别名 ATR1、b(0,+)-type amino acid transport protein、CSNU1 + [8] |
简介 Associates with SLC7A9 to form a functional transporter complex that mediates the electrogenic exchange between cationic amino acids and neutral amino acids, with a stoichiometry of 1:1 (PubMed:8663357, PubMed:16825196, PubMed:32817565, PubMed:32494597, PubMed:11318953, PubMed:7686906, PubMed:8486766, PubMed:8663184). Acts as a chaperone that facilitates biogenesis and trafficking of functional SLC7A9-SLC3A1 heteromers to the plasma membrane. SLC7A9-SLC3A1 transporter has system b(0,+)-like activity with high affinity for extracellular cationic amino acids and L-cystine and lower affinity for intracellular neutral amino acids (PubMed:16825196, PubMed:32817565, PubMed:32494597, PubMed:11318953, PubMed:7686906, PubMed:8486766, PubMed:8663184). Substrate exchange is driven by high concentration of intracellular neutral amino acids and the intracellular reduction of L-cystine to L-cysteine (PubMed:11318953, PubMed:7686906, PubMed:8486766, PubMed:8663184). Required for reabsorption of L-cystine and dibasic amino acids across the brush border membrane in renal proximal tubules (PubMed:10588648, PubMed:16609684). |