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更新于：2025-05-07

CSGALNACT1

更新于：2025-05-07

基本信息

别名

Beta4GalNAcT-1、ChGn、Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 1

+ [5]

简介

Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage formation and subsequent endochondral ossification (PubMed:11788602, PubMed:12163485, PubMed:12446672, PubMed:17145758, PubMed:31705726). Moreover, is involved in the metabolism of aggrecan (By similarity).

关联

项与 CSGALNACT1 相关的药物

CN118891368

专利挖掘

靶点

CSGALNACT1

作用机制-

在研机构

Aichi Medical University

原研机构

Aichi Medical University

在研适应症

脊髓损伤

非在研适应症-

最高研发阶段药物发现

首次获批国家/地区-

首次获批日期1800-01-20

100 项与 CSGALNACT1 相关的临床结果

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100 项与 CSGALNACT1 相关的转化医学

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0 项与 CSGALNACT1 相关的专利（医药）

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项与 CSGALNACT1 相关的文献（医药）

2025-06-01·Progress in Neuro-Psychopharmacology and Biological Psychiatry

Altered volume of thalamic nuclei and genetic expression in first-episode psychotic patients, and their association with childhood adversity

Article

作者: Elvira, Uriel K A ; García-Marti, Gracian ; David-Lluesma, Javier ; Nacher, Juan ; Escarti, Maria Jose ; Molto, Maria Dolores ; Postiguillo, Alba ; Rivero, Olga ; Aguilar, Eduardo J ; Perez-Rando, Marta

Childhood maltreatment is a significant risk factor for schizophrenia, and there are correlations between these adversities and thalamic gray matter density. The thalamus, a subcortical structure with various nuclei with specific connections, relays sensory information and participates in higher cognitive processes. Thalamic alterations are evident in psychotic disorders, and early-life adversities may affect its development, potentially contributing to psychosis. However, no evidence exists of volumetric alterations in thalamic nuclei in first-episode psychosis (FEP) patients related to early traumatic events. This study recruited 70 FEP patients and 68 age-matched healthy controls, who underwent 3 T structural MRI and clinical scales, including the Childhood Trauma Questionnaire (CTQ). The thalamus was analyzed for shape and segmented into nuclei to assess volume. Additionally, peripheral blood was analyzed for the expression of VCAN, CSGALNACT1, ST8SIA4, NRGN, SP4, and TOX genes, which are related to neuronal plasticity in the thalamus and psychosis. Results showed volumetric reductions in the whole thalamus and specific nuclei (lateral posterior, lateral geniculate, medial geniculate, ventrolateral, centromedian, anteroventral, mediodorsal, and pulvinar). The thalamus did not show shape alterations. A significant association was observed between physical neglect during childhood and the volume of the left thalamus and its anteroventral nucleus. Reduced expression of ST8SIA4 and SP4 genes was detected in FEP patients compared to healthy controls, with correlations between thalamic nuclei volumes and gene expression differing between groups. In conclusion, this study links thalamic nuclei volume with childhood adversities in FEP and highlights changes in ST8SIA4 and SP4 expression, correlating with thalamic nuclei volumes.

2024-06-01·Journal of Orthopaedic Research

Cellular behavior and extracellular matrix turnover in bovine annulus fibrosus cells under hydrostatic pressure and deviatoric strain

Article

作者: Mizuno, Shuichi ; Kang, James D. ; Taiji, Ryo

AbstractIntervertebral disc herniation is a common spinal disorder that is often treated with discectomy when conservative measures fail. To devise therapeutic strategies for tears in the annulus fibrosus (AF), the regenerative capability of AF cells under spinal loading needs to be addressed. We hypothesized that the compressive loading associated with deformation in AF cells reduces synthetic and degradative activities in extracellular matrix and cell proliferation. We evaluated expression of key matrix molecules and cell proliferation by RT‐PCR and immunohistochemistry by inner and outer bovine AF cells incubated under hydrostatic pressure (HP), arc‐bending strain (Strain), and combined HP and Strain (HP/Strain) mimicking spinal loading. Inner AF cells showed significantly increased levels of aggrecan core protein, chondroitin sulfate N‐acetylgalactosaminyltransferase‐1, and tissue inhibitor of metalloproteinases‐2 by 6 days under HP (p < 0.05), with a tendency toward increased matrix metalloproteinase‐13. Outer AF cells demonstrated a significant decline in collagen type‐2 under Strain and HP/Strain (p < 0.05) and a tendency toward suppression of collagen type‐1 and elastin expression compared to HP and unloaded control. On the other hand, proliferating cell nucleus antigen increased significantly under Strain and HP/Strain in inner AF and declined under unloaded and HP in outer AF (p < 0.05). Immunohistology findings supported reductions in gene expressions of matrix molecules. Thus, changes in HP/Strain in AF appear to diminish synthetic and degradative activities while increasing cell proliferation. To promote regeneration, continuous overloading should be avoided, as it converts the synthetic activity to a state in which tissue repair is limited.

2023-03-16·The World Journal of Biological Psychiatry

DNA methylation in people with anorexia nervosa: Epigenome-wide patterns in actively ill, long-term remitted, and healthy-eater women

Article

作者: Thaler, Lea ; Steiger, Howard ; Casey, Kevin F. ; Breton, Édith ; Oliverio, Stephanie ; Booij, Linda ; Crescenzi, Olivia ; Israël, Mimi ; St-Hilaire, Annie ; Turecki, Gustavo ; Joober, Ridha ; Lee, Viveca ; Szyf, Moshe

OBJECTIVESRecent studies have reported altered methylation levels at disorder-relevant DNA sites in people who are ill with Anorexia Nervosa (AN) compared to findings in people with no eating disorder (ED) or in whom AN has remitted. The preceding implies state-related influences upon gene expression in people with AN. This study further examined this notion.METHODSWe measured genome-wide DNA methylation in 145 women with active AN, 49 showing stable one-year remission of AN, and 64 with no ED.RESULTSComparisons revealed 205 differentially methylated sites between active and no ED groups, and 162 differentially methylated sites between active and remitted groups (Q < 0.01). Probes tended to map onto genes relevant to psychiatric, metabolic and immune functions. Notably, several of the genes identified here as being differentially methylated in people with AN (e.g. SYNJ2, PRKAG2, STAT3, CSGALNACT1, NEGR1, NR1H3) have figured in previous studies on AN. Effects also associated illness chronicity and lower BMI with more pronounced DNA methylation alterations, and remission of AN with normalisation of DNA methylation.CONCLUSIONSFindings corroborate earlier results suggesting reversible DNA methylation alterations in AN, and point to particular genes at which epigenetic mechanisms may act to shape AN phenomenology.

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