platform (PD TAP). The survival rate and technique survival rate of PD patients, as well as risk factors associated with survival and technique survival will be analyzed through PD TAP.

开始日期2016-06-01

申办/合作机构

北京大学第一医院

[+17]

100 项与太原市中心医院相关的临床结果

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0 项与太原市中心医院相关的专利（医药）

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268

项与太原市中心医院相关的文献（医药）

2025-04-01·Clinical Nutrition ESPEN

Associations of dietary factors with amyotrophic lateral sclerosis: A Mendelian randomization study

Article

作者: Xu, Fei ; Yin, Zhaoxu ; Xing, Xiaolian ; Liu, Hongwei ; Chen, Xuan

BACKGROUNDAn inconsistent yet notable relationship between dietary habits and the risk of amyotrophic lateral sclerosis (ALS) has been previously established, with the causative nature of this relationship remaining uncertain. This study aims to explore the causal connections at a genetic level.METHODSA two-sample Mendelian Randomization (MR) based analysis was conducted utilizing a comprehensive, publicly assessable Genome-wide association study (GWAS) database. Fourteen dietary variables were examined as potential exposure factors, and the ALS outcome data was statistically analyzed. The inverse-variance weighted (IVW) approach was used as the primary analytical method, supplemented by sensitivity analyses to assess the reliability of our findings.RESULTSOur analysis identified significant protective effects against ALS from increased intake of water (fixed-effects IVW: OR = 0.700, 95 % CI: 0.524-0.935, P = 0.016), fresh fruit (random-effects IVW: OR = 0.561, 95 % CI: 0.361-0.871, P = 0.010), and cooked vegetable (fixed-effects IVW: OR = 0.200, 95 % CI: 0.090-0.445, P = 0.000). No significant associations were found for the other 11 dietary factors examined.CONCLUSIONThe study highlights the protective association of cooked vegetables and fresh fruit intake with ALS risk reduction. Additionally, an intriguing association between water intake and ALS was observed, warranting further investigation to elucidate the underlying mechanisms.

2025-04-01·International Journal of Biological Macromolecules

Biomass spinach-drived metal-free carbon dots-based nanozyme for multimodal nitrite sensing and functionalized by glucose oxidase as ROS amplifiers to enhance tumor therapy

Article

作者: Zhang, Dongmei ; Yan, Wenjun ; Li, Yingqi ; Dong, Xiaorui ; Dong, Xiuqing

The metal-free carbon dots (CDs) nanozyme, which is endowed generation of multiple reactive oxygen species (ROS), followed by highly selective chemical sensing, remains a critical challenge. The exceptional biocatalytic properties of glucose oxidase (GOx) have spurred the development of GOx-functionalized nanocatalysts for cancer therapy. Here, the innovative free metal-doped CDs and CDs@GOx nanozymes with peroxidase (POD)-like activity were developed, which specifically catalyzed H₂O₂ to engender multiple ROS including •O₂^-, ¹O₂ and •OH, to oxidize colorless 3,3',5,5'-tetramethylbenzidine (TMB) to blue ox-TMB, indicating both nanozymes can be as ROS amplifiers to enhance tumor therapy. The introduction of NO₂^- triggered a distinct color change from blue to green ascribed to the diazotization of ox-TMB along with quenching the fluorescence of CDs, which endowed high selectivity and sensitivity for NO₂^- detection. Furthermore, CDs catalyzed endogenous H₂O₂ within tumor cells, to effectively destroy cancer cells rather than normal cells. As expected, CDs@GOx preferentially catalyze glucose in cancer cells to further supply H₂O₂, allowing more ROS accumulation, thereby realizing the integration of starvation therapy and ROS therapy of cancer. Notably, in vivo anti-tumor efficacy demonstrated that CDs and CDs@GOx markedly inhibited tumor growth without external stimulation with neglected side effects. Compared to the saline group, the tumor size was reduced by 3 or 4 times for CDs and CDs@GOx, respectively. This metal-free CDs tailors a convenient and impactful nanoplatform for chemical sensing and as ROS amplifiers to enhance tumor therapy by non-invasive treatment.

2025-02-21·ACS Applied Nano Materials

Cu²⁺-Mediated Cascade-Responsive Nanodiamond-Based Platform Triggering Redox Dyshomeostasis for Cancer-Specific Chemo/Chemodynamic Combination Therapy

作者: Zhang, Dongmei ; Qiao, Hui ; Yan, Wenjun ; Li, Yingqi ; Zhang, Wenxia ; Li, Jianguo

The redox homeostasis in tumor cells is an innate defense barrier for reactive oxygen species (ROS)-mediated tumor therapy.Herein, an intratumoral cascade-responsive multifunctional nanodiamond-based platform (NPCD) with a hydrodynamic diameter of 191 ± 5 nm triggering redox dyshomeostasis is fabricated by Cu2+-mediated coordination for polylysinated nanodiamond and doxorubicin (DOX) to achieve cancer-specific diagnosis and therapy.The NPCD nanoplatform enables precise tumor fluorescence localization and chemotherapy through a "turn on" effect due to being specifically activated by GSH to trigger DOX release at a low-pH tumor-specific environment instead of normal cells.Furthermore, NPCD realizes Cu+-based chemodynamic therapy (CDT) and induces GSH depletion by Cu2+ reduction to support CDT.These cause intracellular redox dyshomeostasis, making tumor cells more sensitive to the NPCD nanoparticles.Addnl., NPCD also possesses the intrinsic ability to reverse drug resistance.Of note, NPCD mainly accumulates in the tumor site in 4T1 tumor-bearing mice and enhances the efficacy of therapeutic interventions with negligible side effects.More interestingly, combined with programmed cell death ligand 1 antibody (anti-PD-L1) and imiquimod (R837), NPCD significantly suppresses distant tumor growth, indicating a good immune response.Therefore, this work opens perspectives for the further development of synergistic therapy through a Cu2+-mediated intratumoral cascade reaction.

