更新于：2024-11-01

4-1BB x LRRC15

更新于：2024-11-01

基本信息

关联

项与 4-1BB x LRRC15 相关的药物

LRRC15 NovaTE(NovaRock Biotherapeutics)

靶点

4-1BB x LRRC15

作用机制

4-1BB抑制剂 [+1]

在研机构

Novarock Biotherapeutics Ltd.

原研机构

Novarock Biotherapeutics Ltd.

在研适应症

肉瘤 [+1]

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期1800-01-20

100 项与 4-1BB x LRRC15 相关的临床结果

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100 项与 4-1BB x LRRC15 相关的转化医学

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0 项与 4-1BB x LRRC15 相关的专利（医药）

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项与 4-1BB x LRRC15 相关的文献（医药）

2000-01-01·Bioscience, Biotechnology, and Biochemistry4区 · 工程技术

Purification, Characterization and Substrate Specificities of Xylanase Isoenzymes fromMelanocarpus albomycesIIS 68

4区 · 工程技术

Article

作者: Virendra S. Bisaria ; Vibhor Saraswat

The ascomycetous fungus Melanocarpus albomyces when grown on wheat straw produced seven extracellular xylanase isoenzymes, designated as la, Ib, Ic, IIa, lib, llc, and lId. All seven xylanases were purified to homogeneity by gel filtration and ion-exchange chromatography. The molecular mass (kDa) of la, lb, Ic, Ila, lIb, lIc, and lId were estimated to be 22.9, 20.7, 18.6, 31.3, 25.4, 38.5, and 34.3, respectively by SDS-PAGE, and 23.7, 20.5, 17.1, 31.7, 25.1, 39.8, and 32.2, respectively by gel filtration. The isoelectric points of Ia, lb, Ic, Ila and IIb were found to be 6.2, 6.3, 6.4, 3.7, and 4.4, respectively. The activity of the isoenzymes was dependent on the type of the xylan substrates; Xylanases Ia, lb, and Ic showed highest specific activity toward larchwood xylan (an arabinoglucuronoxylan), IIa and Ilc toward birchwood xylan (a glucuronoxylan), and llb and IId toward beechwood xylan (a glucuronoxylan). Four isoenzymes la, lb, Ic, and Ila had an arabinose-releasing property on larchwood xylan. Application of specific isoenzymes as prebleaching agents in paper manufacture is proposed.

1986-11-01·Journal of Experimental Biology2区 · 生物学

Localization and release of FMRFamide-like immunoreactivity in the cerebral neuroendocrine system of Manduca sexta

2区 · 生物学

Article

作者: Calabrese, R. L. ; Carrow, G. M. ; Carroll, L. S.

ABSTRACTThe distribution of FMRFamide-like immunoreactivity (FLI) in the cerebral neuroendocrine system of the moth, Manduca sexta, is described and evidence is provided for calcium-dependent release of FLI from the neurohaemal organs.FLI was detected by indirect immunofluorescence in approximately 25 bilaterally symmetrical pairs of somata in the pupal protocerebrum. In addition, FLI was observed in neurites in the brain, as well as in axons of the nervi corporis cardiaci and nervi corporis allati, and in terminals in the neurohaemal corpora cardiaca (CC) and corpora allata (CA). All immunocytochemical staining was blocked by preabsorption of the anti-FMRFamide antiserum with synthetic FMRFamide. We localized FLI to identified protocerebral neurosecretory cells (NSCs) by combining intracellular injection of Lucifer Yellow and indirect immunofluorescence. Among the NSCs in each hemisphere, FLI was observed in both group Ila (lateral) cells, in most group lib (lateral) cells, and in two cells of group lb (medial). FLI was extracted from the brain and neurohaemal organs and measured using radioimmunoassay (RIA). Calcium-dependent release of FLI was evoked from isolated CC-CA by high potassium depolarization in vitro and was quantified by RIA of the bathing medium.These results suggest that FLI may have a neurohormonal or neurotransmitter function in Manduca.