更新于：2024-11-01

GP1BB

更新于：2024-11-01

基本信息

别名

Antigen CD42b-beta、CD42c、glycoprotein Ib (platelet), beta polypeptide

+ [7]

简介

Gp-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to von Willebrand factor, which is already bound to the subendothelium.

关联

靶点

GP1BB

作用机制

GP1BB拮抗剂

在研机构-

原研机构

Katholieke Universiteit Leuven

在研适应症-

非在研适应症

血栓栓塞

最高研发阶段无进展

首次获批国家/地区-

首次获批日期1800-01-20

100 项与 GP1BB 相关的临床结果

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100 项与 GP1BB 相关的转化医学

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0 项与 GP1BB 相关的专利（医药）

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558

项与 GP1BB 相关的文献（医药）

2024-12-31·Hematology

Bernard–Soulier syndrome caused by two novel heterozygous GP1BA gene mutations: a case report and literature review

Review

作者: Ling, Jing ; Zhang, Senlin ; Cui, Kai ; Zhan, Shihong ; Hu, Shaoyan ; Wang, Wenyi ; Fan, Junjie ; Zheng, Jiajia

BACKGROUNDBernard-Soulier syndrome (BSS) is a rare inherited macrothrombocytopenia, usually autosomal recessive, which is characterized by prolonged bleeding, thrombocytopenia, and abnormally large platelets.METHODSFor more than 6 years, we misdiagnosed a patient with BSS without an obvious bleeding tendency as having idiopathic thrombocytopenia purpura (ITP), prior to obtaining a genetic analysis. On admission, routine hematology showed a platelet count of 30 × 10⁹/L and mean platelet volume (MPV) of 14.0 fL.RESULTSWhole-exome sequencing revealed two likely pathogenic heterozygous mutations (c.95_101del and c.1012del) in GP1BA. Flow cytometry analysis of platelet membrane glycoproteins indicated that the expression of GP1b was 0.28% of the normal level. Platelet aggregation tests indicated that platelet aggregation was inhibited by ristocetin- (1.7%), ADP- (14.5%), and arachidonic acid- (5.6%) induced platelet aggregation. A literature review identified reports on 53 mutations in the GP1BA gene in 253 patients, 29 mutations in the GP1BB gene in 90 patients, and 32 mutations in the GP9 gene in 114 patients.CONCLUSIONThis case report describes two novel gene mutation sites that have not been reported previously, enriching understanding of the GP1BA mutation spectrum.

2024-10-01·Environmental Research

Alterations in the placental proteome in association with the presence of black carbon particles: a discovery study

Article

作者: Demazy, Catherine ; Martens, Dries S. ; Fransolet, Maude ; Martens, Dries S ; Nawrot, Tim S ; Luyten, Leen J ; Ameloot, Marcel ; Plusquin, Michelle ; Millen, Joline L. ; Dieu, Marc ; Renard, Patricia ; Bongaerts, Eva ; Bové, Hannelore ; Debacq-Chainiaux, Florence ; Reimann, Brigitte ; Nawrot, Tim S. ; Millen, Joline L ; Luyten, Leen J.

BACKGROUNDExposure to ambient air pollution is known to cause direct and indirect molecular expression changes in the placenta, on the DNA, mRNA, and protein levels. Ambient black carbon (BC) particles can be found in the human placenta already very early in gestation. However, the effect of in utero BC exposure on the entire placental proteome has never been studied to date.OBJECTIVESWe explored whether placental proteome differs between mothers exposed to either high or low BC levels throughout the entire pregnancy.METHODSWe used placental tissue samples from the ENVIRONAGE birth cohort, of 20 non-smoking, maternal- and neonate characteristic-matched women exposed to high (n=10) or low (n=10) levels of ambient BC throughout pregnancy. We modeled prenatal BC exposure levels based on the mother's home address and measured BC levels in the fetal side of the placenta. The placental proteome was analyzed by nano-liquid chromatography Q-TOF mass spectrometry. PEAKS software was used for protein identification and label-free quantification. Protein-protein interaction and functional pathway enrichment analyses were performed with the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) software.RESULTSThe accumulation of BC particles in placenta was 2.19 times higher in the high versus low exposure group (20943.4 vs 9542.7 particles/mm³; p=0.007). Thirteen proteins showed a ≥ 2-fold expression difference between the two exposure groups, all overexpressed in the placentas of women prenatally exposed to high BC levels. Three protein-protein interactions were enriched within this group, namely between TIMP3 and COL4A2, SERPINE2 and COL4A2, and SERPINE2 and GP1BB. Functional pathway enrichment analysis put forward pathways involved in extracellular matrix-receptor interaction, fibrin clot formation, and sodium ion transport regulation.DISCUSSIONPrenatal BC exposure affects the placental proteome. Future research should focus on the potential consequences of these alterations on placental functioning, and health and disease during early childhood development.

2024-08-01·Journal of Chromatography A

One-step fabrication of dipeptide-based bifunctional polymer for individual enrichment of glycopeptides and phosphopeptides from serum

Article

作者: Ding, Chuan-Fan ; Meng, Luyan ; Zhang, Shun ; Cai, Ting ; Wang, Bing ; Zhang, Sijia ; Yan, Yinghua

A dipeptide-based bifunctional material immobilized with Ti⁴⁺ (denoted as APE-MBA-VPA-Ti⁴⁺) was developed using precipitation polymerization. This polymer combines hydrophilic interaction liquid chromatography (HILIC) and immobilized metal affinity chromatography (IMAC) enrichment strategies, allowing for the individual and simultaneous enrichment of glycopeptides and phosphopeptides. It demonstrated high sensitivity (0.1 fmol μL^-1 for glycopeptides, 0.005 fmol μL^-1 for phosphopeptides), strong selectivity (molar ratio HRP: BSA = 1:1000, β-casein: BSA = 1:2500), consistent reusability (10 cycles) and satisfactory recovery rate (93.5 ± 1.8 % for glycopeptides, 91.6 ± 0.6 % for phosphopeptides) in the individual enrichment. Utilizing nano LC-MS/MS technology, the serum of liver cancer patients was analyzed after enrichment individually, resulting in the successful capture of 333 glycopeptides covering 262 glycosylation sites, corresponding to 131 glycoproteins, as well as 67 phosphopeptides covering 57 phosphorylation sites, related to 48 phosphoproteins. In comparison, the serum of normal healthy individuals yielded a total of 283 glycopeptides covering 244 glycosylation sites corresponding to 126 glycoproteins, as well as 66 phosphopeptides covering 56 phosphorylation sites related to 37 phosphoproteins. Label-free quantification identified 10 differentially expressed glycoproteins and 8 differentially expressed phosphoproteins in the serum of liver cancer patients. Among them, glycoproteins (HP, BCHE, AGT, C3, and PROC) and phosphoproteins (ZYX, GOLM1, GP1BB, CLU, and TNXB) showed upregulation and displayed potential as biomarkers for liver cancer.