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新冠多表位疫苗(Fuyang Normal University/City University of Hong Kong)

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香港城市大学 [+1]

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香港城市大学 [+1]

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新型冠状病毒感染

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100 项与阜阳师范大学相关的临床结果

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0 项与阜阳师范大学相关的专利（医药）

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2,674

项与阜阳师范大学相关的文献（医药）

2025-09-01·Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

Ratiometric fluorescent probe for triphosgene detection and its application in electrospun fluorescent fibers

Article

作者: Qiao, Rui ; Wei, Biao ; Wang, Shizhen ; Xue, Wenhui ; Song, Qixiang ; Miao, Hui ; Wang, Xinyu ; Wang, Xin ; Zhang, Lin ; Chen, Mengyu ; Liu, Chenxu ; Bai, Cuibing

Triphosgene poses a potentially great threat to human health and safety. Therefore, it is of great significance to develop an effective method to realize the inexpensive, on-site, convenient, and rapid detection of triphosgene. Herein, based on the excited-state intramolecular proton transfer mechanism, a new fluorescent probe DPIM was designed and synthesized, which realized the rapid ratiometric identification and detection of triphosgene for the first time. Its limit of detection for triphosgene was 3.54 × 10^-8 M, and it had a large Stokes shift of 198 nm. Its recognition mechanism was comprehensively analyzed. A smartphone detection platform and probe-loaded test paper were prepared to realize the inexpensive, on-site, and convenient detection of triphosgene. DPIM effectively enabled the ratiometric fluorescence "turn-on" for detecting residual triphosgene in the sand, showing its application practicality. Most importantly, the probe was incorporated into nanofibers and successfully used to monitor gaseous triphosgene with high specificity, showing its excellent application potential. This study provides a promising analytical tool for the rapid quantitative detection of triphosgene in solution and gaseous phases.

2025-09-01·Talanta

Protein-inorganic hybrid flowers with a two-stage accelerated strategy for stimulated activation of CRISPR/Cas12a enhance polynucleotide kinase biosensing

Article

作者: Fan, Suhua ; Chen, Xiumei ; Wu, Hai ; Yang, Shuo ; Wang, Qi ; Xia, Juan ; Li, Yang

Polynucleotide kinases (PNK) play a crucial role in DNA damage repair and are closely associated with specific diseases, making them promising targets for therapeutic intervention. In this study, we propose a two-stage accelerated strategy that utilizes protein-inorganic hybrid flowers (PHFs) to enhance the performance of the terminal deoxynucleotidyl transferase (TdT)-combined CRISPR/Cas12a system (TCS) for efficient detection of PNK activity. In TCS, the participation of PHFs confines the substrate probes (SPs) to a limited space, thereby significantly enhancing the local concentration of phosphorylated 3' termini of SPs and effectively promoting the enzymatic reaction kinetics as the first step in the accelerated strategy. Upon encountering the target PNK, the phosphorylated 3' termini were promptly recognized and dephosphorylated to 3'-OH termini. Subsequently, TdT catalyzed the assembly of deoxyadenosine triphosphates (dATPs) without a template, rapidly activating the CRISPR/Cas12a system by forming multiple polyadenine (poly-A) chains. PHF-fixed poly-A chains then substantially boosted the localized concentration of CRISPR/Cas12a systems and vastly enhanced their efficacy in cleaving reporter nucleic acids. Our findings indicated that the spatial confinement effect facilitated by PHFs promoted frequent molecular collisions and accelerated multiple enzymatic reactions. The developed sensing strategy allows for the detection of PNK activity within a linear range of 0.001-1 U/mL, with a detection limit of 1.82 × 10^-4 U/mL. Additionally, this strategy has been successfully applied to detect PNK activity in cell extracts and to screen for PNK inhibitors. Owing to these advantages, PNK can be rapidly and accurately detected with a high sensitivity, specificity, and biostability.

2025-08-01·Journal of Molecular Structure

The adsorption and light hydrocarbon separation performance for the scalable synthesis of microporous Cu-MOF

作者: Zhang, Zi-You ; Chen, Shui-Sheng ; Du, Yu-Ting ; Xu, Yu-Han ; Zhang, Xiao-Xia ; Huo, Meng-Yu

A porous material possessing remarkable thermal and chem. stability is prepared via a rapid and easily scalable approach.The favorable stability and porosity endow the material with suitable gas adsorption and separation properties.The C₂H₂, C₂H₄, C₂H₆, CH₄ and CO₂ uptakes of [Cu(L)] are 52.05, 44.12, 31.65, 18.87, and 23.52 cm³ g^-1 at 298 K and 1 atm, while the corresponding uptake capacities increase to 62.18 61.98, 31.65, 32.35, and 37.04 cm³ g^-1 at 273 K and 1 atm.The coverage-dependent adsorption enthalpies (Q_st) for C₂H₂, C₂H₄, C₂H₆, CO₂ and CH₄ range from 31.95 to 36.36, 32.65-33.46, 9.42-28.69, 32.28-33.33, and 22.05-23.36 kJ mol^-1.The ideal adsorbed solution theory (IAST) is carried out to valuate the selectivity of binary equimolar mixtures of C₂H₂/CO₂, C₂H₂/CH₄, and CO₂/CH₄, which are 5.75, 7.28, and 1.79 at 298 K and 100 kPa, resp.Breakthrough experiments verify its availability in separating CO₂ and CH₄ from C₂H₂/CO₂ and C₂H₂/CH₄ mixtures, with CO₂ and CH₄ elution time reaching within 15 and 14 min g^-1, resp.This work seeks to enhance gas separation methodologies and elevate the purity of acetylene, a crucial industrial feedstock.

100 项与阜阳师范大学相关的药物交易

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100 项与阜阳师范大学相关的转化医学

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