更新于:2024-11-01

GPR161

基本信息

别名
G protein-coupled receptor 161、G-protein coupled receptor 161、G-protein coupled receptor RE2
+ [2]
简介
Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity).

分析

对领域进行一次全面的分析。
对领域进行一次全面的分析。
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