更新于：2024-11-01

PAOX x SMOX

更新于：2024-11-01

基本信息

关联

项与 PAOX x SMOX 相关的药物

MDL-72527

靶点

PAOX x SMOX

作用机制

PAOX inhibitors [+2]

在研机构

Veterans Administration Outpatient Clinic [+3]

原研机构

Aventis SA

在研适应症

糖尿病性视网膜病变 [+1]

非在研适应症

肿瘤

最高研发阶段临床前

首次获批国家/地区-

首次获批日期1800-01-20

100 项与 PAOX x SMOX 相关的临床结果

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100 项与 PAOX x SMOX 相关的转化医学

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0 项与 PAOX x SMOX 相关的专利（医药）

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项与 PAOX x SMOX 相关的文献（医药）

2023-09-12·Biology of Reproduction

Regulation of synthesis of polyamines by progesterone, estradiol, and their receptors in uteri of cyclic ewes

Article

作者: Sah, Nirvay ; Bazer, Fuller W ; Wu, Guoyao ; He, Wenliang ; Stenhouse, Claire ; Moses, Robyn M ; Halloran, Katherine M ; Newton, Makenzie G

AbstractProgesterone (P4), estradiol (E2), and expression of their receptors (PGR and ESR1, respectively) by cells of the uterus regulate reproductive performance of mammals through effects on secretion and transport of nutrients into the uterine lumen. This study investigated the effect of changes in P4, E2, PGR, and ESR1 on expression of enzymes for the synthesis and secretion of polyamines. Suffolk ewes (n = 13) were synchronized to estrus (Day 0) and then, on either Day 1 (early metestrus), Day 9 (early diestrus), or Day 14 (late diestrus) of the estrous cycle, maternal blood samples were collected, and ewes were euthanized before obtaining uterine samples and uterine flushings. Endometrial expression of MAT2B and SMS mRNAs increased in late diestrus (P < 0.05). Expression of ODC1 and SMOX mRNAs decreased from early metestrus to early diestrus, and expression of ASL mRNA was lower in late diestrus than in early metestrus (P < 0.05). Immunoreactive PAOX, SAT1, and SMS proteins were localized to uterine luminal, superficial glandular, and glandular epithelia, stromal cells, myometrium, and blood vessels. Concentrations of spermidine and spermine in maternal plasma decreased from early metestrus to early diestrus and decreased further in late diestrus (P < 0.05). The abundances of spermidine and spermine in uterine flushings were less in late diestrus than early metestrus (P < 0.05). These results indicate that synthesis and secretion of polyamines are affected by P4 and E2, as well as the expression of PGR and ESR1 in the endometria of cyclic ewes.

2023-05-09·Biomolecules

The Role of Spermidine and Its Key Metabolites in Important, Pathogenic Human Viruses and in Parasitic Infections Caused by Plasmodium falciparum and Trypanosoma brucei.

Review

作者: Kaiser, Annette

The triamine spermidine is a key metabolite of the polyamine pathway. It plays a crucial role in many infectious diseases caused by viral or parasitic infections. Spermidine and its metabolizing enzymes, i.e., spermidine/spermine-N¹-acetyltransferase, spermine oxidase, acetyl polyamine oxidase, and deoxyhypusine synthase, fulfill common functions during infection in parasitic protozoa and viruses which are obligate, intracellular parasites. The competition for this important polyamine between the infected host cell and the pathogen determines the severity of infection in disabling human parasites and pathogenic viruses. Here, we review the impact of spermidine and its metabolites in disease development of the most important, pathogenic human viruses such as SARS-CoV-2, HIV, Ebola, and in the human parasites Plasmodium and Trypanosomes. Moreover, state-of-the-art translational approaches to manipulate spermidine metabolism in the host and the pathogen are discussed to accelerate drug development against these threatful, infectious human diseases.

2022-07-01·Cancer Gene Therapy2区 · 医学

The biguanide polyamine analog verlindamycin promotes differentiation in neuroblastoma via induction of antizyme

2区 · 医学

Article

作者: Sbirkov, Yordan ; Barker, Karen ; Urban-Wójciuk, Zuzanna ; Kwok, Colin ; Campbell, James ; Chesler, Louis ; Poon, Evon ; Graham, Amy ; Howell, Louise ; Petrie, Kevin ; Woster, Patrick M

AbstractDeregulated polyamine biosynthesis is emerging as a common feature of neuroblastoma and drugs targeting this metabolic pathway such as DFMO are in clinical and preclinical development. The polyamine analog verlindamycin inhibits the polyamine biosynthesis pathway enzymes SMOX and PAOX, as well as the histone demethylase LSD1. Based on our previous research in acute myeloid leukemia (AML), we reasoned verlindamycin may also unblock neuroblastoma differentiation when combined with all-trans-retinoic acid (ATRA). Indeed, co-treatment with verlindamycin and ATRA strongly induced differentiation regardless of MYCN status, but in MYCN-expressing cells, protein levels were strongly diminished. This process was not transcriptionally regulated but was due to increased degradation of MYCN protein, at least in part via ubiquitin-independent, proteasome-dependent destruction. Here we report that verlindamycin effectively induces the expression of functional tumor suppressor—antizyme via ribosomal frameshifting. Consistent with previous results describing the function of antizyme, we found that verlindamycin treatment led to the selective targeting of ornithine decarboxylase (the rate-limiting enzyme for polyamine biosynthesis) as well as key oncoproteins, such as cyclin D and Aurora A kinase. Retinoid-based multimodal differentiation therapy is one of the few interventions that extends relapse-free survival in MYCN-associated high-risk neuroblastoma and these results point toward the potential use of verlindamycin in this regimen.