更新于：2024-11-01

VDCCs x GR

更新于：2024-11-01

基本信息

关联

项与 VDCCs x GR 相关的药物

Nifedipine/Lidocaine Hydrochloride

靶点

Cav2.1 x GR x SCNA x mAChRs x β2-adrenergic receptor

作用机制

Cav2.1抑制剂 [+4]

在研机构

Seaford Pharmaceuticals, Inc.

原研机构

CHIESI Farmaceutici SpA

在研适应症

肛裂

非在研适应症-

最高研发阶段批准上市

首次获批国家/地区-

首次获批日期1800-01-20

Valproic Acid/Prednisone

丙戊酸/泼尼松

靶点

GR x VDCCs

作用机制

GR激动剂 [+2]

在研机构

Respiratorius AB

原研机构

Respiratorius AB

在研适应症

B细胞淋巴瘤

非在研适应症-

最高研发阶段临床3期

首次获批国家/地区-

首次获批日期1800-01-20

100 项与 VDCCs x GR 相关的临床结果

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100 项与 VDCCs x GR 相关的转化医学

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0 项与 VDCCs x GR 相关的专利（医药）

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项与 VDCCs x GR 相关的文献（医药）

2023-01-01·Cytokine

IL-6 evoked biochemical changes in prostate cancer cells

Article

作者: Tsui, Hoyi ; Bennett, Jesse L ; Jackson, Brittany N ; Miller, Robert J ; Martin-Caraballo, Miguel

The pro-inflammatory cytokine IL-6 has been associated with the progression of PCa to a castration-resistant phenotype. In this work, we characterized the biochemical changes evoked by IL-6 in three different models of PCa cells, including LNCaP, C4-2, and PC3. The effect of IL-6 on PCa cells was compared with the effect obtained by co-stimulation with the cAMP-inducing agent forskolin (FSK). Stimulation of LNCaP cells with IL-6 or IL-6 + FSK evoked increased expression of the neuroendocrine marker tubulin IIIβ and Cav3.2 T-type Ca²⁺ channel subunit. PC3 cells, representing a more advanced state of PCa, had high levels of tubulin IIIβ expression without any further changes observed by treatment with IL-6 or IL-6 + FSK. Elevated expression of the glucocorticoid receptor was observed in PC3, but not in LNCaP or C4-2 cells. Glucocorticoid receptor expression was not regulated by IL-6 stimulation of LNCaP or C4-2 cells. IL-6 acting alone or together with FSK evoked a significant reduction in the expression of the transcription factor REST and retinoblastoma tumor suppressor protein Rb1. In LNCaP cells, IL-6 acting alone or together with FSK had no effect on the expression of several biological markers of advanced PCa, including Aurora kinase A, valosin-containing protein, calcium-sensing receptor, calreticulin, S100A protein, and Protein S. In PC3 cells, co-treatment with IL-6 + FSK evoked increased expression of REST and S100A proteins, as well as a reduction in Protein S levels. These findings reveal a complex pattern of biochemical changes in PCa cells under the influence of IL-6.

2022-04-05·Proceedings of the National Academy of Sciences1区 · 综合性期刊

Histone methylation-mediated microRNA-32-5p down-regulation in sensory neurons regulates pain behaviors via targeting Cav3.2 channels

1区 · 综合性期刊

Article

作者: Jiang, Dongsheng ; Huang, Zitong ; Cao, Junping ; Jiang, Xing-Hong ; Sun, Yufang ; Qi, Renfei ; Zhang, Yuan ; Tao, Jin ; Snutch, Terrance P. ; Li, Yanping

Significance In this study, we identify microRNA-32-5p (miR-32-5p) as a key functional noncoding RNA in trigeminal-mediated neuropathic pain. We report that injury-induced histone methylation attenuates the binding of glucocorticoid receptor to the promoter region of the miR-32-5p gene and decreases the expression of miR-32-5p, in turn promoting the development of neuropathic pain through regulation of Cav3.2 channels. miRNA-mediated gene regulation has been proposed as a therapeutic approach in neuropathic pain. Our findings identify miR-32-5p replenishment as a therapeutic strategy for treating chronic neuropathic pain.

2021-11-01·3 Biotech4区 · 工程技术

Understanding the genomic architecture of clinical mastitis in Bos indicus

4区 · 工程技术

Article

作者: Niranjan, Saket Kumar ; Yadav, Vandana ; Raina, Varinder Singh ; Nayee, Nilesh ; Kour, Aneet ; Deb, Sitangsu Mohan

This study elucidated potential genetic variants and QTLs associated with clinical mastitis incidence traits in Bos indicus breed, Sahiwal. Estimated breeding values for the traits (calculated using Bayesian inference) were used as pseudo-phenotypes for association with genome-wide SNPs and further QTL regions underlying the traits were identified. In all, 25 SNPs were found to be associated with the traits at the genome-wide suggestive threshold (p ≤ 5 × 10^-4) and these SNPs were used to define QTL boundaries based on the linkage disequilibrium structure. A total of 16 QTLs were associated with the trait EBVs including seven each for clinical mastitis incidence (CMI) in first and second lactations and two for CMI in third lactation. Nine out of sixteen QTLs overlapped with the already reported QTLs for mastitis traits, whereas seven were adjudged as novel ones. Important candidates for clinical mastitis in the identified QTL regions included DNAJB9, ELMO1, ARHGAP26, NR3C1, CACNB2, RAB4A, GRB2, NUP85, SUMO2, RBPJ, and RAB33B genes. These findings shed light on the genetic architecture of the disease in Bos indicus, and present potential regions for fine mapping and downstream analysis in future.