更新于：2024-11-01

PSAC

更新于：2024-11-01

基本信息

别名-

简介-

关联

项与 PSAC 相关的药物

12F

靶点

PSAC

作用机制

PSAC抑制剂

在研机构

CSIR-Indian Institute of Chemical Biology

原研机构

CSIR-Indian Institute of Chemical Biology

在研适应症

诺氏疟原虫感染

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期1800-01-20

Antiplasmodial and antileishmanial(The University of North Carolina)

靶点

PSAC

作用机制

PSAC抑制剂

在研机构

The University of North Carolina at Chapel Hill

原研机构

The University of North Carolina at Chapel Hill

在研适应症

利什曼病 [+1]

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期1800-01-20

100 项与 PSAC 相关的临床结果

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100 项与 PSAC 相关的转化医学

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0 项与 PSAC 相关的专利（医药）

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267

项与 PSAC 相关的文献（医药）

2024-10-01·The Plant Journal

Overexpression of the transcription factor ANAC017 results in a genomes uncoupled phenotype under lincomycin

Article

作者: Whelan, James ; Liew, Lim Chee ; Štaka, Zorana ; Narsai, Reena ; He, Cunman ; Bai, Chen ; Zhu, Yanqiao ; Berkowitz, Oliver

SUMMARYOver‐expression (OE) lines for the ER‐tethered NAC transcription factor ANAC017 displayed de‐repression of gun marker genes when grown on lincomycin (lin). RNA‐seq revealed that ANAC017OE2 plants constitutively expressed greater than 40% of the genes induced in wild‐type with lin treatment, including plastid encoded genes ycf1.2 and the gene cluster ndhH‐ndhA‐ndhI‐ndhG‐ndhE‐psaC‐ndhD, documented as direct RNA targets of GUN1. Genes encoding components involved in organelle translation were enriched in constitutively expressed genes in ANAC017OE2. ANAC017OE resulted in constitutive location in the nucleus and significant constitutive binding of ANAC017 was detected by ChIP‐Seq to target genes. ANAC017OE2 lines maintained the ability to green on lin, were more ABA sensitive, did not show photo‐oxidative damage after exposure of de‐etiolated seedlings to continuous light and the transcriptome response to lin were as much as 80% unique compared to gun1‐1. Both double mutants, gun1‐1:ANAC017OE and bzip60:ANAC017OE (but not single bzip60), have a gun molecular gene expression pattern and result in variegated and green plants, suggesting that ANAC017OE may act through an independent pathway compared to gun1. Over‐expression of ANAC013 or rcd1 did not produce a GUN phenotype or green plants on lin. Thus, constitutive ANAC017OE2 establishes an alternative transcriptional program that likely acts through a number of pathways, that is, maintains plastid gene expression, and induction of a variety of transcription factors involved in reactive oxygen species metabolism, priming plants for lin tolerance to give a gun phenotype.

2024-08-01·Plant Communications

GENOMES UNCOUPLED PROTEIN1 binds to plastid RNAs and promotes their maturation

Article

作者: Kleine, Tatjana ; Masuda, Tatsuru ; Doroodian, Paymon ; Brachmann, Andreas ; Xu, Duorong ; Hua, Zhihua ; Tang, Qian ; Schmitz-Linneweber, Christian ; Lenzen, Benjamin ; Yapa, Madhura M. ; Leister, Dario ; Yapa, Madhura M

Plastid biogenesis and the coordination of plastid and nuclear genome expression through anterograde and retrograde signaling are essential for plant development. GENOMES UNCOUPLED1 (GUN1) plays a central role in retrograde signaling during early plant development. The putative function of GUN1 has been extensively studied, but its molecular function remains controversial. Here, we evaluate published transcriptome data and generate our own data from gun1 mutants grown under signaling-relevant conditions to show that editing and splicing are not relevant for GUN1-dependent retrograde signaling. Our study of the plastid (post)transcriptome of gun1 seedlings with white and pale cotyledons demonstrates that GUN1 deficiency significantly alters the entire plastid transcriptome. By combining this result with a pentatricopeptide repeat code-based prediction and experimental validation by RNA immunoprecipitation experiments, we identified several putative targets of GUN1, including tRNAs and RNAs derived from ycf1.2, rpoC1, and rpoC2 and the ndhH-ndhA-ndhI-ndhG-ndhE-psaC-ndhD gene cluster. The absence of plastid rRNAs and the significant reduction of almost all plastid transcripts in white gun1 mutants account for the cotyledon phenotype. Our study provides evidence for RNA binding and maturation as the long-sought molecular function of GUN1 and resolves long-standing controversies. We anticipate that our findings will serve as a basis for subsequent studies on mechanisms of plastid gene expression and will help to elucidate the function of GUN1 in retrograde signaling.

2024-06-01·Food Chemistry: X

Effects and mechanisms of proanthocyanidins-derived carbon dots on alleviating salt stress in rice by muti-omics analysis

Article

作者: Chen, Fengqiong ; Hu, Chaofan ; Liu, Yingliang ; Liu, Guo ; Lei, Bingfu ; Guo, Baoyan ; Li, Wentao ; Li, Wei ; Wang, Lashuang ; Zhang, Xuejie ; Zhuang, Jianle

Carbon dots (CDs) with different structures were prepared by electrolysis (PE-CDs) and hydrothermal (PH-CDs) methods using proanthocyanidins as precursors. The smaller size and lower zeta potential enabled the PE-CDs treated rice seedlings to exhibit greater resistance to salt stress. The fresh weight of rice seedlings under salt stress was significantly increased by spraying CDs every other day for two weeks. PE-CDs treated group exhibited a faster electron transport rate, and the SOD activity and flavonoid content were 2.5-fold and 0.23-fold higher than those of the salt stress-treated group. Furthermore, the metabolomics and transcriptomics analysis revealed that the PsaC gene of photosystem I was significantly up-regulated under PE-CDs treatment, which accelerated electron transfer in photosystem I. The up-regulation of BX1 and IGL genes encoding indole synthesis allowed rice to enhance stress tolerance through tryptophan and benzoxazine biosynthesis pathways. These findings offer help in purposefully synthesizing CDs and boosting food production.