项与太原市中心医院相关的新闻（医药）

2024-04-23

·BioBAY

企业资讯丨荣登国际医学顶刊！中国原创SMART研究成果即将重磅发表

近日，基于BioBAY园内企业信迈医疗自主研发的msRDN系统、由中国专家原创的肾神经标测/选择性肾动脉消融（msRDN：Mapping/Selective Renal Denervation）治疗高血压SMART试验6个月随访结果即将重磅发表于国际权威顶尖医学期刊柳叶刀《The Lancet》旗下子刊《eClinicalMedicine》。本次国际医学顶级期刊发表来自于中国的原创试验数据，不仅仅是国际学术界给予该项研究成果的高度认可，更标志着我国学者在RDN领域的原创科研能力走在国际前沿。《eClinicalMedicine》是《The Lancet》旗下的高端学术期刊，在全球169个综合内科医学类期刊中排名第14，影响因子为15.1。在经同行五位评审专家多轮严苛审评后，《eClinicalMedicine》正式接受并将刊出SMART试验的6个月随访数据，题为“Efficacy and Safety of Sympathetic Mapping and Ablation of Renal Nerves for the Treatment of Hypertension (SMART): 6-Month Follow-Up of A Randomised, Controlled Trial”。这不仅彰显了国际专家对SMART试验结果的科学严谨性的高度认可，也是承认了msRDN和SMART试验以诊室血压达标率和抗高血压药物负荷为复合终点来评价RDN治疗高血压患者获益的全球创新性。这标志着msRDN与rfRDN、uRDN在RDN领域三足鼎立，完整建立了msRDN从基础研究到临床前试验、临床试验方法学、直至临床方案全证据链的经典构架，确立了中国学者在这领域中的学术和临床实践领先地位。SMART基于信迈医疗自主研发的msRDN系统，在中国心血管界领军人物霍勇教授、葛均波院士、孙宁玲教授的带领下，是我国RDN领域第一个前瞻性、多中心、随机、单盲、假手术对照（RCT）的原创研究，该试验完全由中国医生在中国本土完成，是RDN领域中第一个在顶级期刊所发表的、来自于中国的RCT试验结果。这一实验结果表明，运用msRDN可靶向性的去除肾交感神经，在手术中术者可即时判断是否去除了肾交感神经，在每侧肾动脉主干施行4个位点的消融，即可在显著降低抗高血压药物负荷的情况下，将患者诊室收缩压控制达标（<140 mmHg）。这一结果具有重大的临床意义，首次应用血压达标和抗高血压药物负荷的变化来评价RDN治疗高血压的有效性，是全球首创且唯一的应用肾神经标测/选择性消融技术展开的RCT研究。msRDN手术可降低患者抗高血压药物负荷具有重大的临床意义，因为随着患者抗高血压药物负荷的减低，其服药依从性会显著提高，进而提高患者的血压控制达标率，最终改善高血压患者的临床结局。因此，msRDN试验数据的发布，是中国学界和业界首次在RDN治疗高血压领域中，以RCT结果的方式发出了中国声音，展示了我国学者在RDN领域中临床研究的新方法和成功例证。以SMART研究结果登顶柳叶刀子刊为新的起点，为全球RDN治疗高血压的临床试验和临床实践都树立了一个新的标杆。这一文章的共同作者或参与SMART试验的学者们有：北京大学第一医院霍勇教授、马为教授和郑博教授，复旦大学附属中山医院葛均波院士、胡嘉禄教授和姚志峰教授，北京大学人民医院孙宁玲教授、王伟民教授和刘健教授，重庆医科大学附属第二医院殷跃辉教授、陈伟杰教授和肖培林教授，天津市第一中心医院卢成志教授、何强教授和王丽教授，武汉大学人民医院江洪教授、崔博教授和谢菁教授，武汉大学中南医院鲁志兵教授，江苏省人民医院陈明龙教授、王捷教授、陈红武教授、褚明教授、王悦、刘海雷教授和蔡铖教授，河北省人民医院齐晓勇教授和党懿教授，南京市第一医院陈绍良教授和朱建成教授，白求恩国际和平医院王冬梅教授和丁超教授，太原市中心医院王彦斌教授，大庆油田总医院黎辉教授和潘震华教授，四川大学华西医院崔凯军教授，徐州医科大学附属医院王志荣教授和李承宗教授，深圳市人民医院董少红教授和梁新剑教授，苏州信迈医疗科技股份有限公司张晶晶。SMART试验数据统计分析工作由北京大学医学部的姚晨教授团队承担，由阎小妍教授领衔负责实施，其专业素养、严谨态度为研究提供了强有力的支持。泰格医药作为本试验的CRO,以丰富经验和专业能力，进一步保障了试验的质量。国家药品监督管理局在2015年首次和2019年再次批准msRDN系统进入创新医疗器械特别审批程序，并对SMART试验的全过程给予了指导。SMART试验结果6个月数据将于近日在《eClinicalMedicine》上全文发表。▌文章来源：信迈医疗责编：赵家帅审核：任旭推荐阅读企业资讯丨尧健生物：SPF级动物试验设施正式启动，为个性化医疗策略注入创“心”动能企业资讯丨玄刃科技：与金域医学合作研发全自动液基细胞学制片工作站三代，助力女性健康企业资讯丨齐禾生科与凯盛浩丰签订战略合作协议

临床研究临床终止

100 项与太原市中心医院相关的药物交易

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100 项与太原市中心医院相关的转化医学

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